Evaluation of the Effect of Tobacco Use on Buccal Mucosa Graft Histology

Sterling, Joshua; Porter, Baylee A.; Zaccarini, DJ; Li, G; Bratslavksy, G; Nikolavsky, Dmitriy

doi:10.1016/j.urology.2022.03.038

Cited by 9 publications

(3 citation statements)

References 27 publications

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“…We did not find a similar relationship between tobacco use and histologic changes in BMGs. This is supported by recent literature by Policastro et al, demonstrating no clear or clinically significant histologic or immunohistochemical differences in buccal grafts harvested from smokers compared to non-smokers ( 30 ). However, both studies had relatively small sample sizes and therefore may have been underpowered to detect an association.…”

Section: Discussionsupporting

confidence: 83%

Is colorectal mucosa a reasonable graft alternative to buccal grafts for urethroplasty?: A comparison of graft histology and stretch

et al. 2023

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Section: Discussionsupporting

confidence: 83%

Is colorectal mucosa a reasonable graft alternative to buccal grafts for urethroplasty?: A comparison of graft histology and stretch

et al. 2023

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“…However, a recent study comparing the histology of buccal mucosal grafts from smokers and non-smokers found no difference in the overall architecture, vascularization, in ammatory markers, or presence of endothelial stem cells, which questions the validity of this recommendation. 13 Our results suggest, the use of BMGs may actually be favorable in smokers.…”

Section: Discussionmentioning

confidence: 61%

Smoking is not associated with wound complications in augmented urethroplasty: a NSQIP analysis

Cahill,

Islam,

Chua

et al. 2024

Int Urol Nephrol

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To investigate if predictors of wound complications differed between patients undergoing excision and primary anastomosis urethroplasty (EPA) and augmented urethroplasty. MethodsThe National Surgical Quality Improvement Program database from 2006-2018 was queried for male patients undergoing urethroplasty. Thirty-day wound complications were identi ed and categorized (super cial/deep/organ-space surgical site infections and dehiscence). Multivariable logistic regression was performed to determine risk factors associated with wound complications. Smoking history was de ned as current smoker within the past year. ResultsUrethroplasty was performed in 2251 males, with 25.46% (n = 573) using a ap or graft. There was no signi cant difference in wound complications for patients undergoing augmented urethroplasty (n = 17, 2.97%) or EPA (n = 45, 2.68%) (p = 0.9). The augmented group had a higher BMI, longer operative time, and longer length of stay. On multivariable logistic regression, risk factors associated with wound complications for patients undergoing EPA were diabetes (OR 2.56, p = 0.03) and smoking (OR 2.32, p = 0.02). However, these factors were not associated with wound complications in patients undergoing augmented urethroplasty. ConclusionsSmoking and diabetes were associated with increased wound complications for men undergoing EPA, but not in patients undergoing augmented urethroplasty. Patients with comorbidities associated with worse wound healing may be more likely to have a wound complication when undergoing EPA.

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“…In order to further assess the effect of chronic tobacco use on these pathways, recent work by Policastro et al evaluated the changes in overall histology and two key components of the wound healing capacity of buccal mucosa, p75 (NGFR) and Sox2 in buccal mucosal samples from current tobacco users, former tobacco users and patients who had never used tobacco. Strangely, there were no appreciable differences in histology ( Figures 1,2 ) or markers of regenerative capacity ( Figure 3 ) discovered between the groups ( 83 ). Together, these findings underscore the robust regenerative capacity of the epithelial stem cell niche found in the basal layer of buccal mucosa that allows it to retain its architecture in spite of routine mechanical and chemical insults—an important consideration for urologists who frequently employ it for use in various capacities as a mucosal graft.…”

Section: Overall Health Impact Of Smokingmentioning

confidence: 89%

How and why tobacco use affects reconstructive surgical practice: a contemporary narrative review

Sterling¹,

Policastro²,

Elyaguov³

et al. 2023

Transl Androl Urol

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Background and Objective: The overall negative impact of tobacco use on an individual's health has been well documented but the literature on tobacco's impact on post-surgical outcomes, specifically the outcomes after urologic surgery, is not as clear cut. The aim of this narrative review is to provide urologists with the information needed to have a nuanced pre-operative counseling conversation with patients about tobacco use. Here we combine publications on the histologic and physiologic changes induced by nicotine and tobacco use with publications from the wider surgical literature on post-operative outcomes in tobacco users.Methods: A literature search of PubMed, Google Scholar and Medline was performed using iterations of the following terms: tobacco, nicotine, changes, physiologic, histology, post-operative, and surgical.Non-English publications and abstracts were excluded. Inclusion required agreement from all authors and preference was given to human specimens over animal models for the basic science manuscripts and large database and meta-analyses over single institution experiences.

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Evaluation of the Effect of Tobacco Use on Buccal Mucosa Graft Histology

Cited by 9 publications

References 27 publications

Is colorectal mucosa a reasonable graft alternative to buccal grafts for urethroplasty?: A comparison of graft histology and stretch

Is colorectal mucosa a reasonable graft alternative to buccal grafts for urethroplasty?: A comparison of graft histology and stretch

Smoking is not associated with wound complications in augmented urethroplasty: a NSQIP analysis

How and why tobacco use affects reconstructive surgical practice: a contemporary narrative review

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