Evaluation of the Effect of 4 Months of Risedronate Therapy on Femoral Strength Using Femoral Strength Analysis Tools

Takakuwa, Masayuki; Otsuka, Kenji; Konishi, Masahisa; Itabashi, Kazuo

doi:10.1177/147323000903700635

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Bir çalışmada, risedronat tedavisi uygulanan hastaların, tedavilerinin 4. ayında lomber vertebra KMY'lerinin %3, femur proksimal KMY'lerinin %3.1 arttığı saptanmıştır. [8] Başka bir çalışmada ise alendronat ve teriparatide tedavisi uygulanan hastalarda 30. ayda lomber KMY; alendronat uygulanan grupta %3-11, teriparatide uygulanan grupta ise %7-29 artış saptanmıştır. [9] Femur proksimal KMY'lerinde ise sırasıyla %0-8, %6-16 artış saptanmıştır.…”

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A comparison of the measurements with biochemical markers of bone turnover and bone mineral density in the assessment of the efficiency of osteoporosis treatment

Ataoğlu

Atik

Gül³

et al. 2013

Eklem Hastalik Cerrahisi

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Amaç: Bu çalışmada osteoporoz tedavisinin etkinliğinin değerlendirilmesinde kemik döngüsü biyokimyasal belirteçleri ve kemik mineral yoğunluğu (KMY) ölçümleri karşılaştırıldı. Hastalar ve yöntemler: Mart 2006 -Aralık 2008 tarihleri arasında kliniğimizde osteoporozlu 166 hasta çalışmaya alındı. Takiplerde ölüm ya da başka nedenlerle kontrolleri tamamlanamayan hastalar çalışmadan çıkarıldı. Daha önce herhangi bir osteoporoz tedavisi almamış olan ve çalış-mayı tamamlayan osteoporozlu 60 hastanın (49 kadın, 11 erkek; ort. yaş 65.7 yıl; dağılım 42-87 yıl) KMY ölçümleri ile çapraz bağlı N-telopeptid (NTx) değerleri kullanılarak idrarda kemik döngüsü biyokimyasal belirteçleri ölçümleri karşılaştırıldı. Bulgular: Hastaların 29'una (%48.3) cerrahi tedavi, 31'ine (%51.7) konservatif tedavi uygulandı. Hastaların ölçülen idrar NTx değerlerinde 3. ayda %38.82; 6. ayda %51.99; 12. ayda %66.41 azalma saptandı. Lomber vertebra KMY bir yıl sonunda %20.7 artarken, femur boyun KMY'de %11.9 artış saptandı. Sonuç: İdrar NTx değeri, KMY ölçümlerine kıyasla, osteoporoz tedavisine daha hızlı yanıt verdiği için, bu parametrenin tedavi etkinliğinin izleminde kullanılması uygun olabilir.Anahtar sözcükler: Kemik mineral yoğunluğu; çapraz bağlı N-telopeptid; osteoporoz; idrar. Objectives:This study aims to compare the measurements using biochemical markers of bone turnover and bone mineral density (BMD) in the assessment of the efficiency of osteoporosis treatment. Patients and methods: Between March 2006 and December 2008, 166 patients with osteoporosis in our clinic were included. Patients who were out of contact due to death or other reasons during follow-up were excluded. We compared the measurements of urinary biochemical markers of bone turnover using cross-linked N-telopeptide (Ntx) values and BMD in 60 patients (49 females, 11 males; mean age: 65.7 years; range: 42 to 87 years) with osteoporosis who were treatment-naive and completed study. Results: Twenty-nine (48.3%) of the patients received surgical treatment, while 31 (51.7%) received conservative therapy. Urine NTx values of the patients decreased 38.82% at three months; 51.99% at six months and 66.41% at 12 months. Lumbar vertebra BMD increased by 20.7% and femur neck BMD increased by 11.9% at the end of the first year. Conclusion: Urine NTx values respond to osteoporosis treatment faster than BMD measurements; thereby it may be suitable to use this parameter for the monitorization of the treatment efficiency.

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Section: Discussionunclassified

A comparison of the measurements with biochemical markers of bone turnover and bone mineral density in the assessment of the efficiency of osteoporosis treatment

Ataoğlu

Atik

Gül³

et al. 2013

Eklem Hastalik Cerrahisi

View full text Add to dashboard Cite

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Pixel-Based DXA-Derived Structural Properties Strongly Correlate with pQCT Measures at the One-Third Distal Femur Site

Baker¹,

Wagner²,

Kiratli

et al. 2017

Ann Biomed Eng

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While bone mineral density has been traditionally used to quantify fracture risk for individuals with spinal cord injuries, recent studies are including engineering measurements such as section modulus and cross sectional moment of inertia. These are almost exclusively calculated by peripheral QCT scanners which, unlike DXA scanners, are rarely found in clinical settings. Using fifty-four fresh frozen femora, we developed and validated a pixel-by-pixel method to calculate engineering properties at the distal femur using a Hologic QDR-1000 W DXA scanner and compared them against similar parameters measured using a Stratec XCT-3000 peripheral QCT scanner. We found excellent agreement between standard DXA and pixel-by-pixel measured BMD (r = 0.996). Cross-sectional moment of inertia about the anteroposterior axis measured using DXA and pQCT correlated very strongly (r = 0.99). Cross-sectional moment of inertia about the anteroposterior axis measured using DXA also correlated strongly with pQCT measured bone strength index (r = 0.99). These correlations indicate that DXA scans can measure equivalent pQCT parameters, and some existing DXA scans can be reprocessed with pixel-by-pixel techniques. Ultimately, these engineering parameters may help better quantify fracture-risk in fracture-prone populations such as those with spinal cord injuries.

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Evaluation of the Effect of 4 Months of Risedronate Therapy on Femoral Strength Using Femoral Strength Analysis Tools

Cited by 2 publications

References 15 publications

A comparison of the measurements with biochemical markers of bone turnover and bone mineral density in the assessment of the efficiency of osteoporosis treatment

A comparison of the measurements with biochemical markers of bone turnover and bone mineral density in the assessment of the efficiency of osteoporosis treatment

Pixel-Based DXA-Derived Structural Properties Strongly Correlate with pQCT Measures at the One-Third Distal Femur Site

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