Evaluation of the effect of probiotic lozenges in the treatment of recurrent aphthous stomatitis: a randomized, controlled clinical trial

The efficacy of probiotics in management of recurrent aphthous stomatitis: a systematic review and meta-analysis

“…Aswath et al (2014) 28 did not report the gender distribution of the subjects. Three studies 23,25,26 reported the drop-out numbers as 1, 4, and 15, respectively, but there were none in the four other studies 22,24,27,28 .…”

“…The sample size ranged from 19 to 80 participants. Four studies [22][23][24][25] described the age range of the patients, ranging from 8 to 60 years, two studies 26,27 recorded the mean age that was 55.9, 28.2 in the test group and 36.4, 29.38 in the control group respectively, while the one 28 did not mention. Aswath et al (2014) 28 did not report the gender distribution of the subjects.…”

“…Aswath et al (2014) 28 advised patients in test group take anaesthetic antiseptic gel along with bifilac lozenge composed of probiotics while patients in control group take anaesthetic antiseptic gel only. In the five other studies, the intervention in the experimental group consisted of probiotics only, while the control group subjects received a placebo 22,[24][25][26][27] . Patients in studies by Mimura et al (2017) 23 and Aswath et al (2014) 28 underwent a symbiotic treatment combined with four probiotics, and Pedersen et al (2019) 25 gave patients a combination of two.…”

“…Patients in studies by Mimura et al (2017) 23 and Aswath et al (2014) 28 underwent a symbiotic treatment combined with four probiotics, and Pedersen et al (2019) 25 gave patients a combination of two. Some other studies adopted a single probiotic treatment 22,24,26,27 . Concerning the outcome measures, the evaluation assessment for the severity of ulcers are diverse and will be described in detail later.…”

“…Concerning the outcome measures, the evaluation assessment for the severity of ulcers are diverse and will be described in detail later. Three studies 23,25,26 using the visual analog (pain) scale (VAS) for the evaluation of oral pain were included in the meta-analysis; four studies 22,24,27,28 were qualitatively described.…”