Evaluation of the effects of Iranian propolis on the severity of post operational-induced peritoneal adhesion in rats

Askari, Vahid Reza; Rahimi, Vafa Baradaran; Zamani, Parvin; Fereydouni, Narges; Rahmanian-Devin, Pouria; Sahebkar, Amirhosein; Rakhshandeh, Hassan

doi:10.1016/j.biopha.2018.01.068

Cited by 47 publications

(52 citation statements)

References 43 publications

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“…In this study, we used the scraping model due to the similarity between the adhesion formed by this model and by abdominopelvic surgery. Moreover, we used Nair scoring, which scores adhesions on a 0-4 grade [14]. Our results showed that the control group markedly enhanced the adhesion score and R. officinalis (4 %) notably diminishes the Nair adhesion grade following post-operational-induced peritoneal adhesion.…”

Section: Discussionmentioning

confidence: 79%

Evaluation of the Effects of Peritoneal Lavage with Rosmarinus officinalis Extract against the Prevention of Postsurgical-Induced Peritoneal Adhesion

et al. 2020

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Postoperative adhesions are regarded as the major complication following abdominal surgery. Rosmarinus officinalis has shown antioxidative and anti-inflammatory effects. Therefore, we aimed to assess the influence of 70% v/v hydro-ethanolic extract of the aerial parts of R. officinalis against postoperative abdominal adhesions in a rat model. Forty-eight male Wistar rats (190 ± 20 g) were divided into six groups of eight: group 1 = normal group, without any surgical procedures, group 2 = control group, group 3 = vehicle group, and groups 3, 4, and 5 = experimental groups receiving 2 mL of 4, 2, or 1% w/v R. officinalis treatment. Adhesion levels were macroscopically examined. Additionally, the levels of inflammatory cytokines (interleukin-6, interleukin-1β, and TNF-α), growth factors (transforming growth factor-β1, and vascular endothelial growth factor), oxidative (NO, nitric oxide and MDA, malondialdehyde), and antioxidative (GSH, glutathione) factors were evaluated. Our results revealed that the adhesion score, interleukin-6, interleukin-1β, TNF-α, transforming growth factor-β1, vascular endothelial growth factor, NO, and MDA levels were significantly increased in the vehicle group, while the GSH level was diminished. R. officinalis treatment notably ameliorated the adhesion score following postoperative abdominal adhesions compared with the vehicle group. Our results also revealed that R. officinalis markedly reduced inflammatory cytokines, oxidative factors, fibrosis, and angiogenesis biomarkers, whereas it increased the antioxidative factor. Therefore, R. officinalis may be a potential candidate for the management of postoperative peritoneal adhesion.

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Section: Discussionmentioning

confidence: 79%

Evaluation of the Effects of Peritoneal Lavage with Rosmarinus officinalis Extract against the Prevention of Postsurgical-Induced Peritoneal Adhesion

et al. 2020

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“…Inflammation is a set of processes causing by different types and levels of cytokines, growth factors, NO, and prostaglandins, which are produced by activated macrophages and other immune system cells (Askari, Baradaran Rahimi, et al, ; Askari, Rahimi, et al, ; Askari & Shafiee‐Nick, ; Kianmehr et al, ; Rahimi et al, ; Rahimi, Askari, Shirazinia, et al, ). In this section, the antiinflammatory effects of pomegranate and EA and their possible mechanisms have been discussed by details.…”

Section: Resultsmentioning

confidence: 99%

“…In the past decades, focuses on the medicinal plants and their isolated compounds have been propagated due to the increased tendency of patients to the herbal medicines. In addition, more than half of the anticancer drugs were isolated from natural sources such as plants, microorganisms, and aquatic resources (Abbasi et al, ; Askari et al, ; Askari, Baradaran Rahimi, et al, ). Punica granatum (pomegranate) belongs to the Punicaceae , which has been used for several medical purposes from ancient and in different cultures.…”

Section: Introductionmentioning

confidence: 99%

Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

Rahimi

Ghadiri

Ramezani

et al. 2020

Phytotherapy Research

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Inflammation is commonly characterized as a defensive and protective reaction of the body to various exogenous or endogenous stimuli, which aims to maintain the body health. Punica granatum (pomegranate) and its constituent ellagic acid (EA) are recently more taken into accounts since their promising pharmacological effects. Therefore, we aimed to obtain a comprehensive review regarding antiinflammatory, anticancer, and antioxidant activities of both pomegranate and EA and their possible involved mechanisms. In the procedure, scientific databases, including Web of Science, PubMed, Scopus, and Google Scholar, were searched in the English language, until the end of January 2019. Pomegranate belonging to the Punicaceae has been used for medical purposes from ancient and in different cultures. Several studies have also supported that EA is the major active compound of pomegranate and possesses antimutagenic, antiinflammatory, antifibrosis, anticancer, and antiaging properties. It has been suggested that pomegranate and EA possess promising immunomodulatory effects in preclinical models as well as human studies through regulation of the T‐cell function and suppressing humoral immunity. Hopefully, we wish that this review and information could be helpful for designing further experiments to investigate the potential protective effects of pomegranate and EA.

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“…Phenol mucilage is widely used for establishing the in ammation-induced adhesion animal model in IUA [21,29,30] and other various medical studies, such as peritoneal adhesion [31], cervicitis [32], pelvic in ammatory [33], et al for its high effectivity and reliability. Phenol mucilage contains 3 toxic ingredients, including lique ed phenol, Arabic gum, and glycerin.…”

Section: Discussionmentioning

confidence: 99%

Decreased CXCL5 expression associated with intrauterine adhesions in a rat model and human endometrial tissues

Sun

Fang

Gao

et al. 2020

Preprint

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Background Intrauterine adhesion (IUA) is a consequence of endometrium damage, leading to infertility, recurrent miscarriage, and various complications of pregnancy. IUA usually occurs after an infection or injury-related inflammation of the endometrium. CXCL5, a member of chemokines, is associated with the remodeling of connective tissues, but its roles in the formation of IUA remain uncertain. This study aims to investigate the expression and effect of CXCL5 in the development of IUA. Results CXCL5 protein level in the endometrium of IUA rat is significantly decreased compared with that in normal and sham-operated endometria of rats (P < 0.001). Furthermore, real-time PCR and western blotting assays also show that the CXCL5 expression in endometrial tissues from IUA patients is much lower than that in normal endometrium (P < 0.01), which is consistent with the results based on the rat model. CXCL5 significantly up-regulates MMP9 expression and slightly up-regulates p65 expression in human endometrial cells after CXCL5 overexpression. Conclusions These results show that CXCL5 plays an important role in the inhibition of IUA formation after injury by modulating MMP9 expression and therefore has a protective effect of CXCL5 in the adhesion formation of IUA. These findings provide valuable information for evaluating prognosis and guiding therapy of intrauterine adhesions.

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Evaluation of the effects of Iranian propolis on the severity of post operational-induced peritoneal adhesion in rats

Cited by 47 publications

References 43 publications

Evaluation of the Effects of Peritoneal Lavage with Rosmarinus officinalis Extract against the Prevention of Postsurgical-Induced Peritoneal Adhesion

Evaluation of the Effects of Peritoneal Lavage with Rosmarinus officinalis Extract against the Prevention of Postsurgical-Induced Peritoneal Adhesion

Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

Decreased CXCL5 expression associated with intrauterine adhesions in a rat model and human endometrial tissues

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