Evaluation of the effect of bimatoprost/timolol fixed combination on ocular blood flow in patients with ocular hypertension using colour Doppler imaging. Preliminary study

García-Pérez, J.L.; Puerto-Hernández, B.; Fernández, Gema Rebolleda; Muñoz‐Negrete, Francisco J.; González-Gordaliza, C.

doi:10.1016/s2173-5794(10)70026-8

Archivos de la Sociedad Española de Oftalmología (English Editi

2010

DOI: 10.1016/s2173-5794(10)70026-8

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Evaluation of the effect of bimatoprost/timolol fixed combination on ocular blood flow in patients with ocular hypertension using colour Doppler imaging. Preliminary study

J.L. García-Pérez

B. Puerto-Hernández

Gema Rebolleda Fernández

et al.

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2016

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“…No effects on CDI parameters were found for topical bimatoprost BAK, travoprost POLYQUAD, or latanoprost BAK. Some research has also revealed no changes in the blood flow in the OA in humans and rabbits in response to PGAs, although some PGAs show good results in other vascular beds, such as on the optic nerve head and in the central retinal artery (20,(22)(23)(24) . Nevertheless, our research showed that the results with travoprost are controversial.…”

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Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

Giannico¹,

Lima²,

Shaw³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Approved by the following research ethics committee: Universidade Federal do Paraná, protocol #011/2011. ABSTRACTPurpose: The aim of this study was to investigate the effects of prostaglandin analogs on blood flow in the ophthalmic artery of clinically healthy rabbits. Methods: Fifty-five clinically healthy New Zealand white rabbits were divided into six groups, and the left eyes were treated for four weeks with the preservative benzalkonium chloride (BAK) only or a topical formulation of different prostaglandin analogs (bimatoprost BAK, tafluprost BAK-free, travoprost BAK, travoprost POLYQUAD, and latanoprost BAK). Color Doppler imaging was performed before and after the treatments. The mean values of the peak systolic velocity (PSV) and end diastolic velocity and the resistive index (RI) were calculated. Statistical analysis was performed to compare the differences pre-and post-treatment for each drug and post-treatment among the drugs. Results: The prostaglandin analogs did not affect PSV. Bimatoprost BAK, travoprost POLYQUAD, and latanoprost BAK did not change RI. Tafluprost BAK-free and travoprost BAK therapy resulted in similar reductions in RI. No significant differences pre-and post-treatment were found when BAK was administered alone. Conclusion:The prostaglandin analogs tafluprost BAK-free and travoprost BAK improved blood flow in the ophthalmic artery in healthy New Zealand white rabbits, which suggests that these drugs enhance the prevention of the progression the progression of glaucoma. Keywords

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mentioning

confidence: 99%

Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

Giannico¹,

Lima²,

Shaw³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Evaluation of the effect of bimatoprost/timolol fixed combination on ocular blood flow in patients with ocular hypertension using colour Doppler imaging. Preliminary study

Cited by 1 publication

References 32 publications

Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

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