Evaluation of the Effect of SARS-COV-2 Infection During Pregnancy on Fetal Doppler Ultrasound Parameters: A Prospective Study

ÖZER, Mehmet; ÖZER, Pınar Tuğçe; OĞLAK, Süleyman Cemil; İLERİ, Alper; EMİRALİOĞLU ÇAKIR, Zübeyde; SEVER, Barış; ALDEMİR, Onur Süleyman; KANTARCI, Sercan; GÜLSEREN, Varol; PALA, Halil Gürsoy

doi:10.37990/medr.1345373

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…Moreover, Mehmet, Ö et al, 23 conducted a prospective case-control study that enrolled 81 pregnant women who had mild to moderate COVID-19 infections during their pregnancy and 70 patients who had no RT-PCR positivity or symptoms during their pregnancy to evaluate the effects of COVID-19 infection on neonatal outcomes in the late preterm period, fetal biometry, and fetal Doppler measurements and revealed that Uterine A, Umbilical A, MCA Doppler measurement (pulsatility index [PI], systolic/ diastolic ratio [S/D]), cerebroplacental ratio (CPR), amnion fluid index, head circumference, abdominal circumference, and femur length measurements performed in the late preterm period between 34 and 37 weeks, and there was no difference significantly between COVID-19 and control groups.…”

Section: Resultsmentioning

confidence: 99%

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Effect of COVID-19 infection during pregnancy on Cerebro-placental circulation (Prospective study)

Ragab,

Ali,

Bioumy

2024

HJOG

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Background: Most pregnant women who are positive for SARS-COV-2 are asymptomatic and have a low prevalence of perinatal complications. Initially, there was an overreaction concerning the potential complications of SARS-COV-2 in pregnancy, with an increase in rate of indicated preterm birth in order to avoid foetal exposure to the virus. However, now that clinical experience has accumulated, the general consensus is that only minimal or mild foetal side effects are associated with maternal SARS-COV-2 infection during pregnancy. Aim of the work: The aim of the study is to evaluate the effect of the infection with SARS- COV-2 early in pregnancy on cerebroplacental circulation. Methods: This prospective study was conducted at tertiary care hospital at ultrasound and foetal medicine unit, Ain Shams University Maternity Hospital from January 2021 till June 2023 and performed on total 283 pregnant women who had infected with SARS-COV-2 during early pregnancy (first trimester or early second trimester), compared to 283 healthy pregnant women as a control group with inclusion and exclusion criteria. Results: There were no statistically significant differences between the studied groups regarding Middle cerebral artery (MCA) pulsatility index (PI). There were no statistically significant differences between the studied groups regarding Middle cerebral artery (MCA) resistive index (RI). There were no statistically significant differences between the studied groups regarding Umbilical artery (UA) pulsatility index (PI). There were no statistically significant differences between the studied groups regarding Umbilical artery (UA) resistive index (RI). There were no statistically significant differences between the studied groups regarding cerebroplacental ratio. Conclusion: As evident from the current study, this present study reported no significant differences in fetomaternal blood flow parameters in pregnant women who had infected with SARS-COV-2 infection during early pregnancy (first trimester or early second trimester) compared to those who have not had the disease using doppler parameters of umbilical artery, middle cerebral artery and cerebroplacental ratio. In our opinion, the findings of this specific study may improve our limited knowledge for the application of Doppler ultrasound in pregnant women with COVID-19.

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Section: Resultsmentioning

confidence: 99%

“…Inclusion criteria: Pregnant women who had been infected with SARS-COV-2 infection during early pregnancy (first trimester or early second trimester), Maternal Age: -Range between 22-35 years' old and BMI (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30).…”

Section: Methodsmentioning

confidence: 99%

Effect of COVID-19 infection during pregnancy on Cerebro-placental circulation (Prospective study)

Ragab,

Ali,

Bioumy

2024

HJOG

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Evaluation of the effect of SARS-CoV-2 infection on Doppler ultrasound and placental findings of pregnant women: a systematic review and meta-analysis

Chen,

Yin,

Cai

et al. 2024

Ultrasonography

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Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect the human placenta and has been shown to have an adverse effect on Doppler ultrasound parameters and placental features. However, the specific effects of the SAS-CoV-2 infection on the fetal-placental unit in pregnant women remain unclear. The aim of this systematic review and meta-analysis was to evaluate the impact of SARS-CoV-2 infection on Doppler ultrasound and placental findings in pregnant women.Methods: A systematic search was conducted using four electronic databases (PubMed, Embase, Scopus, and Cochrane Library) to select publications published in peer-reviewed journals written in English. Odds ratios (ORs) were calculated, along with their 95% confidence intervals (CIs). Heterogeneity was assessed using Cochrane Q and I2 statistics and the appropriate P-value. The analysis used RevMan 5.3.Results: This meta-analysis included 1,210 pregnant women from 10 case-control studies. SARS-CoV-2–infected pregnant women exhibited higher likelihoods of placental abnormalities (OR, 2.62; 95% CI, 1.66 to 4.13), aberrant Doppler values (OR, 1.95; 95% CI, 1.16 to 3.27), an abnormal cerebroplacental ratio (OR, 2.68; 95% CI, 1.52 to 4.75), altered fetoplacental circulation (OR, 1.56; 95% CI, 1.07 to 2.28), and increased placental thickness and placental venous lakes (OR, 1.85; 95% CI, 1.25 to 2.72).Conclusion: According to this meta-analysis, pregnant women infected with SARS-CoV-2 are more likely to experience altered Doppler ultrasonography parameters and placental abnormalities, including increased placental thickness, placental venous lakes, altered fetoplacental circulation, and cerebroplacental ratio. However, the limited number of case-control studies requires larger sample sizes to validate and enhance the evidence.

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Evaluation of the Effect of SARS-COV-2 Infection During Pregnancy on Fetal Doppler Ultrasound Parameters: A Prospective Study

Cited by 2 publications

References 33 publications

Effect of COVID-19 infection during pregnancy on Cerebro-placental circulation (Prospective study)

Effect of COVID-19 infection during pregnancy on Cerebro-placental circulation (Prospective study)

Evaluation of the effect of SARS-CoV-2 infection on Doppler ultrasound and placental findings of pregnant women: a systematic review and meta-analysis

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