Evaluation of the effect of the interleukin-25 serum
concentration on the intensity of the symptoms of atopic
dermatitis and epidermal barrier

Basałygo, Magdalena; Sliwińska, J; Żbikowska-Gotz, Magdalena; Lis, Kinga; Socha, Ewa; Nowowiejska, Laura; Bartuzi, Zbigniew; Zegarska, Barbara

doi:10.5114/ada.2021.109686

Cited by 4 publications

(9 citation statements)

References 45 publications

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“…In addition to symptoms such as itching and soreness, HSV-1 infection poses a potentially life-threatening risk for AD patients (92). Previous study reported that the concentration of IL-25 in serum of AD patients was higher than control group (93), and IL-25 was involved in the pathogenesis of AD (94). IL-25 promoted the infection of HSV-1 among AD patients by suppressing the expression of interferongamma (IFN-g), a key factor for the host to defend against viral infection (92,95,96).…”

Section: Herpes Simplex Virus-1 (Hsv-1)mentioning

confidence: 98%

The potential roles of interleukin-25 in infectious diseases

Zhang

Tao

et al. 2022

Front. Immunol.

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Interleukin-25 (IL-25), also known as IL-17E, is a recently identified cytokine of the IL-17 family. Numerous studies illustrated that the expression of IL-25 is regulated by multiple pathogens, including parasitic, viral, and bacterial infections. IL-25 has a dual function in infectious diseases. On the one hand, IL-25 activates type 2 immunity via the relevant cytokines, including IL-4, IL-5, and IL-13, which are associated with the development of pathogenic infection-related allergic diseases. On the other hand, IL-25 involves in the recruitment of group 2 innate lymphoid cells (ILC2) to enhanced T helper 2 (Th2) cell differentiation, which are important to the clearance of pathogens. However, the precise roles of IL-25 in infectious diseases remain largely unknown. Thus, the current review will shed light on the pivotal roles of IL-25 in infectious diseases.

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Section: Herpes Simplex Virus-1 (Hsv-1)mentioning

confidence: 98%

The potential roles of interleukin-25 in infectious diseases

Zhang

Tao

et al. 2022

Front. Immunol.

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“…Six studies were included in our meta-analysis. 13,16,[18][19][20][21] Four studies reported association between IL-25 and AD. 13,[18][19][20] A total of 162 AD patients and 120 control subjects were included.…”

Section: Main Characteristics Of Studiesmentioning

confidence: 99%

“…13,16,[18][19][20][21] Four studies reported association between IL-25 and AD. 13,[18][19][20] A total of 162 AD patients and 120 control subjects were included. Among those studies, two were conducted in China 18,19 and two in Poland.…”

Section: Main Characteristics Of Studiesmentioning

confidence: 99%

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Association between IL-25, IL-33 and atopic dermatitis: A systematic review and meta-analysis

et al. 2023

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Objective: To evaluate the association between IL-25, IL-33 and AD more generally. Methods: Databases, including PubMed, Web of Science, EMBASE, Scopus, CNKI and Sinomed were searched. Based on the criteria, publications were collected. The evaluation of study quality was through Newcastle-Ottawa Scale (NOS). Fixed or random effect model was selected according to the between-study heterogeneity to evaluate the association. The analysis procedure and the construction plots were using Review Manager 5.3 software. Results: Six studies were included. A total of 282 subjects were included from four studies to analyze the association between IL-25 and AD. The level of IL-25 was significantly elevated in AD patients, comparing with the control subjects (SMD = 0.89, 95% CI: 0.64, 1.14, p < 0.05). For IL-33, a total of 247 subjects were included from two studies, and the level of IL-33 was also significantly elevated in AD patients comparing to the control subjects (SMD = 0.49, 95% CI: 0.19, 0.80, p < 0.05). Conclusions: The serum levels of IL-25, IL-33 are elevated in AD patients of this study. The IL-25 and IL-33 are significantly associated with the risk of AD. Further studies with larger samples, in multiple countries and focused on different age groups are need.

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“…Upregulation of alarmins has also been reported at the gene expression level in a recent study by Griffiths et al, where mRNA analysis of skin biopsy samples of atopic dermatitis patients and healthy individuals has shown that IL-33-related genes are elevated in both lesion and non-lesion skin samples, whereas TSLP genes are upregulated significantly in lesion compared to non-lesion skin [ 254 ]. Recent findings on the role of IL-25 in the pathology of atopic dermatitis has shown that patients with moderate and severe atopic dermatitis tend to have higher IL-25 serum concentrations [ 255 ]. It has also been reported that exogenous allergens such as house dust mite can prompt the production of IL-25 and lead to more aggravated symptoms in these patients [ 256 ].…”

Section: Alarmins and Other Allergic Diseasesmentioning

confidence: 99%

The Role of Airway Epithelial Cell Alarmins in Asthma

Whetstone

Ranjbar

Omer

et al. 2022

Cells

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The airway epithelium is the first line of defense for the lungs, detecting inhaled environmental threats through pattern recognition receptors expressed transmembrane or intracellularly. Activation of pattern recognition receptors triggers the release of alarmin cytokines IL-25, IL-33, and TSLP. These alarmins are important mediators of inflammation, with receptors widely expressed in structural cells as well as innate and adaptive immune cells. Many of the key effector cells in the allergic cascade also produce alarmins, thereby contributing to the airways disease by driving downstream type 2 inflammatory processes. Randomized controlled clinical trials have demonstrated benefit when blockade of TSLP and IL-33 were added to standard of care medications, suggesting these are important new targets for treatment of asthma. With genome-wide association studies demonstrating associations between single-nucleotide polymorphisms of the TSLP and IL-33 gene and risk of asthma, it will be important to understand which subsets of asthma patients will benefit most from anti-alarmin therapy.

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Evaluation of the effect of the interleukin-25 serum concentration on the intensity of the symptoms of atopic dermatitis and epidermal barrier

Cited by 4 publications

References 45 publications

The potential roles of interleukin-25 in infectious diseases

The potential roles of interleukin-25 in infectious diseases

Association between IL-25, IL-33 and atopic dermatitis: A systematic review and meta-analysis

The Role of Airway Epithelial Cell Alarmins in Asthma

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