Evaluation of the Electrocardiographic Parameters of Anemic Children Before and After Anemia Correction

Uğurlu, Mehmet; Temel, Münevver Tuğba

doi:10.5152/cjms.2020.1390

Cited by 1 publication

(5 citation statements)

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“…Population-based studies demonstrate that disease activity in IBD is associated with an increased risk of morbidity and mortality due to CVD [16][17][18][19][20][21][22][23][24][25]. Furthermore, a number of observations indicate that patients with IBD are at a higher risk of developing ECG abnormalities, i.e., QTc interval [21,[26][27][28][29][30][31][32][33]. QTc interval represents the most investigated ECG parameter in patients with IBD [27][28][29][30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, a number of observations indicate that patients with IBD are at a higher risk of developing ECG abnormalities, i.e., QTc interval [21,[26][27][28][29][30][31][32][33]. QTc interval represents the most investigated ECG parameter in patients with IBD [27][28][29][30][31][32][33]. Studies identified by our systematic review are not homogeneous with respect to the design and the characteristics of the patients.…”

Section: Discussionmentioning

confidence: 99%

“…Studies identified by our systematic review are not homogeneous with respect to the design and the characteristics of the patients. Most of them indicate that patients with IBD are at a higher risk of developing QTc interval prolongation [27,[29][30][31]33]. Two studies did not find differences in QTc values between IBD patients and controls [28,32].…”

Section: Discussionmentioning

confidence: 99%

“…Figure 4 shows the PRISMA diagram summarizing the sequence of the literature selection. Seven studies reported on QTc interval [27][28][29][30][31][32][33]. Table 3 There were no significant relationships between the QTc values and all the other baseline characteristics, i.e., gender, age, disease duration, type of IBD (UC or CD), and therapy.…”

Section: Systematic Reviewmentioning

confidence: 99%

“…Notably, morbidity and mortality due to CVD are exclusively observed during active IBD flares. Studies based on electrocardiogram (ECG) findings indicate that patients with IBD are at a higher risk of developing QT interval abnormalities, in particular heart-rate-corrected QT interval (QTc) [26][27][28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

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Association between Corrected QT Interval and C-Reactive Protein in Patients with Inflammatory Bowel Diseases

et al. 2020

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Background and objectives: Electrocardiograph abnormalities (i.e., QT interval prolongation) have been described in inflammatory bowel diseases (IBD). We aimed to measure the QT interval in a cohort of patients with IBD and to analyze its relationship with clinical and inflammatory activity. Materials and Methods: We performed a cross-sectional study that included 38 IBD outpatients and 38 “age- and sex-matched” healthy controls. Nine patients had active IBD, and 29 were in clinical remission. Among the latter, 10 patients had sustained (lasting >1 year) and 19 had short-term remission (≤1 year). Corrected QT (QTc) interval was measured on standard 12-lead electrocardiograph. A systematic review of the literature on studies investigating the QT interval in patients with IBD was also performed. Results: QTc interval values were similar between IBD patients and healthy controls (417.58 ± 22.05 ms vs. 409.13 ± 19.61 ms, respectively; p: 0.479). Patients with active IBD had significantly higher QTc values (435.11 ± 27.31 ms) than both controls (409.13 ± 19.61 ms) and patients in remission (412.14 ± 17.33 ms) (p: 0.031). Post hoc analysis showed that the difference in QTc values between active IBD and remission was attributable to the group of patients with sustained remission (p < 0.05). Lastly, a significant correlation between QTc interval and C-reactive protein (CRP) values was observed (Spearman test: r = 0.563; p: 0.0005). Conclusions: Our study demonstrates an association between QTc duration and both clinical and inflammatory activity in patients with IBD. The higher the CRP value, the longer is the QTc duration. For practical purposes, all patients with active IBD should undergo a standard ECG. Prescription of drugs able to modify the QT interval should be avoided in patients with active IBD. The systematic review of the literature indicated that this is the first published study demonstrating an association between the QTc duration and CRP values in patients with IBD.

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