Evaluation of the Effectiveness of Telfairia occidentalis Leave Extracts in the Amelioration of Carbon Tetrachloride Induced Liver Injuries and Oxidative Damage in Rats

Owoade, Abiodun Olusoji; Aborisade, Abiodun Bukunmi; Adetutu, Adewale; Olurunnisola, Olubukola

doi:10.9734/jamps/2016/29199

Cited by 3 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As revealed in the results section, S. siamea in a concentration and timedependent manner scavenges DDPH and ABTS radicals. Antioxidant generally possesses the ability to donate a hydrogen atom to free radicals, S. siamea leaves extract in this study most likely act as an antioxidant by donating hydrogen to free radicals [32]. The ability of S. siamea to reduce ferric-tripyridyltriazine (Fe 3+ -TPTZ) complex to ferrous-tripyridyltriazine (Fe 2+ -TPTZ) in a concentration-dependent manner further highlights that it possesses antioxidant potential in the amelioration of free radicals into stable and less deleterious products.…”

Section: Discussionmentioning

confidence: 78%

Antioxidant Potentials, Phytochemical Profiles and Ameliorating Effects of Senna siamea Extract on Arsenic-Induced Hepato-Renal Damage

Owoade

Alausa

Adetutu

et al. 2021

AJRB

Self Cite

View full text Add to dashboard Cite

This study evaluated the in- vitro antioxidant, phytochemical constituents and hepato-renal protective efficacy of Senna siamea methanolic extract in arsenic-induced oxidative stress. The results of this study show that S. siamea has strong antioxidant potentials against 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 2,2’azinobis (3 ethylbenzothiazoline-6-sulphonic acids) (ABTS) radicals. The extract scavenges nitric oxide radicals and has strong ferric reducing power. It also inhibited the induction of lipid peroxidation and α-amylase activity in a concentration-dependent manner. Administration of arsenic to rats induced a significant increase in the levels of alanine aminotransferase, aspartate aminotransferase, cholesterol, urea, creatinine, and triglycerides in the plasma, while it decreased superoxide dismutase, glutathione and catalase activities in the liver and kidney. It also significantly reduced the levels of white blood cells, red blood cells, platelet and lymphocytes in the blood. However, rats pretreated with S. siamea extract before arsenic administration significantly reversed all these arsenic-induced changes. Histological observations showed varying degrees of liver damage in the arsenic group that was untreated, while the pre-treatment with S. siamea extract significantly improved the general histoarchitecture of the liver. The phytochemical constituents of the extract were determined, the gas-chromatography analysis revealed the possible presence of oxalic acid, barakol, kaempferol, betulin while total phenolics content, crude protein, crude fat, crude fibre are in considerable amount in the plant This study demonstrated that S. siamea extract has antioxidant potentials and ameliorates arsenic-induced hepato-renal toxicity, the effectiveness of S. siamea as a medicinal plant could be due to the presence of various phenolics and antioxidant compounds in the plant.

show abstract

Section: Discussionmentioning

confidence: 78%

Antioxidant Potentials, Phytochemical Profiles and Ameliorating Effects of Senna siamea Extract on Arsenic-Induced Hepato-Renal Damage

Owoade

Alausa

Adetutu

et al. 2021

AJRB

Self Cite

View full text Add to dashboard Cite

show abstract

“…One major source of natural antioxidants is plants, and interest in phytochemicals of plant origin that serve as natural antioxidants has been increasing because they are viewed as potential therapeutic drugs for the treatment of reactive species-mediated diseases [4]. The risk of developing reactive species-mediated diseases is significantly reduced when the diet is plantbased with a high level of vegetables and fruits [5,1].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Constituents and Comparative Antioxidative Effects of Some Medicinal Plants

Owoade

Adetutu

Ogundipe

et al. 2021

JOCAMR

Self Cite

View full text Add to dashboard Cite

This study was carried out to compare the in-vitro antioxidant potentials, antidiabetic and phytochemical constituents of methanolic leaf extracts of Anthocleista djalonensis, Chrysophyllum albidium, Bauhinia thonningii, Daniellia oliveri, and Cola nitida. The results of this study show that all the plant extracts have strong antioxidant potentials against various radicals. The extracts scavenged DPPH and ABTS radicals, in a concentration-dependent manner and scavenged nitric oxide radicals with IC50 values of 152.39, 186.36, 213.40, 303.58 and 355.53 µg/ml for C. albidium, D. oliveri, C. nitida, A. djalonensis and B. thonningii, respectively. All the extracts also inhibited the induction of lipid peroxidation and α-amylase activity in a concentration-dependent manner, while the degree of ferric reducing power by the extracts was of the order C. albidium > D. oliveri > B. thonningii > C. nitida > A. djalonensis. Phytochemical and gas chromatography analyses carried out on the extracts revealed the presence of known chemical constituents. The amounts of total phenolics in A. djalonensis, C. albidium, B. thonningii, D. oliveri, and C. nitida were 68.39 mg/g, 95.11 mg/g, 61.03 mg/g, 103.74 mg/g, and 63.31 mg/g, respectively, in gallic acid equivalents. In all cell-free assays, C. albidium and D. oliveri, the two plants with higher amounts of phenolic compounds, were found to be more effective as antioxidants than other plant extracts with lower phenolic contents under the same experimental conditions. Therefore, the effectiveness of the antioxidant and antidiabetic activities of these plant extracts may be related to their phenolic content. The presence of phenolics and various antioxidant compounds in the plants may explain the strong pharmacological potentials of these plants.

show abstract

Turmeric as a therapeutic agent against arsenic-induced metabolic dysregulation in rat models

Adetutu,

Aborisade,

Olaniyi

2024

Pharmacological Research - Natural Products

View full text Add to dashboard Cite

Evaluation of the Effectiveness of Telfairia occidentalis Leave Extracts in the Amelioration of Carbon Tetrachloride Induced Liver Injuries and Oxidative Damage in Rats

Cited by 3 publications

References 19 publications

Antioxidant Potentials, Phytochemical Profiles and Ameliorating Effects of Senna siamea Extract on Arsenic-Induced Hepato-Renal Damage

Antioxidant Potentials, Phytochemical Profiles and Ameliorating Effects of Senna siamea Extract on Arsenic-Induced Hepato-Renal Damage

Phytochemical Constituents and Comparative Antioxidative Effects of Some Medicinal Plants

Turmeric as a therapeutic agent against arsenic-induced metabolic dysregulation in rat models

Contact Info

Product

Resources

About