Evaluation of the effectiveness of combination therapy of recurrent anogenital (venereal) warts: results of an observational comparative clinical study

Abstract

Background. Destruction of anogenital warts lead to their removal, but do not eliminate the risk of their recurrence. In case of recurrent forms of the disease, combination therapy with the use of inducers interferons may be recommended. Aims: to study the effectiveness of topical application of polysaccharides of Solanum tuberosum shoots (Panavir gel, 0.002%) in the combined therapy of recurrent anogenital warts. Methods: 60 patients with recurrent anogenital warts: group 1 (n=30) underwent radiowave destruction and therapy with Panavir gel, 0.002% externally 2 times a day for 5 days before and 10 days after destruction), group 2 (n=30) – radiowave destruction. The patients were monitored for 3 months. Results. Absence of itching and pain in the destruction zone by day 5 was recorded in 27 (90.0%) patients of group 1 and 12 (40.0%) patients of group 2, after 10 days – in 30 (100%) and 26 (86.7%) (χ2=4,285). Inflammatory erythema, edema and infiltration were absent after 10 days in all patients of group 1, but persisted in 7 (23,3%), 12 (40,0%) and 2 (6.7%) patients of group 2 (χ2=7,924). Epithelialization was observed for 5 days in 18 (60.0%) patients of group 1 and 10 (33.3%) patients of group 2, after 10 days in 30 (100%) and 28 (93.3%) patients (χ2=4,285). 90 days after therapy, relapses of the disease were recorded in 2 (6.7%) patients of group 1 and 6 (20.0%) patients of group 2 (p=0,499), HPV elimination was observed in 11 (36.7%) and 10 (33.3%) patients (p=0,967). Conclusions. The effectiveness of the use of Panavir gel, 0.002% in the complex therapy of anogenital warts has been established in terms of reducing the severity of subjective and objective symptoms of inflammation in the affected areas, the timing of tissue epithelialization after destruction, as well as reducing the frequency of recurrence of rashes