Evaluation of the efficacy and safety of etoricoxib in the treatment of hemophilic arthropathy

Tsoukas, Christos; Eyster, M. Elaine; Shingo, Sumiko; Mukhopadhyay, Snehasis; Giallella, Karen M.; Curtis, Sean; Reicin, Alise; Melian, Agustin

doi:10.1182/blood-2004-09-3501

Cited by 48 publications

(44 citation statements)

References 21 publications

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“…Recent studies have reported on the effective use of COX-2 inhibitors, which do not interfere with platelet function, to treat patients with haemophilia (Rattray et al, 2005(Rattray et al, , 2006Tsoukas et al, 2006). A double-blind, placebocontrolled study demonstrated superior efficacy of etoricoxib compared with placebo to treat pain in patients with haemophilic arthropathy (Tsoukas et al, 2006). However, further evaluation of the safety and efficacy of these drugs in patients with haemophilia is needed, particularly because of the concerns of increased cardiovascular events associated with some of these drugs.…”

Section: Analgesiamentioning

confidence: 99%

“…However, others have reported increased bruising and gastrointestinal bleeding (Daly & Scott, 1984;Cagnoni & Aledort, 1994). Recent studies have reported on the effective use of COX-2 inhibitors, which do not interfere with platelet function, to treat patients with haemophilia (Rattray et al, 2005(Rattray et al, , 2006Tsoukas et al, 2006). A double-blind, placebocontrolled study demonstrated superior efficacy of etoricoxib compared with placebo to treat pain in patients with haemophilic arthropathy (Tsoukas et al, 2006).…”

Section: Analgesiamentioning

confidence: 99%

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Modern management of haemophilic arthropathy

2007

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SummaryCurrently available factor concentrates for treatment of patients with haemophilia are virally inactivated or are made by recombinant technology and their broad use in developed nations has resulted in the dramatic elimination of the treatment‐related viral illnesses that decimated the haemophilia community in the late 20th century. The major morbidity experienced by patients with haemophilia today is joint disease, a result of repeated bleeding episodes into joint spaces. Although administration of factor concentrates to prevent bleeding has been demonstrated to prevent haemophilic joint disease when applied assiduously, repeated bleeding episodes induce synovitis that is irreversible and may progress despite subsequent prophylaxis. Surgical and nuclear medicine interventions are available to reduce the pain of haemophilic arthropathy and to reduce further bleeding episodes. Patients with high titre inhibitors are at great risk for the development of joint disease and present the greatest therapeutic challenges when joint surgery is needed.

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Section: Analgesiamentioning

confidence: 99%

Section: Analgesiamentioning

confidence: 99%

Modern management of haemophilic arthropathy

2007

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“…• s preventivnim dajanjem manjkajočega faktorja v odmerkih, ki preprečujejo krvavitve (146,147); • z intenzivno fizioterapevtsko obravnavo za okrepitev mišic in povečanje stabilnosti sklepov, kar učinkovito izvaja le fizioterapevt z dodatnimi znanji s področja fizioterapije pri hemofiliji (148,149); • z nesteroidnimi protivnetnimi analgetiki in COX-2 inhibitorji (Tabela 12), ki lahko zmanjšajo vnetje (150,151).…”

Section: Kronični Sinovitisunclassified

Nacionalna priporočila za obravnavo bolnikov s hemofilijo

et al. 2017

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The document presents recommendations for the comprehensive treatment of patients with haemophilia in Slovenia. It enables health workers at all three levels of health care to become well-acquainted with all the possible aspects of treatment based on the best practices of major centres worldwide, and on the studies and experience of health professionals at the National Haemophilia Centre, University Medical Center Ljubljana. The document contains definitions, treatment algorithms and lists of medications with their characteristics and appropriate dosages. It specifically defines indications for the exclusive competence of the tertiary level in Ljubljana due to the actual availability of teams and laboratory options. It also contains an extensive list of the literature on haemophilia.

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“…Paracetamol and opioids may be used safely. The use of cyclo-oxygenase-2 inhibitors such as celecoxib may be considered certain circumstances [7,8], but this needs to be discussed in advance with the haemophilia team.…”

Section: Peri-operative Analgesiamentioning

confidence: 99%

Surgery in patients with inherited bleeding disorders

Mensah

Gooding

2014

Anaesthesia

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SummaryIt is estimated that up to 1% of the general population has a congenital bleeding disorder. With this level of disease burden, it is more likely than not that any practising surgeon or anaesthetist will, at one time or another, have occasion to manage one such patient. Congenital haemophilia, both A and B, von Willebrand's disease, and inherited qualitative platelet defects, constitute the bulk of these disorders, with the rest distributed between much rarer conditions. Although looking after such patients will continue to pose a challenge to anaesthetists, recent and continuing advances in haemostatic products, coupled with increasing awareness of haemostatic care, means that surgery in this challenging group of patients is safer now than ever before, and can now be undertaken with a degree of confidence not possible even two decades ago. Central to these recent successes has been the continuing evolution of specialised healthcare services; in particular, Haemophilia Comprehensive Care Centres. Of equal importance, at least in developed countries, has been the ease of access to highly purified, safe and effective haemostatic products. The key to successful surgical management of the patient with a bleeding disorder is a multidisciplinary approach involving not only surgeons, anaesthetists and haematologists, but also laboratory scientists, specialist physiotherapists and haemophilia nurses. With careful planning, most surgical and invasive procedures can be carried out safely in persons with haemophilia and other bleeding disorders.

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Evaluation of the efficacy and safety of etoricoxib in the treatment of hemophilic arthropathy

Cited by 48 publications

References 21 publications

Modern management of haemophilic arthropathy

Modern management of haemophilic arthropathy

Nacionalna priporočila za obravnavo bolnikov s hemofilijo

Surgery in patients with inherited bleeding disorders

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