Evaluation of the Efficacy of Topical Timolol Therapy on Oral Lichen Planus: Clinical and Immunohistochemical Study

Metwaly, Hamdy; Ebrahem, Mohamed; Hussein, Fatma

doi:10.9734/jammr/2017/37603

Cited by 2 publications

(1 citation statement)

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“…(12) In addition, systemic corticosteroids are administered at larger dosages in severe instances, that may have adverse reactions, particularly if taken for an extended periods. (13) In the current investigation, patients with OLP who received topical propolis, MMF, or corticosteroids noticed substantial improvements in all clinical results. Throughout a two-month study period, 5% propolis, 2% MMF, and 0.1% triamcinolone acetonide treatment reduced pain, decreased erosions, and ulcerations, and enhanced the patient's quality of life.…”

Section: Discussionmentioning

confidence: 48%

Evaluation of the Efficacy of Topical Propolis versus Mucoadhesive Mycophenolate Mofetil (MMF) in the Management of Symptomatic Oral Lichen Planus

gamal,

Sabry,

yousef

2024

Egyptian Dental Journal

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Aim: To assess the potential impacts of propolis and mucoadhesive mycophenolate mofetil (MMF) on oral lichen planus. Methodology:The research was performed on 30 individuals suffering from atrophic-erosive oral lichen-planus. And they were allocated into three groups; Group Ӏ: were managed with propolis 5% gel, Group ӀӀ: were managed with Mycophenolate mofetil (MMF) 2% mucoadhesive and Group ӀӀӀ (control group): were managed with triamcinolone acetonide 0.1%. The clinical progress was evaluated utilizing the Visual Analog Scale (VAS) for pain intensity and MOMI scale. The clinical parameters were recorded at the baseline and then every two weeks for two months.Results: A substantial enhancement existed in all clinical results throughout the follow-up period when compared to the baseline (P < 0.05). There was non-significant variation among the among the groups at the end of the eight's week regarding VAS and MOMI scale (P > 0.05). Conclusions:Propolis and MMF might be utilized as alternative treatment for the management of oral lichen-planus.

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Section: Discussionmentioning

confidence: 48%

Evaluation of the Efficacy of Topical Propolis versus Mucoadhesive Mycophenolate Mofetil (MMF) in the Management of Symptomatic Oral Lichen Planus

gamal,

Sabry,

yousef

2024

Egyptian Dental Journal

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Stress-induced Oral Lichen Planus Immunopathogenesis and Potential Therapy: A Narrative Review

Basalamah

Pramitha²,

Pasaribu³

et al. 2022

IJDM

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Background: Oral lichen planus is a chronic inflammatory condition that only involves in the oral cavity and is mediated by the cellular immune system. The etiology of OLP is unclear but autoreactive T lymphocytes are considered to play an important role in the development of OLP. Factors like stress and psychological anxiety have been associated with OLP but their roles in the development of OLP is yet explored. Purpose: To describe stress-induced OLP immunopathogenesis and therapeutic potential. Reviews: In the early stages, the mechanism of OLP involves the expression of keratinocyte antigens or exposure to an antigen in the form of self-peptide or heat shock protein (HSP). HSP90 is the most expressed heat shock protein in the basal layer of keratinocytes and plays a role in recruitment of cellular immune cells through the production of cytokines due to TLR2/4 and CD91 activation, inflammatory cell migration due to 4 integrin activation, and increased antigen presentation due to HSP90-peptide binding to MHC class I/II. Stress as a physiological response triggers the release of the hormone cortisol from the adrenal cortex and catecholamine hormones such as epinephrine/ adrenaline and norepinephrine/noradrenaline from the adrenal medulla. Catecholamines increase the migration of T lymphocyte cells through the interaction of integrins and integrin ligands on the endothelium through the expression of 2-integrin after binding to adrenergic receptors on the cell membrane. Conclusion: Oral lichen planus is a chronic inflammatory condition caused by various factors where stress increases the migration of T lymphocyte cells on the side that expresses self-peptides and antigens through the interaction of immune cells with catecholamines. Topical nonselective beta blockers can be supporting therapy in reducing pain and size of OLP lesions.

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Evaluation of the Efficacy of Topical Timolol Therapy on Oral Lichen Planus: Clinical and Immunohistochemical Study

Cited by 2 publications

References 0 publications

Evaluation of the Efficacy of Topical Propolis versus Mucoadhesive Mycophenolate Mofetil (MMF) in the Management of Symptomatic Oral Lichen Planus

Evaluation of the Efficacy of Topical Propolis versus Mucoadhesive Mycophenolate Mofetil (MMF) in the Management of Symptomatic Oral Lichen Planus

Stress-induced Oral Lichen Planus Immunopathogenesis and Potential Therapy: A Narrative Review

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