Evaluation of the Effects of Plant‐derived Essential Oils on Central Nervous System Function Using Discrete Shuttle‐type Conditioned Avoidance Response in Mice

Umezu, Toyoshi

doi:10.1002/ptr.3665

Cited by 23 publications

(29 citation statements)

References 37 publications

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“…Inhalation of Alpinia zerumbet essential oil, which contains 1,8-cineole, had anxiolytic effects in mice [22]. The essential oils of eucalyptus were found to decrease the avoidance rate in mice without affecting their response on a discrete shuttle-type task, a type of conditioned avoidance task [23]. In agreement with previous findings in mice, our results indicate that 1,8-cineole may exert anxiolytic effects in humans.…”

Section: Discussionsupporting

confidence: 89%

The Effect of 1,8‐Cineole Inhalation on Preoperative Anxiety: A Randomized Clinical Trial

Kim

Seo

Min

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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The aim of this study was to investigate the effect of inhalation of eucalyptus oil and its constituents on anxiety in patients before selective nerve root block (SNRB). This study was a randomized controlled trial carried out in 62 patients before SNRB. The patients were randomized to inhale limonene, 1,8-cineole, or eucalyptus oil, each at concentrations of 1% vol/vol in almond oil or almond oil (control). Anxiety-visual analog scale (A-VAS), state-trait anxiety inventory (STAI), profile of mood states (POMS), pain-visual analog scale (P-VAS), blood pressure, and pulse rate were measured before and after inhalation prior to SNRB. Measures of anxiety, including A-VAS (P < 0.001), STAI (P = 0.005), and POMS (P < 0.001), were significantly lower in 1,8-cineole than in the control group and significantly greater in 1,8-cineole than in the eucalyptus group in A-VAS. P-VAS was significantly lower after than before inhalation of limonene, 1,8-cineole, and eucalyptus, despite having no significant difference in the four groups compared with control group. 1,8-Cineole, a major constituent of eucalyptus, was effective in decreasing anxiety before SNRB. The present findings suggest that inhalation of 1,8-cineole may be used to relieve anxiety before, during, and after various operations, in addition to SNRB.

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Section: Discussionsupporting

confidence: 89%

The Effect of 1,8‐Cineole Inhalation on Preoperative Anxiety: A Randomized Clinical Trial

Kim

Seo

Min

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…Kuribara et al [20] demonstrated that the discrete shuttle-type conditioned avoidance task in mice is useful for distinguishing CNS stimulants and CNS depressants; that is, CNS stimulants facilitate the avoidance response and CNS depressants suppress the avoidance response in mice performing this task. Using the discrete shuttle-type conditioned avoidance task in ddY mice, I have previously shown that EOs of peppermint and chamomile facilitate the avoidance response as well as CNS stimulants and that EOs of orange, cypress, grapefruit, eucalyptus and rose suppress the avoidance response as well as CNS depressants [26]. However, the results of some EOs in the study were disagree with the claims for their effects made by the previous studies [12,13,[15][16][17]19].…”

Section: Introductioncontrasting

confidence: 59%

Evaluation of Central Nervous System Acting Effects of Plant-Derived Essential Oils Using Ambulatory Activity in Mice

Umezu¹

2013

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Although plant-derived essential oils (EOs) have traditionally been used for treating various kinds of mental disorders, their Central Nervous System (CNS) acting effects have not yet been clarified well. The present study examined effects of 30 kinds of EOs on ambulatory activity, a kind of spontaneous motor activity, in ICR mice. Nineteen kinds of them did not produce any significant effects on the ambulatory activity of mice. Although effects of EOs of lavender, jasmine and neroli on the activity were statistically significant, their CNS acting properties remained unclear. EOs of peppermint, chamomile, thyme, tea tree, rosemary and basil significantly increased the ambulatory activity of mice as well as CNS stimulants, suggesting that they possess CNS stimulant-like effects. In contrast, an EO of myrtle significantly decreased the activity as well as CNS depressants, suggesting that it possesses a CNS depressant-like effect. An EO of palmarosa significantly increased the activity at a lower dose and decreased at a higher dose as well as some kinds of CNS depressants such as ethanol, suggesting that it also possesses a CNS depressant-like effect. These 8 kinds of EOs might be useful for treating some kinds of mental troubles and/or symptoms through their CNS acting effects.

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“…Thus, EOs obtained from various kinds of plant species and their constituents could show CNS effects. This notion is supported by the previous studies including those from our laboratory that have shown that various kinds of EOs and their constituents produce a variety of behavioural and/or CNS effects after inhalation or peripheral administration.…”

Section: Introductionsupporting

confidence: 68%

“…The absence of apigenin in CHA is likely one of the reasons for the absence of a sedative effect on ambulation . a suppressive effect on the conditioned avoidance response and an anxiolytic effect in the conflict tests …”

Section: Discussionmentioning

confidence: 99%

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Identification of isobutyl angelate, isoamyl angelate and 2‐methylbutyl isobutyrate as active constituents in Roman chamomile essential oil that promotes mouse ambulation

Umezu

Sano

Hayashi

et al. 2017

Flavour & Fragrance J

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Roman chamomile (Chamaemelum nobile or Anthemis nobilis) has traditionally been used for health care, health maintenance and medicinal purposes, and the essential oil obtained from the flowers is used as a basic ingredient for aromatherapy. Roman chamomile essential oil (CHA) produces psychostimulant‐like effects, such as the ambulation‐promoting effect, on mouse behaviour. However, mechanisms underlying the effects of CHA remain unclear. The present study aimed to identify the constituents responsible for the ambulation‐promoting effect of CHA and to elucidate a possible neuronal mechanism. GC/MS analysis revealed that isobutyl angelate, isoamyl angelate and 2‐methylbutyl isobutyrate were the major constituents of CHA. These compounds significantly promoted mouse ambulation, and were thus identified as the major active constituents for the ambulatory effect of CHA. The ambulatory effects were attenuated by chlorpromazine and haloperidol, suggesting that the neurotransmitter dopamine is involved in the ambulation‐promoting effects of these constituents similar to already‐known psychostimulants. The results suggest that CHA can change a mental condition, at least in part, through the CNS effects of the constituents identified in the current study. The results also suggest that mental effects of CHA are largely different from those of other Roman chamomile preparations due to the composition difference.

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Evaluation of the Effects of Plant‐derived Essential Oils on Central Nervous System Function Using Discrete Shuttle‐type Conditioned Avoidance Response in Mice

Cited by 23 publications

References 37 publications

The Effect of 1,8‐Cineole Inhalation on Preoperative Anxiety: A Randomized Clinical Trial

The Effect of 1,8‐Cineole Inhalation on Preoperative Anxiety: A Randomized Clinical Trial

Evaluation of Central Nervous System Acting Effects of Plant-Derived Essential Oils Using Ambulatory Activity in Mice

Identification of isobutyl angelate, isoamyl angelate and 2‐methylbutyl isobutyrate as active constituents in Roman chamomile essential oil that promotes mouse ambulation

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