Evaluation of the erythropoietic and anti-sickling properties of Ficus capensis leaf extract in the treatment of anaemia

Umeokoli, BO; Onyegbule, FA; Gugu, Thaddeus Harrison; Igboeme, SO

doi:10.1055/s-0033-1352048

Cited by 8 publications

(9 citation statements)

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“…Also, the latex from the stem is used in treating cuts and wounds whereas the latex from roots is used in the treatment of mumps, diarrhea, and vomiting (Devkota and Karmacharya, 2003). also it has a blood-boosting effect (Otitoju et al, 2014;Njoku-oji et al, 2016), anti-sickling (Umeokoli et al, 2013;Mpiana et al, 2008) antibacterial (Oyeleke et al, 2008), antiabortifacient (Owolabi et al, 2009), immunestimulatory (Daikwo et al, 2012), antidiarrhoea (Owolabi, 2013;Manandhar, 1991), antioxidant (Ramde-Tiendrebeogo et al, 2012) and pro-fertility in treating azoospermia (Gelfand et al,1985;Akomolafe et al, 2016). Bark and root show hypoglycaemic and anthelmintic activity (Mazumder et al, 2009;Ghosh et al, 2004).…”

Section: Ficus Roxburghii (Timal)mentioning

confidence: 99%

The Difference of Solvent Polarity to Qualitative and Quantitative Phytochemical Contents and Antioxidant Activity of Ficus roxburghii Wall. Leaves and Fruits Extracts

Ruwali¹,

Pateliya²

2019

Int.J.Curr.Microbiol.App.Sci

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The aim of this work was to establish the antioxidant capacity and the polyphenolic profile of important medicinal plant, Ficus roxburghii Wall. that could potentially be used in the human and animal diet. The widespread use of herbal remedies and healthcare preparations is described in the Vedas and the Bible. Medicinal Plants have been used for thousands of years to flavor and conserve food, to treat health disorders and to prevent diseases including epidemics. Active compounds produced during secondary metabolism are usually responsible for the biological properties of plant species used throughout the globe for various purposes, including treatment of infectious diseases. One such medicinally important plant Ficus roxburghii was chosen and the present study was designed to perform preliminary phytochemical analysis of various extracts of Ficus roxburghii leaves and fruits viz. methanolic (FRME), ethanolic (FRETH), chloroform (FRCHLO), hexane (FRHEX). In addition, total phenolic (TPC) and flavonoid (TFC) contents of various extracts were measured, also the various extracts were evaluated for the antioxidant capacities using most widely accepted in vitro chemical tests such as DPPH and ABTS free radical scavenging assays. The result of the preliminary phytochemical analysis revealed the presence of various phytochemical groups viz. carbohydrates, reducing sugar, tannins, phenolics, flavonoids, lignins, amino acids, saponins, glycosides, sterols, triterpenes, and alkaloids with variations among the various extracts. Results for the assays of antioxidative activity showed that all extracts exhibited significant antioxidant activities in a dose-dependent manner. The best antioxidant potential was found in Methanolic extract of F. roxburghii (FRME). FRME has the ability of scavenging ABTS and DPPH radicals in dose-dependent manner, to much better extent than FRCHLO, FRHEX and FRETH. This study shows that the fruit and leaf extract of Ficus roxburghii could be used as a probable antioxidative agent. The leaves of Ficus roxburghii show a more positive result in the antioxidant and phytochemical test as compared to fruits. Additional highly developed research is essential for isolation and identification of specific active components which are responsible for pharmacological properties of the plant.

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Section: Ficus Roxburghii (Timal)mentioning

confidence: 99%

The Difference of Solvent Polarity to Qualitative and Quantitative Phytochemical Contents and Antioxidant Activity of Ficus roxburghii Wall. Leaves and Fruits Extracts

Ruwali¹,

Pateliya²

2019

Int.J.Curr.Microbiol.App.Sci

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“…It is also used to treat circumcision wounds, leprosy and epilepsy, rickets, infertility, gonorrhoea, oedema and respiratory disorders [4]. In addition to its traditional uses, scientific research has reported its; blood-boosting effect [15], anti-sickling [16,17] antibacterial [18], anti-abortifacient, antidiarrhoea [19], immune-stimulatory [20],…”

Section: Introductionmentioning

confidence: 99%

DETERMINATION OF THE PHYTOCHEMICALS, MINERALS, PROXIMATE AND ANTIBACTERIAL CONSTITUENTS OF THE LEAF, STEM, ROOT AND SEED OF Ficus capensis (BUSH FIG)

