Evaluation of the efficacy of pre-operative oral pregabalin in attenuating haemodynamic response to laryngoscopy and intubation and on post-operative pain in patients undergoing elective surgery under general anaesthesia

Chakraborty, Ritwik; Jain, Ragi; Sharma, Rashmi

doi:10.5958/2394-4994.2016.00071.8

Cited by 3 publications

(3 citation statements)

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“…Table 11 shows intergroup comparison of changes in MAP across time periods among the groups and found a statistically significant difference in MAP value between the groups. This is in consistent to the study done by Chakraborty et al .,[33] who concluded that premedication with 150 mg of oral pregabalin safely attenuates hemodynamic response to laryngoscopy and intubation. Sundar et al .…”

Section: Discussionsupporting

confidence: 92%

Oral pregabalin as premedication on anxiolysis and stress response to laryngoscopy and endotracheal intubation in patients undergoing laparoscopic cholecystectomy: A randomized double-blind study

et al. 2019

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Background: Direct laryngoscopy and tracheal intubation lead to increase in heart rate and blood pressure. This can cause serious complications in patients with coronary artery disease, reactive airways, or intracranial neuropathology. Preoperative anxiety is associated with greater level of postoperative pain. Attenuation of anxiety and hemodynamic response to laryngoscopy and intubation are cornerstone of better anesthetic outcome. Gabapentinoids (gabapentin and pregabalin) have been known to possess anxiolytic, analgesic, and anticonvulsant properties. Aim: The aim of this study is to determine the effects of oral pregabalin on anxiolysis and attenuation of stress response to laryngoscopy and endotracheal intubation. Study Design: This was a prospective randomized double-blind placebo controlled study. Materials and Methods: A total of 60 patients ASA physical status Class I and II, undergoing elective laparoscopic cholecystectomy, were randomly allocated into two groups receiving either oral placebo or oral pregabalin 150 mg, 60 min before induction of anesthesia. Visual analog scale (VAS) for anxiety was recorded before, and 60 min after giving the drug. Hemodynamic parameters (heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure) were recorded before, and 60 min after giving drug, during and 2, 4, 6, 8, and 10 min after intubation. Results: During preinduction, pregabalin showed a decrease in VAS and attenuation of stress response to laryngoscopy and intubation compared to that of placebo. The premedicated patients were hemodynamically stable perioperatively without side effects. Conclusion: Pregabalin is effective in attenuating preoperative anxiety and stress response to endotracheal intubation.

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Section: Discussionsupporting

confidence: 92%

Oral pregabalin as premedication on anxiolysis and stress response to laryngoscopy and endotracheal intubation in patients undergoing laparoscopic cholecystectomy: A randomized double-blind study

et al. 2019

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“…7 Similar study was done by Chakraborthy R et al, and Chaudhary A et al, where both the groups did a study between pregabalin and clonidine and inferred that pregabalin reduced the blood pressure but did not reduce the heart rate and clonidine reduced the heart rate effectively. 8,9 In our study Pregabalin group had a decrease in the SBP and DBP and the p value was significant <0.001. In our study, pregabalin better attenuated the SBP and DBP at serial intervals soon after intubation when compared to the clonidine group.…”

Section: Discussionsupporting

confidence: 47%

Efficacy of pregabalin premedication prior to surgery in attenuating the adverse hemodynamic response to laryngoscopy and tracheal intubation

Reddy¹,

Murari

2019

Int J Adv Med

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Background: In general pregabalin is used in patients with normal blood pressure undergoing operation for controlling the response of the pressor in nature. There are few studies which have been carried out to study efficacy of pregabalin in controlling responses to instrumentation of the airway in patients with controlled hypertension. Objective was to study efficacy of pregabalin premedication 90min prior to surgery in attenuating the adverse hemodynamic response to laryngoscopy and tracheal intubation.Methods: Hospital based randomized comparative trial was conducted. 100 patients of ASA I and II physical status aged 18-60 yrs scheduled to undergo elective surgery like orthopaedic, spine, otorhinolaryngeal, gynaecological and general surgical procedures. Patients were randomly divided into 2 groups of 50 each. Randomization was done by computer generated table. Group "P" received- 150mg pregabalin. Group "C" received-200µg clonidine.Results: The patients in clonidine group documented the heart rate as more compared to the patients in the pregabalin group at various time intervals. The patients in clonidine group documented the mean systolic blood pressure as more compared to the patients in the pregabalin group at various time intervals. The patients in clonidine group documented the mean diastolic blood pressure as more compared to the patients in the pregabalin group at various time intervals.Conclusions: We concluded that use of pregabalin is more effective in comparison to use of clonidine in terms of controlling the hemodynamic parameters. But it has been found that bradycardia may not be properly attenuated with the use of pregabalin.

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“…Eren et al [15] showed that 50 patients who underwent elective lumbar microdiscectomy surgery and received pregabalin had lower mean arterial pressure and heart rate values, and lower postintubation tachycardia and hypertension. Chakraborty [16] and Sundar [17] conducted research on pregabalin at different times and obtained similar results for 150 mg. Saxena et al [18] compared 150 and 300 mg doses of pregabalin, and reported no difference in laryngoscopy and intraoperative haemodynamic parameters between the 2 groups. Reuben et al [19] divided patients scheduled for lumbar laminectomy into 4 groups; 1) placebo, 2) 400 mg celecoxib, (3) 150 mg pregabalin, and 4) 150 mg pregabalin + 400 mg celecoxib one hour before and 12 hours after surgery.…”

Section: Discussionmentioning

confidence: 80%

Evaluation of the safety and effects of pregabalin premedication on sleep quality, haemodynamic changes and pain in elderly patients with comorbidities undergoing spinal stenosis

Kılıç

2020

J Pre Clin Clin Res.

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Evaluation of the efficacy of pre-operative oral pregabalin in attenuating haemodynamic response to laryngoscopy and intubation and on post-operative pain in patients undergoing elective surgery under general anaesthesia

Cited by 3 publications

References 0 publications

Oral pregabalin as premedication on anxiolysis and stress response to laryngoscopy and endotracheal intubation in patients undergoing laparoscopic cholecystectomy: A randomized double-blind study

Oral pregabalin as premedication on anxiolysis and stress response to laryngoscopy and endotracheal intubation in patients undergoing laparoscopic cholecystectomy: A randomized double-blind study

Efficacy of pregabalin premedication prior to surgery in attenuating the adverse hemodynamic response to laryngoscopy and tracheal intubation

Evaluation of the safety and effects of pregabalin premedication on sleep quality, haemodynamic changes and pain in elderly patients with comorbidities undergoing spinal stenosis

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