Evaluation of the Effects of Restraint and Footshock Stress on Small Intestinal Motility by an Improved Method Using a Radionuclide, &lt;SUP&gt;51&lt;/SUP&gt;Cr, in the Rat

Tsukada, Fumitake; Sugawara, Mika; Kohno, Hiroyuki; Ohkubo, Yasuhito

doi:10.1248/bpb.24.488

Cited by 14 publications

(4 citation statements)

References 22 publications

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“…These factors have been shown to significantly affect the efficacy of exercise in several studies [82–84]. Additionally, foot shock and immobilization have been shown to result in different behavioral and physiological reactivity to stress [85–88]. …”

Section: Discussionmentioning

confidence: 99%

Chronic forced exercise inhibits stress-induced reinstatement of cocaine conditioned place preference

Robison¹,

Alessi

Thanos³

2018

Behavioural Brain Research

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Stress increases the likelihood of cocaine relapse in humans and animals, even following a prolonged extinction/abstinence period. Exercise has previously been shown to reduce stress and decrease the likelihood of drug dependence, while also reducing cravings in humans and inhibiting relapse behaviors due to other risk factors in rodents. The present study evaluated the efficacy of exercise to reduce stress-induced relapse to cocaine in a rodent model. Young adult female Sprague Dawley rats were tested for cocaine conditioned place preference (CPP), then split into sedentary or exercise (six weeks of one-hour daily treadmill running, five days per week) groups. Following cocaine CPP, rats were tested for extinction behavior, and then tested for stress-primed reinstatement (15 min immobilization) following the six-week intervention period. Exercise inhibited stress-induced reinstatement of cocaine CPP despite increasing serum corticosterone levels following 15 min of immobilization, suggesting that chronic aerobic exercise intervention may result in adaptations of stress pathways. These findings suggest that exercise may help prevent stress-induced drug relapse, adding to a growing body of evidence supporting the utility of exercise to combat substance abuse.

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Section: Discussionmentioning

confidence: 99%

Chronic forced exercise inhibits stress-induced reinstatement of cocaine conditioned place preference

Robison¹,

Alessi

Thanos³

2018

Behavioural Brain Research

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“…59,60 Such an increase in colonic motility is only a temporary effect of stress, and the normal flow is recovered after chronic stress. 61 Because the motility of the small intestine was not affected by stress (Online Figure VII) and this intestinal segment was the end point location where M-RCT was measured, it follows that our data were not affected by a change in intestinal motility.…”

Section: Discussionmentioning

confidence: 99%

Acute Psychological Stress Accelerates Reverse Cholesterol Transport via Corticosterone-Dependent Inhibition of Intestinal Cholesterol Absorption

Silvennoinen

Escolà-Gil

Julve

et al. 2012

Circulation Research

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Rationale: Psychological stress is associated with an increased risk of cardiovascular diseases. However, the connecting mechanisms of the stress-inducing activation of the hypothalamic-pituitary-adrenal axis with atherosclerosis are not well-understood. Objective: To study the effect of acute psychological stress on reverse cholesterol transport (RCT), which transfers peripheral cholesterol to the liver for its ultimate fecal excretion. Methods and Results: C57Bl/6J mice were exposed to restraint stress for 3 hours to induce acute psychological stress. RCT in vivo was quantified by measuring the transfer of [ 3 H]cholesterol from intraperitoneally injected mouse macrophages to the lumen of the small intestine within the stress period. Surprisingly, stress markedly increased the contents of macrophage-derived [ 3 H]cholesterol in the intestinal lumen. In the stressed mice, intestinal absorption of [ 14 C]cholesterol was significantly impaired, the intestinal mRNA expression level of peroxisome proliferator–activated receptor-α increased, and that of the sterol influx transporter Niemann-Pick C1–like 1 decreased. The stress-dependent effects on RCT rate and peroxisome proliferator–activated receptor-α gene expression were fully mimicked by administration of the stress hormone corticosterone (CORT) to nonstressed mice, and they were blocked by the inhibition of CORT synthesis in stressed mice. Moreover, the intestinal expression of Niemann-Pick C1–like 1 protein decreased when circulating levels of CORT increased. Of note, when either peroxisome proliferator-activated receptor α or liver X receptor α knockout mice were exposed to stress, the RCT rate remained unchanged, although plasma CORT increased. This indicates that activities of both transcription factors were required for the RCT-accelerating effect of stress. Conclusions: Acute psychological stress accelerated RCT by compromising intestinal cholesterol absorption. The present results uncover a novel functional connection between the hypothalamic-pituitary-adrenal axis and RCT that can be triggered by a stress-induced increase in circulating CORT.

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“…Small intestinal transit (SIT) function was determined 3 days after catheter implantation on fasted rats as previously described 24,25 . Briefly, after light constraint, rats were injected i.v.…”

Section: Methodsmentioning

confidence: 99%

Peripheral and central administration of exogenous urocortin 1 disrupts the fasted motility pattern of the small intestine in rats via the corticotrophin releasing factor receptor 2 and a cholinergic mechanism

Yin¹,

Dong²,

Yin³

2008

J of Gastro and Hepatol

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Evaluation of the Effects of Restraint and Footshock Stress on Small Intestinal Motility by an Improved Method Using a Radionuclide, <SUP>51</SUP>Cr, in the Rat

Cited by 14 publications

References 22 publications

Chronic forced exercise inhibits stress-induced reinstatement of cocaine conditioned place preference

Chronic forced exercise inhibits stress-induced reinstatement of cocaine conditioned place preference

Acute Psychological Stress Accelerates Reverse Cholesterol Transport via Corticosterone-Dependent Inhibition of Intestinal Cholesterol Absorption

Peripheral and central administration of exogenous urocortin 1 disrupts the fasted motility pattern of the small intestine in rats via the corticotrophin releasing factor receptor 2 and a cholinergic mechanism

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