Evaluation of the effects of Citrus sinensis seed oil on blood glucose, lipid profile and liver enzymes in rats injected with alloxan monohydrate

Chilaka, Kingsley Chimsorom; Ifediba, Emeka Chinedu; Ogamba, JO

doi:10.1016/s2221-6189(15)30022-6

Cited by 9 publications

(8 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The result of this study showed that ALT levels were generally reduced in all test groups with group 4 significantly reduced compared to control. This shows that Citrullus lanatus seed oil does not have an adverse effect on the liver integrity and this agrees with the report of Chilaka, Ifediba, and Ogamba [6], on the evaluation of the effect of Citrus sinensis seed oil on liver enzymes in rats. Alkaline Phosphatases (ALP) are a group of isoenzymes that act to dephosphorylate a variety of molecules throughout the body.…”

Section: Discussionsupporting

confidence: 92%

Functional and Histomorphological Assessments of Liver and Kidney in Matured Female Albino Wistar Rats Following Ingestion of Citrullus lanatus Seed Extracts

Ifon

Ndifon

Ekaidem

2018

IJBCRR

View full text Add to dashboard Cite

Oil from different seeds in fruits has been exploited for nutritional and health benefits ranging from provision of essential nutrients for cellular metabolic processes to being an alternative route to the orthodox drugs in the quest for a better living. However, adverse consequences following consumption of this seed oils on both the liver and kidney are not well known. The present study was carried out to assess the integrity of the liver and kidney following the administration of different doses of Citrullus lanatus seed extracts (oil) to mature female albino Wistar rats. Twenty -four female albino Wistar rats weighing between 179 g -257 g were randomly divided into four groups of six animals per group. Animals in group 1(control group) received normal rat chow placebo. The experimental groups 2, 3, and 4 received 932.0 mg, 1864.0 mg and 2796.0 mg seed oil extract / kg

show abstract

Section: Discussionsupporting

confidence: 92%

Functional and Histomorphological Assessments of Liver and Kidney in Matured Female Albino Wistar Rats Following Ingestion of Citrullus lanatus Seed Extracts

Ifon

Ndifon

Ekaidem

2018

IJBCRR

View full text Add to dashboard Cite

show abstract

“…Previously, a reduction of blood glucose in alloxan-induced diabetic rats was observed after treatment with emulsified sweet orange seed oil (1000 mg/kg BW). In addition, this seed oil improved sugar and lipid profile with reduction of serum TG, cholesterol, and increased HDL-cholesterol in diabetic rats (Chilaka et al, 2015).…”

Section: Metabolic Syndromementioning

confidence: 87%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

View full text Add to dashboard Cite

Citrus is the most cultivated fruit crop in the world and occupies a place of considerable importance in the country’s economy. Almost 33% of the citrus fruits are processed for juice production; however, a great amount of wastes, including peels, segment membranes, and seeds are also produced. Indeed, citrus fruits consist of 45% juice, 26% pulp, 27% peels, and 2% seeds. Pruning, a cultural practice involving the removal of tree branches and limbs, was applied to improve fruit’s quality. A large amount of leaves are produced through pruning. These agri-food matrices contain a wide range of bioactive phytochemicals compared to fruits. The present review covers the past 5 years of research carried out in chemistry, health properties, and applications in food and nutraceutical industries of all portions of citrus fruit and its major bioactive compounds. Additionally, patents are also included.

show abstract

“…Most of the studies used a pathological model of chronic diseases. Overall, 35.7% of the studies used genetically and chemically induced diabetic rats (Ahmad et al, 2013;Chilaka et al, 2015;Ahmed et al, 2017;Luka et al, 2017;Gosslau et al, 2018); another 35.7% of studies used rat models induced by ingestion of high-fat diets with chemical induction by streptozotocin or alloxan (Muhtadi et al, 2015;Liu et al, 2016;Sathiyabama et al, 2018;Srivastava, 2018;Rekha et al, 2019); one study used rats with diet-induced metabolic syndrome (Mayneris-Perxachs et al, 2019); two studies used hyperglycemic and hypercholesterolemic rodents (Ashraf et al, 2017;Fayek et al, 2017); and one study evaluated the effect of orange bagasse in healthy rats (Macagnan et al, 2015).…”

