Evaluation of the Efficacy and Safety of Tranexamic Acid for Reducing Blood Loss in Bilateral Total Knee Arthroplasty

Effect of intravenous tranexamic acid on blood loss and blood transfusion in total knee replacement: a prospective, randomized study in Indian population

“…37 In another study, bilateral primary TKR surgeries were examined retrospectively in 87 patients by comparing 37 patients who were given TXA infusions of 20 mg/kg before incision to the 50 patients in the control group and blood transfusion was found to fall from 50% to 11%. 25 Since we obtained similar findings to these in the patients given systemic TXA in our study, we think that TXA can be used systemically to decrease intraoperative and postoperative blood loss. Several studies have compared local and systemic applications of TXA as well and although they have concluded that amounts of blood loss and the need for blood transfusion are reduced at similar rates in the postoperative period, controversial results have been reported with regard to local and systemic applications of TXA.…”

“…21,22 TXA has been applied locally or systemically. [23][24][25] This study was aimed to ascertain the effectiveness of tranexamic acid in minimizing the intra operative and postoperative blood loss in total knee arthroplasty.…”

Comparison of clinical results for patients undergoing unilateral total knee replacement with or without tranexamic acid

“…5 Several studies have reported that intravenous (IV) TEA administration is safe and has a beneficial clinical effect in terms of reducing blood loss. [6][7][8] Of all these clinical results, there is no evident increase in medication-related complications, such as pulmonary emboli and bleeding tendency. Therefore, this study was designed to analyze the clinical results of IV TEA use in patients undergoing unilateral primary TKA.…”

Transfusion Cost Savings with Tranexamic Acid in Primary Total Knee Arthroplasty from 2009 to 2012

“…TXA therapy has been applied to total joint arthroplasty with similar reduction in transfusion rates [1][2][3][4][5][6][7][8][9][10][11][12]. There are also several risks secondary to blood transfusion that are reduced or removed when TXA is employed: transfusion reactions, infections, fluid overload and altered mental status; all of which may lead to prolonged hospitalization [1,4,10,13].…”