Evaluation of the Effect of Essential Hypertension on Elasticity of Ascending Aorta in Type 2 Diabetic Mellitus Patients by Echocardiography

Song, Xudong; Fan, Li; Yan, Zi-Ning; Yan, Rui

doi:10.1177/0003319720911572

Cited by 3 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 Previous studies by our group have shown that T2DM can impair ascending aorta elastic properties which may be further impaired by poor blood glucose control. 4,24 In the present study, our results showed that compared with non-T2DM controls, the thickness of EAT was significantly higher in T2DM patients, which is consistent with previous studies. 25 Colom et al 26 found that EAT was associated with subclinical atherosclerosis of coronary arteries in patients with type 1 diabetes.…”

Section: Discussionsupporting

confidence: 93%

Echocardiographic Association of Epicardial Adipose Tissue with Ascending Aorta Elasticity in Patients with Type 2 Diabetes Mellitus

et al. 2022

Self Cite

View full text Add to dashboard Cite

Epicardial adipose tissue (EAT) is an emerging cardiovascular risk factor located between the myocardium and visceral pericardium. In order to investigate the association between EAT and ascending aorta elasticity in patients with type 2 diabetes mellitus (T2DM), we prospectively enrolled a total of 135 T2DM patients and 63 age- and gender-matched non-T2DM controls in this study. They all underwent transthoracic echocardiography to measure EAT thickness and ascending aorta inner diameters which were used to calculate ascending aorta elastic parameters: compliance (C), distensibility (D), strain (S), stiffness index (SI), and Peterson’s elastic modulus (EM). We found that the values of C, D, and S were significantly lower, while SI, EM, and EAT thickness were significantly higher in T2DM patients compared with non-T2DM controls. Compared with T2DM patients with EAT < 5 mm group, C, D, and S were significantly reduced, SI and EM were significantly increased in T2DM patients with EAT ≥ 5 mm group (all P < .05). Bivariate correlation and multivariate linear regression analysis revealed that EAT was independently associated with ascending aorta elasticity. Our findings suggest that thickened EAT in patients with T2DM is associated with ascending aorta elasticity, independent of blood glucose.

show abstract

Section: Discussionsupporting

confidence: 93%

Echocardiographic Association of Epicardial Adipose Tissue with Ascending Aorta Elasticity in Patients with Type 2 Diabetes Mellitus

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…So the early evaluation of ascending aorta elasticity has important clinical significance. Impaired elasticity of the ascending aorta in diabetic patients has been confirmed [9,32]. Toutouzas et al have demonstrated that the impairment of aortic elasticity is associated with the duration of diabetes [33].…”

Section: Discussionmentioning

confidence: 98%

“…Arterial stiffness is also closely related to diabetes, especially the elasticity of ascending aorta, is an important predictor of the incidence and death of various diseases. Studies have confirmed that there is damage to LV function and ascending aorta elasticity in patients with T2DM [7][8][9]. However, there is a paucity of research in the literature regarding whether there are any differences in LV function and ascending aorta elasticity between T2DM patients with controlled and uncontrolled blood glucose.…”

Section: Introductionmentioning

confidence: 99%

Echocardiographic evaluation of the effect of poor blood glucose control on left ventricular function and ascending aorta elasticity

