Evaluation of the efficacy of topical caffeine in the treatment of psoriasis vulgaris

Vali, Anahita; Asilian, Ali; Khalesi, Elaheh; Khoddami, Leila; Shahtalebi, Mohammadali; Mohammady, Maryam

doi:10.1080/09546630510011801

Cited by 25 publications

(12 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Micellar paclitaxel significantly improved psoriasis in a prospective phase II study [53]. A study reported significant effectiveness of topical caffeine [54]. “Calcium channel blocker” nifedipine is found to be inductor of the disease in a case control study [55].…”

Section: Resultsmentioning

confidence: 98%

Novel Factors in the Pathogenesis of Psoriasis and Potential Drug Candidates Are Found with Systems Biology Approach

Manczinger

Kemény

2013

PLoS ONE

View full text Add to dashboard Cite

Psoriasis is a multifactorial inflammatory skin disease characterized by increased proliferation of keratinocytes, activation of immune cells and susceptibility to metabolic syndrome. Systems biology approach makes it possible to reveal novel important factors in the pathogenesis of the disease. Protein-protein, protein-DNA, merged (containing both protein-protein and protein-DNA interactions) and chemical-protein interaction networks were constructed consisting of differentially expressed genes (DEG) between lesional and non-lesional skin samples of psoriatic patients and/or the encoded proteins. DEGs were determined by microarray meta-analysis using MetaOMICS package. We used STRING for protein-protein, CisRED for protein-DNA and STITCH for chemical-protein interaction network construction. General network-, cluster- and motif-analysis were carried out in each network. Many DEG-coded proteins (CCNA2, FYN, PIK3R1, CTGF, F3) and transcription factors (AR, TFDP1, MEF2A, MECOM) were identified as central nodes, suggesting their potential role in psoriasis pathogenesis. CCNA2, TFDP1 and MECOM might play role in the hyperproliferation of keratinocytes, whereas FYN may be involved in the disturbed immunity in psoriasis. AR can be an important link between inflammation and insulin resistance, while MEF2A has role in insulin signaling. A controller sub-network was constructed from interlinked positive feedback loops that with the capability to maintain psoriatic lesional phenotype. Analysis of chemical-protein interaction networks detected 34 drugs with previously confirmed disease-modifying effects, 23 drugs with some experimental evidences, and 21 drugs with case reports suggesting their positive or negative effects. In addition, 99 unpublished drug candidates were also found, that might serve future treatments for psoriasis.

show abstract

Section: Resultsmentioning

confidence: 98%

Novel Factors in the Pathogenesis of Psoriasis and Potential Drug Candidates Are Found with Systems Biology Approach

Manczinger

Kemény

2013

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…In psoriasis patients, serum as well as epidermis, adenosine deaminase levels were significantly elevated (Bü kü lmez et al, 2000) and may reflect the accelerated salvage pathways of nucleic acid metabolism associated with the hyperproliferative epidermis (Koizumi et al, 1983). Based on the results of a trial, it was concluded that caffeine, a P1 adenosine receptor antagonist, ''is an effective, safe and inexpensive treatment for psoriasis'' (Vali et al, 2005), as in psoriatic epidermis, the level of cAMP decreases and caffeine increases concentrations of intracellular cAMP.…”

Section: Skin Pathology Psoriasismentioning

confidence: 97%

Purinergic Signaling in Healthy and Diseased Skin

Burnstock

Knight

Greig

2012

Journal of Investigative Dermatology

124

133

View full text Add to dashboard Cite

Adenosine 5'-triphosphate and adenosine receptors have been identified in adult and fetal keratinocytes, fibroblasts, melanocytes, mast cells, Langerhans cells, and Meissner's corpuscles, as well as in hair follicles, sweat glands, and smooth muscle and endothelial cells of skin vessels. Purinergic signaling is involved in skin pathology, including inflammation, wound healing, pain, psoriasis, scleroderma, warts, and skin cancer.

show abstract

“…Caffeine has been proposed as a potential treatment for dermatological conditions such as psoriasis [135], viral infections [136,137] and cellulite treatment [138,139]. Iontophoresis has also demonstrated the ability to enhance the epidermal delivery of macromolecules (up to 10 kDa) [140].…”

Section: Iontophoresismentioning

confidence: 99%

Topical Dermatological Drug Delivery: Quo Vadis?

Akomeah

2010

CDD

View full text Add to dashboard Cite

Skin disease (dermatological conditions') affects at least one-third of the US population and has been cited as one of the top 15 medical conditions for which prevalence and healthcare spending increased in the last decade. The outcome of topical dermatological drug treatment is significantly influenced by the choice of vehicle or delivery system. Advancements in the life sciences coupled with a growing market for dermatologicals have facilitated the emergence of improved topical formulations and drug delivery systems. The current and emerging approaches of optimizing the topical delivery of dermatological agents (small and large molecules) include the use of chemical enhancers, bio-polymers (e.g. sodium hyaluronate), liposomes, particulate carriers (microspheres and lipid nanoparticles), topical sprays and foams, occlusion (via dressings and patches) topical peels, temperature (heat), iontophoresis and ultrasound. These delivery approaches (when used solely or in a synergistic manner) are a significant improvement over conventional systems (creams, lotions, ointments and pastes) and have the potential to enhance efficacy and tolerability, improve patient compliance (including dermatology life quality), and also fulfil other unmet needs of the topical dermatological market.

show abstract

Evaluation of the efficacy of topical caffeine in the treatment of psoriasis vulgaris

Abstract: Based on the results of the trial, topical caffeine is an effective, safe and inexpensive treatment for psoriasis, with a delay in action.

Cited by 25 publications

References 3 publications

Novel Factors in the Pathogenesis of Psoriasis and Potential Drug Candidates Are Found with Systems Biology Approach

Novel Factors in the Pathogenesis of Psoriasis and Potential Drug Candidates Are Found with Systems Biology Approach

Purinergic Signaling in Healthy and Diseased Skin

Topical Dermatological Drug Delivery: Quo Vadis?

Contact Info

Product

Resources

About