Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy – A randomized controlled trial

Sage tea–thyme–peppermint hydrosol oral rinse reduces chemotherapy-induced oral mucositis: A randomized controlled pilot study

“…36 This tool categorizes grades of oral mucositis as follows: grade 0 (no mucositis); grade 1 (soreness and erythema, no further symptoms); grade 2 (ulcers present, but solid diet possible); grade 3 (ulcers present, required a liquid diet) and grade 4 (severe mucositis preventing oral nutrition and necessitating total parenteral nutrition). 36 Although the WHO oral toxicity scale has been widely used in many studies and clinical practices, 6,17,37,38,39 it has never been subjected to rigorous validation tests. Use of this empirical scale has been verified by 40 years of accumulated experiences (and the rationale for its use coincides with the opinions of most experts).…”

“…The patient questionnaire, which was developed from a questionnaire used extensively in previous studies, 6,7,19,34,35 contained questions on socio-demographic characteristics (age, gender, and educational level), patient-related risk factors (current smoking habits, daily liquid consumption, and dental prosthesis), and treatment-related risk factors (diagnosis, chemotherapy regimen, and dose). To grade oral mucositis, the WHO oral toxicity scale was utilized.…”

“…However, despite the implementation of strict mouth care procedures, patients undergoing chemotherapy regimens frequently suffer from increased incidence of oral mucositis. 6,19,20 Therefore, it is necessary to develop additional methods that complement basic oral care for the prevention of oral mucositis.…”

“…Along with high incidence, the grades of 5-FU induced oral mucositis can reach 3-4 with a ratio of 10-15%. 5,6 Oral mucositis is one of the most debilitating and troublesome toxicities, causing mouth discomfort, pain, nutritional deficits, weight loss, and the delay of treatment, leading to a low quality of life in patients undergoing chemotherapy. 2,7,8 In addition, oral mucositis poses a serious risk for the development of lifethreatening infections such as bacteremia and septicaemia.…”

Evidence based complementary and alternative methods used in the prevention and treatment of oral mucositis in cancer:Literature review

“…Çalışmaların tamamında (%100) hastalarda çeşitli seviyelerde oral mukozit geliştiği saptanmıştır. Çalışmalar sonucunda hastalarda oral mukozit insidansında [4,5,6,7,8,26,28,29,30,31,32,33], oral mukozit şiddetinde azalma görüldüğü [6,8,22,24,26,27,28,32,33,34], oral mukozitin iyileşme sürecinin hızlandığı [6,24,33], oral mukozit ilişkili enfeksiyonlarda [2] ve hastane yatış süresinde azalma olduğu [2,7], ağrıyı azalttığı [2,5,28,34] ve opioid kullanımının azaldığı [29] ve yaşam kalitesinin arttığı [22] parenteral beslenme (TPN) kullanım süresinin kısaldığı [7] ve beslenme problemlerinin azaldığı [7,28] saptanmıştır.…”