Mgbemena¹,

Akoh²,

Obodo³

et al. 2022

JCSN

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The leaf extract of Ficus capensis is used in some part of Nigeria as blood booster, this motivates the researchers on the need to assess the phytochemical, proximate, mineral and antibacterial compositions of the leaf, seed, stem and root of the plant. The various parts of Ficus capensis were got from a farm land in Umuahia and analysed for phytochemicals, proximate, mineral and antibacterial contents using their various methods of analysis. Qualitative phytochemical analysis revealed the presence of all the phytochemicals analysed in all parts of the plant while quantitative phytochemical analysis indicated phenol as the lowest phytochemical in the order: stem 0.28 ± 0.02 < root 0.32 ± 0.00 < leaf 0.35 ± 0.01< seed 0.43± 0.02 and tannin as the highest in the order: root < stem< seed < leave. The results of mineral analysis revealed potassium as the highest followed by calcium followed by sodium, magnesium, zinc and iron in the order: stem < root < seed < leaf. The result of proximate analysis Showed carbohydrate as the highest followed by ash in the order: root 12.45 ± 0.00 < leaf 17.45 ± 0.05 < stem 18,24 ± 0.02 < seed 18.35 ± 0.01 while the antibacterial analysis against E. coli., K. pneumonia, and Salmonella typhi showed good efficiency in 200 mg/ml with greater inhibition compared to 100mg/ml. Ficus capensis leaf, stem, root and seed contained good amounts of minerals, phytochemicals, proximate and also showed good efficiency for antibacterial inhibition. It is therefore recommended and encouraged for consumption.

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“…Ficus capensis is locally called Uwaryara (Hausa), Akokoro (Igbo), Opoto (Yoruba), Obada (Edo), and Rima bichehi (Fulani). In Nigeria, this plant is widely used to prepare traditional medicine that has an anti-bacterial (15), anti-sickling (16), anti-abortifacient (17), immune-stimulatory (18), and anti-diarrhoea (19) activities. The leaves of F. capensis have been used as an antioxidant and pro-fertility to treat azoospermia (20,21).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of an ethanolic leaf extract from Ficus capensis against Phenylhydrazine induced anaemia in Wistar rats

Ibe

Akuodor

Elom

et al. 2022

J Herbmed Pharmacol

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Introduction: Ficus capensis has been used in traditional medicine to treat anaemia, tuberculosis, convulsion, pains, wounds, respiratory disorders, and other health challenges. This study investigated the effect of F. capensis ethanolic leaf extract in phenylhydrazine (PHZ)-induced anaemia in Wistar rats. Methods: Induction of anaemia was done by intraperitoneal administration of PHZ (40 mg/kg for 48 hours). A normal group and an anaemic group were treated daily with a single dose of 20 mL/kg of distilled water and considered as control and anaemic (non-treated) groups. Then, the remaining groups were treated with 100, 200, and 400 mg/kg of ethanol extract of F. capensis leaves for 21 days, respectively. Blood samples from the rats were run in three batches of baseline, post anaemia induction, and post-treatment. Phytochemical screening and acute toxicity tests of the extract were also carried out following standard procedures. Results: The results showed a consistent significant increase in haematological parameters among various experimental groups. Haemoglobin (Hb), red blood cell (RBC) count, mean corpuscular volume (MCV), packed cell volume (PCV), mean cell haemoglobin (MCH) and Mean cell haemoglobin concentration (MCHC) values of treated rats were significantly increased compared to the anaemic control. The secondary metabolites of leaf extract were alkaloids, saponins, tannins, steroids, flavonoids, phenols, and reducing sugar, while the acute toxicity test was found to be non-toxic at 5000 mg/kg in rats. Conclusion: The ethanol leaf extract of F. capensis might provide an alternative cure for anaemia and boosts blood count.

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Evaluation of the erythropoietic and anti-sickling properties of Ficus capensis leaf extract in the treatment of anaemia

Cited by 8 publications

References 0 publications

The Difference of Solvent Polarity to Qualitative and Quantitative Phytochemical Contents and Antioxidant Activity of Ficus roxburghii Wall. Leaves and Fruits Extracts

The Difference of Solvent Polarity to Qualitative and Quantitative Phytochemical Contents and Antioxidant Activity of Ficus roxburghii Wall. Leaves and Fruits Extracts

DETERMINATION OF THE PHYTOCHEMICALS, MINERALS, PROXIMATE AND ANTIBACTERIAL CONSTITUENTS OF THE LEAF, STEM, ROOT AND SEED OF Ficus capensis (BUSH FIG)

Protective effects of an ethanolic leaf extract from Ficus capensis against Phenylhydrazine induced anaemia in Wistar rats

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