Section: Characteristics Of Animal Modelsmentioning

confidence: 99%

“…Experimental groups with 4-10 rats per group were integrated; 57% of the studies had groups composed of six animals. Wistar rats were used in most of the studies (Ahmad et al, 2013;Chilaka et al, 2015;Macagnan et al, 2015;Muhtadi et al, 2015;Ahmed et al, 2017;Fayek et al, 2017;Luka et al, 2017;Sathiyabama et al, 2018;Srivastava, 2018;Rekha et al, 2019), followed by Sprague Dawley (Liu et al, 2016;Ashraf et al, 2017), OFA (Mayneris-Perxachs et al, 2019), and Zucker diabetic fatty rats (Gosslau et al, 2018). Male rodents were used in 92.85% of the studies, and one study used rats of both sexes (Srivastava, 2018).…”

Section: Characteristics Of Animal Modelsmentioning

confidence: 99%

“…Peel was the most used by-product (Ahmad et al, 2013;Muhtadi et al, 2015;Liu et al, 2016;Ahmed et al, 2017;Ashraf et al, 2017;Fayek et al, 2017;Luka et al, 2017;Gosslau et al, 2018;Sathiyabama et al, 2018;Srivastava, 2018;Mayneris-Perxachs et al, 2019;Rekha et al, 2019), and some studies also used seed (Chilaka et al, 2015) and bagasse (Macagnan et al, 2015). In most research studies, an extract from the by-product was used, including methanolic, alcoholic, hexane, hydroethanolic, and aqueous extracts, whereas in other studies, a part of the by-product was obtained, for example, pectin from orange peel.…”

Section: Orange By-product Interventionmentioning

confidence: 99%

See 1 more Smart Citation

The biological effect of orange (Citrus sinensis L.) by-products on metabolic biomarkers: A systematic review

Pineda-Lozano

Fonseca-Bustos

Moreno

et al. 2022

Front. Sustain. Food Syst.

View full text Add to dashboard Cite

Industrial processing of citrus fruits generates an important amount of wastes that evoke environmental damage. Orange is the main citrus fruit consumed worldwide, and after its use, approximately more than a half of the fruit remains as by-products, which comprise important bioactive compounds useful for the development of promising nutraceuticals for the treatment of non-communicable diseases. This study aimed to gather scientific evidence about the biological effects of orange by-products using a systematic review. A total of 14 studies that were carried out in rodent models in the last 10 years were retrieved from PubMed and ScienceDirect databases. Studies that used another animal species, another type of citrus, or a combination of orange with other citrus were excluded. The risk of bias was assessed by using the SYRCLE RoB tool, and the results obtained are shown in an informative table, which showed that most of the studies used a pathological model of chronic diseases. We found that the peel is the most used agri-food by-product, and that it has the potential of reducing the levels of triglycerides, total cholesterol, glucose, and systolic blood pressure. However, to clinically assess these effects, these results need to be tested in future in humans. The included studies on the use of orange by-products strengthen the global sustainable food agenda. It is important to consider new research directions about the use of citrus fruit residues since it not only impacts the problem of its disposal but also provides solutions to eliminate the resulting contamination.

show abstract

Evaluation of the effects of Citrus sinensis seed oil on blood glucose, lipid profile and liver enzymes in rats injected with alloxan monohydrate

Cited by 9 publications

References 13 publications

Functional and Histomorphological Assessments of Liver and Kidney in Matured Female Albino Wistar Rats Following Ingestion of Citrullus lanatus Seed Extracts

Functional and Histomorphological Assessments of Liver and Kidney in Matured Female Albino Wistar Rats Following Ingestion of Citrullus lanatus Seed Extracts

Citrus species: Modern functional food and nutraceutical-based product ingredient

The biological effect of orange (Citrus sinensis L.) by-products on metabolic biomarkers: A systematic review

Contact Info

Product

Resources

About