Evaluation of the Factors Affecting Survival in Patients with Gastric Cancer According to the 8th Edition of the Tumor, Node and Metastasis Classification

Abstract

We aimed to evaluate the effect of different parameters on survival in patients with gastric adenocarcinoma who underwent D2 lymph node dissection with more than 15 lymph nodes. Methods: A total of 161 patients with gastric adenocarcinoma, who underwent curative gastrectomy and had more than 15 lymph nodes dissected between January 2001 and January 2015, were retrospectively evaluated. A hundred and forty-six patients were included in the study. Results: The mean follow-up period was 24 (12-102) months and the mean survival time was 818.80±692.42 (66-3065) days. Gender, age, lymphovascular invasion and perineural invasion, tumor differentiation and histology were not found to have a statistically significant effect on overall survival. Length of hospital stay, tumor location, extent of surgery, chemotherapy, tumor stage (T category), total number of harvested lymph nodes, number of metastatic lymph nodes, lymph node status (N status), percentage of lymph node positivity, metastatic lymph node ratio and stage were found to have a statistically significant effect on overall survival. Conclusion: Having distally located tumor, having chemotherapy, higher total number of harvested lymph node and lower N category were better prognostic factor for overall survival in gastric cancer patients having curative resection with more than 15 lymph nodes harvested.

Prognostic value of preoperative glucose to lymphocytes ratio in patients with resected gastric cancer

“…One of the important factors determining the overall survival of gastric cancer is the number of metastatic lymph nodes [23][24][25][26]. In this study, while NLR and GLR were significantly related to the number of metastatic lymph nodes, CAR was not.…”

Evaluation of HER2 overexpression, clinicopathological characteristics, and factors affecting survival in gastric cancer

“…[ 12 , 14 , 16 ] There are also studies reporting that there is no relationship between perineural invasion and survival. [ 13 , 15 ] In this study, we found that the survival rate was lower in gastric cancer patients with perineural invasion as a result of univariate analysis.…”

“…[10] Survival rates have also been demonstrated to be lower in those with lymphovascular invasion in the previous studies. [11][12][13][14] However, Berkeşoğlu et al [15] reported that there was no relationship between lymphovascular invasion and survival. In our study, similarly, there was no difference between patients with and without lymphovascular invasion in terms of survival rate.…”

“…[11][12][13]14,17,[21][22][23][24] There are also studies reporting that the stage could not be found as an independent prognostic factor affecting survival rate. [15,19] The poor prognosis in the advanced stage shows the importance of diagnosis and treatment at earlier stages.…”