Evaluation of the effect of physical therapy on pain and dysfunction of knee osteoarthritis based on fNIRS: a randomized controlled trial protocol

Abstract

Background Knee osteoarthritis (KOA) is a chronic musculoskeletal disease that can cause joint pain and dysfunction, affecting the quality of life of patients. Nonsurgical treatment is the conventional treatment of KOA, among which physical therapy is widely used because of its simplicity, convenience and effectiveness. The functional biomarker will add to the clinical fidelity and diagnostic accuracy. Therefore, our study chose a more objective evaluation indicator, functional near-infrared spectroscopy (fNIRS), to identify between healthy people and KOA patients, and to detect the pain change before and after treatment of KOA patients. Methods The study will be conducted in the Rehabilitation Medical Center of West China Hospital of Sichuan University and divided into 2 stages. In the first stage, we will compare and determine the differences in baseline data between healthy volunteers and KOA patients. In the second stage, 72 KOA patients will be randomly divided into two groups: the drug therapy group (DT) and the combination therapy group (CT) for 10 treatments. Outcome measures will be measured at baseline and on the 5th and 10th days after the intervention, including the numerical rating scale (NRS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), pain catastrophizing scale (PCS), the association of pain severity with task-state functional connectivity fNIRS and association of pain severity with task-activated fNIRS. Discussion By analyzing the fNIRS data of healthy volunteers and KOA patients, our study will be determined whether fNIRS can be used as a new indicator to reflect the severity of pain in KOA patients. Subsequently, the same fNIRS data for KOA patients before and after the intervention will be collected to provide an accurate evaluation criterion for the effect of physical therapy on KOA. Trial registration The study was registered on the Chinese Registry website (registered in ChiCTR.org with the identifiers ChiCTR2200064175 and 29/09/2022).

A feasibility study investigating cortical hemodynamic changes during infinity walk with fNIRS

“…Among non-invasive brain signal acquisition technologies, fNIRS is a non-invasive brain sensing technology with several advantages such as ease of use, portability, spatial resolution, and less prone to motion artifacts compared to other portable modalities ( Khan et al, 2021a ). The measurements obtained from fNIRS can be instrumental in enhancing therapeutic interventions, optimizing pain management strategies, and developing more effective rehabilitation and therapy plans ( Wang et al, 2023 , Mihara and Miyai, 2016 . This study uses fNIRS to measure changes in brain activity during a semi-challenging walking pattern known as the Infinity Walk, which was initially designed to improve motor function in patients with neurological disorders such as stroke.…”