Evaluation of the efficacy and safety of loratadine in perennial allergic rhinitis

Oral antihistamines for the symptom of nasal obstruction in persistent allergic rhinitis – a systematic review of randomized controlled trials

“…Bousquet et al [14] found no statistically significant reduction in ‘stuffiness’ in patients on antihistamines compared with placebo. Bruttman et al [15] found that nasal stuffiness improved in 50% patients on loratadine, 41% on terfenadine and 13% on placebo. Mansmann et al [16] found a statistically significant reduction in ‘stuffiness’ in patients on Cetirizine 20 mg od ( P <0.01 compared with placebo), but not on Cetirizine 10 mg od.…”

Treatment of congestion in upper respiratory diseases

“…In a study of adults with seasonal allergic rhinitis, loratadine was associated with greater improvements in nasal stuffiness score at day 4 and overall versus placebo, although the differences were not statistically significant for either comparison 24. A 4-week trial in adults with perennial allergic rhinitis showed that loratadine 10 mg once daily and terfenadine 60 mg twice daily both significantly reduced nasal stuffiness compared with placebo 43. A pooled analysis of 3 studies in children with seasonal allergic rhinitis showed that fexofenadine 30 mg twice daily significantly reduced all nasal symptoms versus placebo, including congestion,44 and a separate study in adults with seasonal allergic rhinitis reported that fexofenadine 120 mg once daily for 2 weeks significantly reduced nasal congestion score versus placebo 45.…”

Allergic Rhinitis: Efficient Therapeutic Opportunities

“…Иммунотерапия используется в тех случаях, если у пациента неэффективна фармакотерапия. Чаще всего назначаются интраназальные глюкокортико-стероиды, блокаторы Н1-гистаминовых рецепторов и антагонисты лейкотриенов, т. к. эффективность этих пре-паратов была доказана в исследованиях как при сезон-ном, так и при круглогодичном АР [9][10][11].…”