Evaluation of the effect of teriparatide therapy on mandibular fracture healing in rats with medication-related osteonecrosis of the jaw

Zandi, Mohammad; Dehghan, Arash; Amini, Payam; Doulati, Shideh; Rezaeian, Leila

doi:10.1007/s00784-019-02830-2

Cited by 8 publications

(4 citation statements)

References 40 publications

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“…Based on all results in the present study and the previous studies, 8,12,13 conclusions may be drawn as follows: icariin and teriparatide both have beneficial effects on bone necrosis; the benefits of icariin may relate to the promotion of soft tissue healing and enhanced expression of BMP‐2, and counteracting the inhibitory effects of bisphosphonates on angiogenesis. For teriparatide, it may be related to the promotion of RANKL and BMP‐2 expression.…”

Section: Discussionsupporting

confidence: 61%

“…The stimulative effect of icarrin on wound healing have been confirmed by other studies 13,20,21 and this may correlate to upregulated expression of VEGF which correlates to angiogenesis, 22 activated the MEK/ERK and PI3K/Akt/eNOS‐dependent signal pathways and promoted differention of keratinocyte involved in wound healing 13,20,23 . Angiogenesis is also an important factor in bone healing 12 and studies have shown the promising effect of icarrin on bone healing via promoting angiogenesis 11,24 . Besides, inflamation could delay soft tissue healing and the anti‐inflammatory effect of icarrin was also proved 25,26 .…”

Section: Discussionmentioning

confidence: 68%

“…It's reported that BPs impact the expression of genes essential for osteoblast growth 10 and icariin may resist this impaction via promotion of bone formation. Besides, icariin has shown its promotion of angiogenesis 11 which is also important in bone defect healing 12 . And pharmaceutical effects of icariin on anti‐inflammation, protecting immune system, and promoting soft tissue healing were noted 8,13 .…”

Section: Introductionmentioning

confidence: 99%

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Management of medication‐related osteonecrosis of jaw: Comparison between icariin and teriparatide in a rat model

Liu

Mattheos

Deng

et al. 2020

Journal of Periodontology

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Background The aim of this study is to compare the effects of icariin and teriparatide on the treatment of medication‐related osteonecrosis of the jaw (MRONJ) using a rat model. Methods Fifty rats undergoing ovariectomy were randomly assigned to control group (n = 10) and the MRONJ model group (n = 40). Zoledronic acid (0.2 mg/kg) and dexamethasone (2 mg/kg) were injected into rats in the model group for 8 weeks while saline was applied in control group, then all rats underwent tooth extraction and bone defect. Eight weeks later, rats diagnosed with MRONJ (n = 33) were randomly distributed to icariin (n = 11), teriparatide (n = 11), and the untreated (n = 11) group, and rats received daily 150 mg/kg icariin, 20 µg/kg teriparatide, and no intervention, respectively, for 8 weeks. Then, mandibulars were dissected for later examination. Results Rats diagnosed with MRONJ (33/40) demonstrated significantly larger area of soft tissue wound and necrotic bone with higher ratio of empty bone lacuna. Area of soft tissue wound and ratio of empty bone lacuna were significantly decreased in the icariin group compared with the untreated group, while teriparatide group revealed significantly higher ratio of receptor activator of NF‐kB ligand (RANKL)‐positive osteocytes, smaller area of necrotic bone and lower ratio of empty lacuna. The two agents were related to higher expression of BMP‐2 in osteocytes but were not statistically significant. Conclusions Icariin benefits MRONJ in terms of the area of soft tissue wound and ratio of empty lacuna. Teriparatide activates expression of RANKL and reduces the area of bone necrosis and ratio of empty lacuna in a MRONJ lesion. The data suggest possible healing improvement in patients with MRONJ and further studies to prove the efficacy of icariin.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

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Management of medication‐related osteonecrosis of jaw: Comparison between icariin and teriparatide in a rat model

Liu

Mattheos

Deng

et al. 2020

Journal of Periodontology

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“…We made a bone defect area with a width of 1 mm and a length of about 3 mm on the lower edge of the bone and took care not to damage the bone defect areas in other parts near the bone defect area. The wound area was disinfected utilizing penicillin, conventional sutures were fulfilled, and the incision was closed 10 . Three days after surgery, the model was successful if the X-ray examination showed obvious bone defect.…”

Section: Methodsmentioning

confidence: 99%

Effects of ergosteroside combined risedronate on fracture healing and BMP-2, BMP-7 and VEGF expression in rats

Hui

Liu

et al. 2021

Acta Cir. Bras.

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Purpose To evaluate the effect of ergosterol combined with risedronate on fracture healing. Methods Sixty male Sprague Dawley fracture model rats were assigned into group A (n=20), group B (n=20), and group C (n=20) at random. All rats were fed by gavage until their sacrifice as it follows: group A with ergosteroside and risedronate, group B with risedronate, and group C with saline solution. At weeks 2 and 4, 10 rats of each group were sacrificed. Healing effect and bone tissue changes in the fractures site were assessed by using hematoxylin and eosin stain histology. Enzyme-linked immunosorbent assay was used to detect the expression of serum bone morphogenetic protein-2 (BMP-2), bone morphogenetic protein-7 (BMP-7), and vascular endothelial growth factor (VEGF). Reverse transcriptase polymerase chain reaction was applied to detect the expression of osteoprotegerin (OPG) mRNA, osteocalcin (OCN) mRNA and core-binding factor subunit-?1 (CBF-?1) mRNA. Results In terms of serum BMP-2, BMP-7, and VEGF expression at weeks 2 and 4 after gavage, group A < group B < group C (P<0.05). At week 4 after gavage, serum VEGF expression in the three groups harbored positive relationship with serum BMP-2 and BMP-7 expression (P<0.05). Regarding serum OPG, OCN and CBF-?1 mRNA expression at weeks 2 and 4 after gavage, group A

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Local Single-Dose Teriparatide Administration for BRONJ Prevention: Insights from a Rat Model Study

Etemadi Sh,

Teimoori,

Sehat

et al. 2024

J. Maxillofac. Oral Surg.

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Evaluation of the effect of teriparatide therapy on mandibular fracture healing in rats with medication-related osteonecrosis of the jaw

Cited by 8 publications

References 40 publications

Management of medication‐related osteonecrosis of jaw: Comparison between icariin and teriparatide in a rat model

Management of medication‐related osteonecrosis of jaw: Comparison between icariin and teriparatide in a rat model

Effects of ergosteroside combined risedronate on fracture healing and BMP-2, BMP-7 and VEGF expression in rats

Local Single-Dose Teriparatide Administration for BRONJ Prevention: Insights from a Rat Model Study

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