Evaluation of the Effect of Nano-Sodium Alginate-Bioglass on Cardiac Function of Myocardial Infarction Based on Cardiac Ultrasound

Guan, Tao; Zhu, Xiaoyun; Lan, Tian; Shen, Tingting

doi:10.14715/cmb/2022.68.3.9

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…Huang et al introduced a procedure for manufacturing small interfering RNA (siRNA) nanoparticles (NPs) designed to selectively suppress Ca2+/calmodulin-dependent protein kinase (CaMKII) activity in macrophages. This approach offers promising prospects for treating advanced atherosclerosis and improving plaque stability [38] and also some discussed the principle mechanism of the atherosclerosis process (Figure 4).…”

Section: Small Interfering Rna (Sirna) Nanoparticles For Advanced Ath...mentioning

confidence: 99%

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Harnessing Nanotechnology for Improved Treatment for Inflammatory Cardiovascular Disorders

Fareed,

Förster,

Shityakov

2023

Preprint

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Cardiovascular disease (CVD) accounts for nearly one-third of all global fatalities, establishing itself as a leading cause of death. To address this pressing issue, there is a growing demand for improved diagnostic methods and secure, non-invasive imaging techniques that can deliver precise insights into the progression of CVD. The success of personalized therapy for CVD depends on a couple of critical factors: accurate diagnosis and early detection. Therapeutic options for conditions like CVD, which develop over several decades, are highly specific to the individual's condition and the stage of the disease. In the field of biomedicine, nanotechnology has become increasingly prominent as a tool with diverse applications, including diagnostics, biosensing, and drug delivery. This review article offers an in-depth look at the most recent developments in the utilization of nanotechnology for detecting and managing prevalent cardiovascular diseases, providing valuable insights into this crucial area of healthcare research.

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Section: Small Interfering Rna (Sirna) Nanoparticles For Advanced Ath...mentioning

confidence: 99%

“…Guan et al conducted research involving nano sodium alginate Bio-glass for the treatment of myocardial infarction (MI). Their findings indicated that this innovative approach significantly improved cardiac function, attributed to its capacity to promote cell proliferation [38].…”

Section: Nano Sodium Alginate Bioglass In Myocardial Infarction Treat...mentioning

confidence: 99%

Harnessing Nanotechnology for Improved Treatment for Inflammatory Cardiovascular Disorders

Fareed,

Förster,

Shityakov

2023

Preprint

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“…Globally, the number of deaths from cardiovascular disease increased by 41% from 1990 to 2013 [2]. Among them, acute myocardial infarction (AMI) is the highest reason for cardiovascular morbidity and mortality in the world due to acute myocardial tissue necrosis caused by persistent severe ischemia [3], which can lead to heart failure and malignant arrhythmia [4,5]. Thrombolytic and percutaneous coronary interventions can significantly improve the prognosis of patients with acute myocardial infarction.…”

Section: Introductionmentioning

confidence: 99%

Effects of the lncRNA MALAT1 gene region rs664589 site mutation on acute myocardial infarction in Chinese Han

Huamin Yu,

Sijia Tu,

Chaofeng Shen

et al. 2024

Cell Mol Biol (Noisy-le-grand)

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We aimed to study the association between the non-coding region of the lncRNA MALAT1 gene, the noncoding region rs664589 C>G variant, and the risk of acute myocardial infarction (AMI) in the Chinese Han population. 165 NSTEMI and 135 STEMI patients were enrolled in the study. An additional 150 healthy individuals were enrolled as the controls. All subjects were analyzed for the MALAT1 rs664589 locus genotype. The receiver operating curve (ROC) was used to determine the effect of MALAT1 rs664589 single nucleotide polymorphism (SNP) on the diagnosis of AMI by plasma lncRNA MALAT1. The MALAT1 rs664589 site G allele carrier was 1.39 times more likely to have NSTEMI than the C allele carrier (95% CI: 1.16-1.61, P = 0.001) and 1.59 times more likely to have STEMI than the C allele carrier (95% CI: 1.31-1.85, P < 0.001). The MALAT1 rs664589 site C>G mutation resulted in an increase in the area under the ROC curve (AUC) of the plasma lncRNA MALAT1 level for the diagnosis of AMI. The plasma lncRNA MALAT1 levels in AMI patients were negatively correlated with hsa-miR-1972, hsa-miR-194-5p, hsa-miR-4717-5p, hsa-miR-6735-3p, and hsa-miR-3677-5p (r = -0.81, -0.75, -0.66, -0.71, and -0.88). The C>G mutation of MAL6641 rs664589 causes an increased risk of AMI in the Chinese Han population. The SNP at this site affects the value of plasma lncRNA MALAT1 in the diagnosis of AMI. The specific mechanism may indicate that the C>G mutation of the MALAT1 rs664589 changes the regulation of miRNAs expression by lncRNA MALAT1.

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“…Tissue engineering is a field of study that encompasses various areas of knowledge, and biocompatibility, biodegradability, shear behavior, rapid gelation, and an easy cross-linking process make alginate one of the most studied polysaccharides in this area [1]. One of the most daunting challenges in human healthcare involves the restoration of damaged or degenerated tissues and the replacement of failed or-gans, posing significant obstacles for modern medicine [2].…”

Section: Introductionmentioning

confidence: 99%

Sodium Alginate/PRP Matrices for Prostaglandin Release in Acute Myocardial Infarction

Barbosa,

Simeoni,

Koh

et al. 2024

Rev. Contemp.

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Tissue engineering is a multidisciplinary field, and biocompatibility, biodegradability, shear behavior, rapid gelation, and an easy cross-linking process make alginate one of the most extensively studied polysaccharides in this area. Myocardial infarction represents the leading cause of death worldwide. Recently, peroxisome proliferator-activated receptors (PPARs) have garnered research interest due to their role in modulating inflammation. 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) has demon-strated significant antinociceptive and anti-inflammatory activity. In the pursuit of a shorter and less invasive drug delivery system, a biodegradable matrix was sought. Leveraging the characteristics of alginate and platelet-rich plasma (PRP) as biode-gradable biomaterials with suitable physicochemical and biological properties for this application, this study aimed to develop an alginate and PRP biomaterial for prosta-glandin release. Platelet-Rich Plasma (PRP) was obtained by concentrating platelets through centrifugation. The biomaterial, in the form of membranes, was prepared using the casting method from polymeric solutions with a concentration of 4.0% (w/v), with PRP added in proportions of 10% relative to the mass of sodium alginate (SA). The preformed membranes were immersed in aqueous solutions of 1% CaCl2 (w/v) to promote SA cross-linking and subsequent drug incorporation. In vitro bioac-tivity was evaluated by immersion in simulated body fluid. The SEM assay demon-strated that the incorporation of SA/PRP/PGJ occurred uniformly. Therefore, the results suggest the potential use of alginate and PRP films for prostaglandin release, but pre-clinical studies are still required.

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Evaluation of the Effect of Nano-Sodium Alginate-Bioglass on Cardiac Function of Myocardial Infarction Based on Cardiac Ultrasound

Cited by 5 publications

References 22 publications

Harnessing Nanotechnology for Improved Treatment for Inflammatory Cardiovascular Disorders

Harnessing Nanotechnology for Improved Treatment for Inflammatory Cardiovascular Disorders

Effects of the lncRNA MALAT1 gene region rs664589 site mutation on acute myocardial infarction in Chinese Han

Sodium Alginate/PRP Matrices for Prostaglandin Release in Acute Myocardial Infarction

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