Evaluation of the efficacy of topical rifamycin application on postoperative complications after lower impacted wisdom teeth surgery

Ciğerim, Levent; ORHAN, Zeynep Dilan; KAPLAN, Volkan; Ciğerim, Saadet Çınarsoy; Feslihan, Erkan

doi:10.1016/j.jormas.2023.101501

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…The removal of necrotic debris or food particles via irrigation is hypothesized to eliminate potential sources of inflammation and pain [6,13]. Moreover, when extraction sockets are irrigated with rifamycin, there is an evidence suggesting reduction in the incidence of alveolitis, prevention of infection, and the induction of analgesia following surgical removal of impacted third molars [13,14].…”

Section: Introductionmentioning

confidence: 99%

Effect of a Single Dose of Deflazacort on Postoperative Pain, Swelling and Trismus after Impacted Lower Third Molar Surgery

Kaplan,

Ciğerim,

Feslihan

et al. 2024

Preprint

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Background and Objectives: The complications seen after lower impacted third molar surgery affect the quality of life of the patients. The aim of the study was to investigate the efficacy of a single preoperative dose of deflazacort on pain, swelling and trismus following impacted lower third molar surgery. Materials and Methods: This randomised, prospective, double-blind, split-mouth clinical study included 30 healthy individuals with bilaterally impacted lower third molars that was removed for orthodontic purposes between September 2017 and September 2018. Group 1 was given a placebo (single dose vitamin C tablet) and group 2 was given a single 30 mg dose of deflazacort 1 hour prior to the surgery. Pain was evaluated using the visual analog scale for 1 week postoperatively. Edema (in mm) and trismus (in mm) were evaluated preoperatively and on postoperative days 2 and 7. The Mann-Whitney U test was applied for group analysis. p values < 0.05 were considered statistically significant. Results: When postoperative pain scores were evaluated, a significant difference was found between the groups only at the 6th and 12th hours (p0.05). Even high trismus values were recorded on the 2nd day, it was observed that the trismus resolved on the 7th day. There were no significant differences in trismus between the groups at any time point (p>0.05). Evaluation of swelling showed that there was no statistically significant difference between the study and control groups at any time point (p>0.05). No side effect was detected in both the study and the control groups. Conclusions: This was the first split-mouth study evaluating the anti-inflammatory effect of deflazacort after lower impacted third molar surgery. A single dose of 30 mg deflazacort was shown to be effective in reducing pain at 6 and 12 hours postoperatively.

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Section: Introductionmentioning

confidence: 99%

Effect of a Single Dose of Deflazacort on Postoperative Pain, Swelling and Trismus after Impacted Lower Third Molar Surgery

Kaplan,

Ciğerim,

Feslihan

et al. 2024

Preprint

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Selective Outcome Reporting Concerning Antibiotics and Third Molar Surgery

Fagoni,

Rafalovich,

Brozoski

et al. 2024

Preprint

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Objectives This study evaluates the selective outcome reporting (SOR) in clinical trials on antibiotic use in third molar surgeries. It explores how SOR may bias results and affect systematic reviews, potentially leading to misinterpretations of intervention efficacy. Materials and Methods A search was conducted on "ClinicalTrials.gov" and the "Brazilian Registry of Clinical Trials" using the terms "third molar" and "antibiotics" up to October 2024. Two independent researchers selected eligible clinical trials. Data were extracted from registered protocols and corresponding publications. Discrepancies were analysed using established criteria, and the risk of bias was assessed with Risk of Bias2. Results Discrepancies between protocols and publications were found in 83.3% of cases, affecting outcomes in 58.3% of studies. SOR significantly influenced results in studies with three or more discrepancies. Seventy percent of studies assess pain post-antibiotic therapy; of those, 50% found significant results. Only 30% of studies showed significant reductions in trismus and edema with antibiotic use. Risk of bias varied significantly across studies. Conclusions The high rate of selective reporting stresses the need for transparent studies to clarify the role of antibiotics in the perioperative period. Researchers should adhere to best clinical practices, including protocol registration, accurate sample size calculations, and precision in reporting. Journals and reviewers must prioritize transparency to reduce bias and improve research quality. Clinical Relevance This study emphasizes the impact of SOR in clinical trials using antibiotics in third molar surgery. Clinicians should be more cautious in reading evidence based on randomized clinical trials with SORs.

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Effect of a Single Dose of Deflazacort on Postoperative Pain, Swelling, and Trismus after Impacted Lower Third Molar Surgery: Randomised Clinical Trial

Kaplan,

Ciğerim,

Feslihan

et al. 2024

Medicina

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Background and Objectives: The aim of this study was to investigate the efficacy of a single preoperative dose of deflazacort on pain, swelling, and trismus after impacted lower third molar surgery. Materials and Methods: This randomised, prospective, double-blind, split-mouth clinical study included 26 healthy individuals with bilaterally impacted lower third molars. Group 1 was given a placebo (single-dose vitamin C tablet), and group 2 was given a single 30 mg dose of deflazacort 1 h prior to surgery. Pain was evaluated using the visual analogue scale for 1 week postoperatively. Oedema (in mm) and trismus (in mm) were evaluated preoperatively and on postoperative days 2 and 7. The Mann–Whitney U test was applied for group analyses. p values < 0.05 were considered statistically significant. Results: Postoperative pain scores were significantly lower in the deflazacort group at the 6th and 12th hours after surgery (p < 0.05). There were no significant differences in trismus between the groups at any time point (p > 0.05). There was less oedema in the deflazacort group on postoperative days 2 and 7, without any statistically significant difference (p > 0.05). Conclusions: A single preoperative dose of 30 mg deflazacort was found to be clinically effective in reducing pain and oedema after extraction of impacted lower third molars.

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Evaluation of the efficacy of topical rifamycin application on postoperative complications after lower impacted wisdom teeth surgery

Cited by 3 publications

References 28 publications

Effect of a Single Dose of Deflazacort on Postoperative Pain, Swelling and Trismus after Impacted Lower Third Molar Surgery

Effect of a Single Dose of Deflazacort on Postoperative Pain, Swelling and Trismus after Impacted Lower Third Molar Surgery

Selective Outcome Reporting Concerning Antibiotics and Third Molar Surgery

Effect of a Single Dose of Deflazacort on Postoperative Pain, Swelling, and Trismus after Impacted Lower Third Molar Surgery: Randomised Clinical Trial

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