Oral submucous fibrosis (OSMF) is one of the most common precancerous conditions of the oral mucosa involving any part of the oral cavity resulting in tissue scarring, dysphagia, and trismus. Habits of chewing areca nut, tobacco, and pan masala and smoking have revealed a strong association with the occurrence of OSMF. Due to its high morbidity and high malignant transformation rate (MTR), continuous efforts have been made to develop effective treatment options. Based on the stage of the disease, various treatment modalities such as medical and surgical therapies are available, each with its own set of advantages and disadvantages. Photobiomodulation (PBM) is an emerging minimally invasive therapy that can be utilized to treat OSMF through its anti-inflammatory and analgesic effects. With the advent of dual-wavelength diode lasers, the current case report focuses on a novel treatment strategy for managing OSMF in combination with pharmacological and oral physiotherapy to achieve optimal results.