2012
DOI: 10.12938/bmfh.31.37
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Evaluation of the Effects of Dietary Organic Germanium, Ge-132, and Raffinose Supplementation on Caecal Flora in Rats

Abstract: Poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132) is the most common organic germanium compound. The ingestion of Ge-132 promotes bile secretion. We assessed the rat caecal characteristics after the administration of Ge-132 and raffinose, a prebiotic oligosaccharide, because both Ge-132 and some prebiotics can change the fecal color to yellow. We also compared the changes in the caecal flora caused by the two compounds. In addition, we evaluated the simultaneous administration of Ge-132 and raffinose and… Show more

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Cited by 8 publications
(11 citation statements)
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“…Nakamura et al reported that the increase of IgA secretion in the mucosa of the lower intestine was remarkable in mice fed FOS [ 1 ] and indicated that the changes in the intestinal environment mediated by the intestinal microbiota were involved. Actually, feeding of indigestible carbohydrates such as FOS [ 6 ], raffinose [ 7 ] and RMD [ 5 ] resulted in a severalfold increase of cecum weight due to fermentation in the cecum in rodents. Since consumption of RMD increased the cecal content and it is speculated that the intestinal content stays longer in the cecum of rodents, it is likely that increased IgA production by the cecal mucosa also contributed to the increase in IgA amount in the intestinal tract in the 7.5% RMD group.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Nakamura et al reported that the increase of IgA secretion in the mucosa of the lower intestine was remarkable in mice fed FOS [ 1 ] and indicated that the changes in the intestinal environment mediated by the intestinal microbiota were involved. Actually, feeding of indigestible carbohydrates such as FOS [ 6 ], raffinose [ 7 ] and RMD [ 5 ] resulted in a severalfold increase of cecum weight due to fermentation in the cecum in rodents. Since consumption of RMD increased the cecal content and it is speculated that the intestinal content stays longer in the cecum of rodents, it is likely that increased IgA production by the cecal mucosa also contributed to the increase in IgA amount in the intestinal tract in the 7.5% RMD group.…”
Section: Discussionmentioning
confidence: 99%
“…Intake of prebiotics increases SCFAs in the lower intestine, but the patterns of their changes vary depending on the kinds of prebiotics. FOS intake increases acetic acid and butyric acid [ 1 ], and raffinose intake increases formic acid and acetic acid and decreases butyric acid [ 7 ]. RMD intake significantly increased butyric acid in the cecum in this study, and it has been reported that RMD intake resulted in increased butyric acid in feces in humans [ 4 ].…”
Section: Discussionmentioning
confidence: 99%
“…Although the inorganic form of germanium is toxic, the organic form is used in the treatment of some diseases [68]. This organic form is synthesized by the Asai Germanium Research Institute in Tokyo [69].…”
Section: Germanium (Ge)mentioning
confidence: 99%
“…Ge-132 is widely used as it belongs to the non-toxic active substances, and the acute toxicity or chronic toxicity is very low [10]. Consequently, it has been used as an ingredient in health foods and supplements in many countries nowadays [13]. …”
Section: -Carboxyethyl Germanium Sesquioxide (Ge-132)mentioning
confidence: 99%