Evaluation of the Effects of Gamma Radiation Sterilization on Rhein-Loaded Biodegradable Microparticles for the Treatment of Osteoarthritis

Avendaño-Godoy, Javier; Problete, Maria Gabriela; Ramos, Ricardo Godoy; Gómez-Gaete, Carolina

doi:10.1016/j.xphs.2022.11.003

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…The results showed that the sterilization process did not have any major impact on the relevant properties of the microspheres loaded with drugs and no change in the in vitro release curve. In conclusion, gamma radiation is a suitable sterilization method, and intra-articular delivery of microparticle formulations also offers a promising therapeutic option for patients suffering from chronic joint disease ( Avendaño-Godoy et al, 2023 ). Dhanabalan et al ( Dhanabalan et al, 2020 ; Dhanabalan et al, 2023 ) also developed MPs encapsulating rapamycin using PLGA as a carrier.…”

Section: Application Of Polymeric Microparticles (Mps) In Knee Osteoa...mentioning

confidence: 99%

Recent advances in polymeric microparticle-based drug delivery systems for knee osteoarthritis treatment

Wang,

Zhang,

Kapilevich

et al. 2023

Front. Bioeng. Biotechnol.

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Due to the poor bioavailability and high joint clearance of drugs, sustained delivery of therapeutic agents has proven difficult in the treatment of osteoarthritis (OA). Intra-articular (IA) drug delivery strategy is an attractive option for enhancing OA patients’ prognosis, for which various polymer materials have been used as drug carriers due to their attractive delivery properties, to slow or even reverse the progress of OA by prolonging the duration of therapeutic agent residence in the joint. This article focuses on the recent developments in natural and synthetic polymer-based microsphere drug delivery systems for treating knee osteoarthritis. It evaluates the translational potential of some novel formulations for clinical application.

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Section: Application Of Polymeric Microparticles (Mps) In Knee Osteoa...mentioning

confidence: 99%

Recent advances in polymeric microparticle-based drug delivery systems for knee osteoarthritis treatment

Wang,

Zhang,

Kapilevich

et al. 2023

Front. Bioeng. Biotechnol.

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Intramuscularly Administered PLGA Microparticles for Sustained Release of Rivastigmine: In Vitro, In Vivo and Histological Evaluation

Avendaño-Godoy¹,

Miranda²,

Mennickent³

et al. 2023

Journal of Pharmaceutical Sciences

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Recent advancements in microspheres mediated targeted delivery for therapeutic interventions in osteoarthritis

Rohila,

Shukla

2024

Journal of Microencapsulation

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Evaluation of the Effects of Gamma Radiation Sterilization on Rhein-Loaded Biodegradable Microparticles for the Treatment of Osteoarthritis

Cited by 3 publications

References 53 publications

Recent advances in polymeric microparticle-based drug delivery systems for knee osteoarthritis treatment

Recent advances in polymeric microparticle-based drug delivery systems for knee osteoarthritis treatment

Intramuscularly Administered PLGA Microparticles for Sustained Release of Rivastigmine: In Vitro, In Vivo and Histological Evaluation

Recent advancements in microspheres mediated targeted delivery for therapeutic interventions in osteoarthritis

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