Song

Fan

Yan

et al. 2021

Journal of Diabetes and its Complications

Self Cite

View full text Add to dashboard Cite

Background: Type 2 diabetes mellitus (T2DM) is associated with high cardiovascular risk. Preclinical left ventricular (LV) dysfunction and subclinical arterial stiffness have been documented in patients with T2DM. The aims of this study were to investigate whether there was any differences in LV function and ascending aorta elasticity between T2DM patients with controlled [defined as glycosylated hemoglobin (HbA1c) <6.5%] and uncontrolled (HbA1c ≥6.5%) blood glucose. Methods: We studied 86 T2DM patients with preserved LV ejection fraction (LVEF) whom be divided into two groups: 42 T2DM patients with controlled blood glucose (controlled T2DM group) and 44 T2DM patients with uncontrolled blood glucose (uncontrolled T2DM group), and 40 ageand gender-matched healthy subjects as controls. They all underwent transthoracic echocardiography examination, LV systolic function was evaluated by global longitudinal strain (GLS) measured using three-dimensional speckle-tracking echocardiography. LV diastolic function was defined as the ratio of the early diastolic transmitral flow velocities (E) to average mitral annular velocity (e ̅), and E/e ̅ >14 was determined as abnormal. Ascending aorta inner diameters and brachial blood pressure were measured to calculate ascending aorta elastic parameters: compliance (C), distensibility (D), strain (S), stiffness index (SI), Peterson's elastic modulus (EM). Results: Compared to controls, patients with T2DM had reduced GLS, increased E/e ̅ and impaired ascending aorta elasticity. Furthermore, LV function and ascending aorta elasticity were more severely damaged in uncontrolled T2DM group compared with controlled T2DM group. By Pearson correlation analysis, the level of HbA1c was independently associated with the parameters of the LV function and ascending aorta elasticity. Conclusions: T2DM can impair LV myocardial function and ascending aorta elastic properties. Poor blood glucose control can lead to further damage to LV function and elasticity of the ascending aorta.

show abstract

“…In the majority of people, aortic aneurysms are incidental findings [ 51 ], which indicates the need for proper screening, as the mortality rate in acute aortic syndromes is still high [ 52 ]. In routine screening ultrasound tests, such as echocardiography, the ascending aorta is visualized [ 53 , 54 ] and its potential dilatation may be regarded as a potential indicator for further evaluation.…”

Section: Discussionmentioning

confidence: 99%

Demographical and Clinical Factors Predictive for Aortic Dilatation. When should we be Concerned about the Size?

Urbanowicz,

Rajewska-Tabor,

Olasińska-Wiśniewska

et al. 2024

Rev. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: Thoracic aortic aneurysms are often an accidental finding and result from a degenerative process. Medical therapy includes pharmacological control of arterial hypertension and smoking cessation, that slows the growth of aneurysms. An association between the dilatation of the ascending and abdominal aorta has been already reported. The aim of the study was to identify possible demographic and clinical factors that may implicate further imaging diagnostics in patients with ascending aorta dilatation. Methods: There were 181 (93 (53%) males and 88 (47%) females) patients with a median age of 54 (41–62) years who underwent cardiac magnetic resonance due to non-vascular diseases, were enrolled into retrospective analysis. Results: Multivariable analysis revealed ascending aorta dilatation (odds ratios (OR) = 7.45, 95% confidence interval (CI): 1.98–28.0, p = 0.003) and co-existence of coronary artery disease (OR = 8.68, 95% CI: 2.15–35.1, p = 0.002) as significant predictors for thoracic descending aorta dilatation. In patients with abdominal aorta dilatation, the multivariable analysis showed a predictive value of ascending aortic dilatation (OR = 14.8, 95% CI: 2.36–92.8, p = 0.004) and age (OR = 1.04, 95% CI: 1.00–1.08, p = 0.027). In addition, cut-off values were established for age groups determining the risk of thoracic aorta dilatation over 49 years and abdominal aorta dilatation over 54 years. Conclusions: The results of our analysis showed predictive factors, including ascending aorta dilatation and co-existence of coronary artery disease, particularly over 49 years of age for thoracic, while ascending aorta dilatation and age, particularly over 54 years, for abdominal aorta dilatation. These features may be considered to increase clinical vigilance in patients with aortic diameter abnormalities.

show abstract

Evaluation of the Effect of Essential Hypertension on Elasticity of Ascending Aorta in Type 2 Diabetic Mellitus Patients by Echocardiography

Cited by 3 publications

References 35 publications

Echocardiographic Association of Epicardial Adipose Tissue with Ascending Aorta Elasticity in Patients with Type 2 Diabetes Mellitus

Echocardiographic Association of Epicardial Adipose Tissue with Ascending Aorta Elasticity in Patients with Type 2 Diabetes Mellitus

Echocardiographic evaluation of the effect of poor blood glucose control on left ventricular function and ascending aorta elasticity

Demographical and Clinical Factors Predictive for Aortic Dilatation. When should we be Concerned about the Size?

Contact Info

Product

Resources

About