Evaluation of the Effect of Injectable Platelet-rich Fibrin on Palatal Wound Healing: A Two-arm Randomized Controlled Clinical Trial

Albatal, Wajiha; Qasem, Tarek H Abu El; Tolibah, Yasser Alsayed

doi:10.5005/jp-journals-10024-3496

The Journal of Contemporary Dental Practice

2023

DOI: 10.5005/jp-journals-10024-3496

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Evaluation of the Effect of Injectable Platelet-rich Fibrin on Palatal Wound Healing: A Two-arm Randomized Controlled Clinical Trial

Wajiha Albatal¹,

Tarek H Abu El Qasem²,

Yasser Alsayed Tolibah³

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Cited by 3 publications

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“…In addition, two studies also showed superior healing in palatal donor sites covered with A-PRF. The i-PRF showed superior results for wound healing in comparison to spontaneous healing in two studies(Albatal et al, 2023;Kızıltoprak & Uslu, 2020), but not in comparison to autologous fibrin glue(Kızıltoprak & Uslu, 2020).…”

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confidence: 99%

Wound‐healing agents for palatal donor area: A network meta‐analysis

Oliveira,

da Silveira,

Soares

et al. 2024

Clinical Oral Implants Res

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BackgroundThe aim of this systematic review and network meta‐analysis (NMA) was to assess the efficacy of different wound‐healing agents for palatal donor area management after soft tissue graft harvesting.MethodsElectronic searches in six databases were conducted for publications up to October 2023. Studies with data from patients undergoing therapeutic approaches using agents for palatal healing after gingival graft harvesting were included. Data about postoperative pain, wound‐healing and postoperative complications reported for each agent were extracted. Three different tools were used for the risk of bias within studies evaluation (Murad tool for case series and case report, RoB 2.0 tool for randomized studies and ROBINS‐I tool for non‐randomized studies). A Bayesian random effects NMA was conducted for postoperative pain levels and wound healing.ResultsEighty‐four publications were included in the systematic review (qualitative analysis), with 14 of these subjected to NMA (quantitative analysis). The summarized results from the qualitative and quantitative analysis showed that all wound‐healing agents evaluated promoted better pain control and wound healing compared to spontaneous healing and hemostatic sponges alone. The NMA outcomes reveal that leucocyte‐ and platelet‐rich fibrin (L‐PRF) was the most effective agent in reducing postoperative pain in all analyzed periods. Moreover, the L‐PRF seems to accelerate wound healing and reduce postoperative complications compared to other agents.ConclusionIn conclusion, the L‐PRF was the most effective agent in reducing postoperative pain, accelerating wound healing and reducing postoperative complications after harvesting soft tissue grafts from the palatal area.

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mentioning

confidence: 99%

Wound‐healing agents for palatal donor area: A network meta‐analysis

Oliveira,

da Silveira,

Soares

et al. 2024

Clinical Oral Implants Res

View full text Add to dashboard Cite

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Evaluation of the effect of injectable platelet-rich fibrin (i-PRF) in wound healing and growth factor release in rats: a split-mouth study

Lektemur Alpan,

Torumtay Cin,

Kızıldağ

et al. 2023

Growth Factors

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Platelet-rich fibrin in dentistry

Song,

He,

Ren

et al. 2024

Journal of Applied Biomaterials & Functional Materials

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Objectives: To review the progress of Platelet Rich Fibrin (PRF) as a biomaterial in dentistry and to highlight its promising application as a safe and biocompatible autologous platelet concentrate. Publications were searched in GeenMedical, X-mol, GoogleScholar, and PubMed from October 2024 with no language restrictions. The literature was searched for relevant databases and journals on the use of PRFs in dentistry up to October 2024, and the inclusion criteria included randomized controlled trials, clinical trials, case series, and systematic reviews. Conclusion: PRF is a second-generation platelet concentrate that is sourced from oneself, has fewer adverse effects, and is simple and safe to prepare. These materials include growth factors and fibrin scaffolds, which are extensively utilized in regenerative medicine. By outlining PRF, we found that good results can be achieved when PRF is used to treat these conditions. Clinical significance: The application of PRF in dentistry is widespread, particularly in periodontal soft and hard tissue regeneration, oral lichen planus, and pulpal regeneration. This article reviews the background, classification, and preparation methods of PRFs, along with their dental applications. We anticipate further research on various PRF derivatives in the future, which will significantly improve the utilization of PRF in oral applications and offer fresh insights for diagnosing and treating oral diseases.

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Evaluation of the Effect of Injectable Platelet-rich Fibrin on Palatal Wound Healing: A Two-arm Randomized Controlled Clinical Trial

Cited by 3 publications

References 33 publications

Wound‐healing agents for palatal donor area: A network meta‐analysis

Wound‐healing agents for palatal donor area: A network meta‐analysis

Evaluation of the effect of injectable platelet-rich fibrin (i-PRF) in wound healing and growth factor release in rats: a split-mouth study

Platelet-rich fibrin in dentistry

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