Evaluation of the effectiveness of different indicator PCBs to estimating total PCB concentrations in environmental investigations

Megson, David; Benoit, Nadine; Sandau, Courtney D.; Chaudhuri, Sri R.; Long, Tanya; Coulthard, Emma; Johnson, Glenn W.

doi:10.1016/j.chemosphere.2019.124429

Cited by 55 publications

(18 citation statements)

References 53 publications

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“…Together these findings support the need for extensive PCB congener testing and reporting from environmental mixtures. Inclusion of a wide number of congeners would allow for a better assessment of total mixture exposure rather than reporting indicator PCBs ( Lehmann et al, 2015 ), which is common in studies but often deemed inappropriate (e.g., ( Gandhi et al, 2015 ; Megson et al, 2019 ). For the application of the NEQ scheme to previously gathered data that report on select indicator congeners, additional uncertainty considerations may be needed.…”

Section: Discussionmentioning

confidence: 99%

Non-dioxin-like polychlorinated biphenyl neurotoxic equivalents found in environmental and human samples

Holland

Pessah

2021

Regulatory Toxicology and Pharmacology

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Non-dioxin like polychlorinated biphenyls (NDL PCB) are recognized neurotoxicants with implications on altered neurodevelopment and neurodegeneration in exposed organisms. NDL PCB neurotoxic relative potency schemes have been developed for a single mechanism, namely activity toward the ryanodine receptor (RyR), or combined mechanisms including, but not limited to, alterations of RyR and dopaminergic pathways. We compared the applicability of the two neurotoxic equivalency (NEQ) schemes and applied each scheme to PCB mixtures found in environmental and human serum samples. A multiple mechanistic NEQ predicts higher neurotoxic exposure concentrations as compared to a scheme based on the RyR alone. Predictions based on PCB ortho categorization, versus homologue categorization, lead to a higher prediction of neurotoxic exposure concentrations, especially for the mMOA. The application of the NEQ schemes to PCB concentration data suggests that PCBs found in fish from US lakes represent a considerable NEQ exposure to fish consuming individuals, that indoor air of schools contained high NEQ concentrations representing an exposure concern when inhaled by children, and that levels already detected in the serum of adults and children may contribute to neurotoxicity. With further validation and in vivo exposure data the NEQ scheme would help provide a more inclusive measure of risk presented by PCB mixtures.

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Section: Discussionmentioning

confidence: 99%

Non-dioxin-like polychlorinated biphenyl neurotoxic equivalents found in environmental and human samples

Holland

Pessah

2021

Regulatory Toxicology and Pharmacology

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“…The present study investigated the seven PCB contaminants (PCB-28, PCB-52, PCB-101, PCB-118, PCB-138, PCB-153, PCB-180) present commonly in soil, among which PCB-118 is a member of the class of dioxin-like polychlorinated biphenyls [25]. Three representative functional enzymes (water channel enzyme (6QIM), biphenyl dioxygenase (3GZX) and lignin peroxidase Downloaded from http://portlandpress.com/biochemj/article-pdf/doi/10.1042/BCJ20210104/908807/bcj-2021-0104.pdf by guest on 10 May 2021 Biochemical Journal.…”

Section: Characterization Of Cbs Binding To Plant-microbe Enzyme Using Molecular Dockingmentioning

confidence: 99%

Enhanced plant-microbe remediation of PCBs in soil using enzyme modification technique combined with molecular docking and molecular dynamics

Li¹,

He²,

Liu

2021

Biochemical Journal

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The study on the enhanced mechanisms of the enzymes involved in plant absorption, plant degradation, and microbial mineralization in the remediation of soils contaminated with polychlorinated biphenyls (PCBs) is of great significance for the application of plant-microbe combined remediation technique in PCB-contaminated soils. The present study first used a combination of molecular docking and molecular dynamics methods to calculate the effects of the plant absorption enzyme, plant degradation enzyme, and microbial mineralization enzyme on the PCBs in the soil environment. A multifunctional plant degradation enzyme was constructed with three functional roles of absorption, degradation, and mineralization using amino acid sequence recombination and site-directed mutagenesis to modify the template of plant degradation enzyme. Finally, using the Taguchi experimental design-assisted molecular dynamics simulation method, the suitable external environmental conditions of plant-microbe combined remediation of the PCB-contaminated soil were determined. In total, six multifunctional plant degradation enzymes were designed, which exhibited a significantly improved efficiency of PCB degradation. In comparison to the complex of plant absorption enzyme, plant degradation enzyme, and microorganism mineralization enzyme (6QIM-3GZX-1B85), the six multifunctional plant degradation enzymes exhibited significantly higher efficiency (2.10–2.38 times) in degrading the PCBs, with a maximum of 2.69 times under suitable external environmental conditions.

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“…The presence of PCBs in surface waters of background regions is usually associated with one dominant source: global atmospheric transport. Assessment of the surface water pollution with PCBs, based on the concentration of indicator congeners in such regions, gives adequate results [24].…”

Section: Articlesmentioning

confidence: 99%

Determination of Indicator Congeners of Polychlorinated Biphenyls in Water at Ultratrace Levels by Gas Chromatography–Tandem Mass Spectrometry

Kustova

Stepanov²,

Горшков

2021

J Anal Chem

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We validated a procedure for the determination of indicator congeners (ICs) of polychlorinated biphenyls (PCBs) (IUPAC nos. 28, 52, 101, 118, 138, 153, and 180) in water at an ultratrace concentration level in the range from 0.02 to 0.90 ng/L. The procedure includes collecting 1-L samples, extraction of PCBs with n-hexane, preconcentration of the extracts (k conc = 10 4 ), and the direct analysis of the preconcentrates by gas chromatography-tandem mass spectrometry. The chromatographic separation of the preconcentrates in columns with a carborane stationary phase (HT-8, 30 m), the detection of analytical peaks in the selected reaction monitoring mode, and the use of ICs labeled with 13 C as surrogate internal standards ensured the high reliability of peak identification and the accuracy of quantitative determination with a total error (±δ, P = 0.95) of 35%. The procedure was tested in monitoring PCBs in the aquatic ecosystem of Lake Baikal, and the concentrations of ICs were determined in the upper water layer of the pelagic zone and the lake's tributaries.

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Evaluation of the effectiveness of different indicator PCBs to estimating total PCB concentrations in environmental investigations

Cited by 55 publications

References 53 publications

Non-dioxin-like polychlorinated biphenyl neurotoxic equivalents found in environmental and human samples

Non-dioxin-like polychlorinated biphenyl neurotoxic equivalents found in environmental and human samples

Enhanced plant-microbe remediation of PCBs in soil using enzyme modification technique combined with molecular docking and molecular dynamics

Determination of Indicator Congeners of Polychlorinated Biphenyls in Water at Ultratrace Levels by Gas Chromatography–Tandem Mass Spectrometry

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