Evaluation of the factors influencing the resultant diameter of the electrospun gelatin/sodium alginate nanofibers via Box–Behnken design

Gönen, Seza Özge; Taygun, Melek Erol; Küçükbayrak, Sadriye

doi:10.1016/j.msec.2015.09.024

Cited by 36 publications

(19 citation statements)

References 58 publications

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“…The concentration of the mixed solution is a key factor in the electrospinning process probably because of the increase in conductivity of the solution and the surface charge density of the solution jet. In contrast, fiber diameter increased with concentration, which is consistent with the results from other studies . Meanwhile, the exponent n value of non‐Newtonian fluid with different PEG content can be calculated according to the power formula, as shown in Table .…”

Section: Resultssupporting

confidence: 88%

Optimization of biodegradable PEG/PLGA nanofiber mats electrospinning process for anti‐adhesion application

Zhao

Zhu

Zhang³

et al. 2018

J of Applied Polymer Sci

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Electrospinning is a direct, continuous, and useful technique to prepare nanofiber by applying electrostatic forces. In this study, poly(lactic‐co‐glycolic acid)/poly(ethylene glycol) (PLGA/PEG) nanofiber mats were prepared, and electrospinning process was optimized to obtain appropriate fiber diameter and hydrophilicity for anti‐adhesion application. Optimization of applied voltage, PEG content, and feeding rate was investigated using response surface methodology. A total of 15 trials were designed to optimize the parameters. Fiber diameter was measured using scanning electron microscopy. Individual and interactive effects of the solution properties were determined. Moreover, the adequacy of the models was verified by validation experiments. For anti‐adhesion test, a nanofiber mat was produced based on the suggested optimum electrospinning conditions. Results showed that optimum fiber diameters were obtained using 7.5% PEG content, applied voltage of 19 kV, and flow rate of 3 mL/h. Experimental results were in good agreement with the predicted fiber diameters. Furthermore, a rat model of sidewall defect‐cecum abrasion was employed to investigate the efficacy of PEG/PLGA in preventing postoperative peritoneal adhesions. Hence, this study provides an overview on the fabrication of PLGA/PEG nanofibers with targeted diameter, which may be used in anti‐adhesion. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46282.

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Section: Resultssupporting

confidence: 88%

Optimization of biodegradable PEG/PLGA nanofiber mats electrospinning process for anti‐adhesion application

Zhao

Zhu

Zhang³

et al. 2018

J of Applied Polymer Sci

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“…Response surface methodology (RSM) is the most popular method used to model and optimize electrospun nanofibers in recent years . In this work, three main factors of electrospinning (i.e., solution concentration, applied voltage, and tip to collector distance) were investigated to find out the effects of processing parameters on the morphology and membrane structure of electrospun SPEEK nanofibers collected at the constant take‐up speed of 7 m/s.…”

Section: Resultsmentioning

confidence: 99%

Modeling and optimization of sulfonated poly (ether ether ketone) nanofibrous proton exchange membranes with response surface methodology

Sadrjahani

Gharehaghaji

Javanbakht

2017

Polymer Engineering & Sci

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The morphological control of proton conductive nanofibrous mat used in proton exchange membranes (PEMs) is a key issue to improve proton conductivity of PEMs. In this study, response surface methodology (RSM) was utilized to investigate the morphological characterizations of electrospun sulfonated poly(ether ether ketone) (SPEEK) nanofibrous membranes. The effects of electrospinning parameters namely solution concentration, applied voltage and tip to collector distance were studied on the average diameter, its standard deviation and the degree of alignment of SPEEK nanofibers. The adequacy of the response surface models was verified by the validation experiments. Optimized conditions were obtained to meet the desired status of collecting more uniform and finer nanofibers with improved alignment. After obtaining the significant factors and optimal test level, an additional optimization was conducted at different take-up speeds to fabricate high-grade aligned nanofibers. The resultant nanofibers had the diameter of 107 6 22 nm at the optimum point which was in good agreement with the predicted response values. The highest degree of alignment was yielded at the take-up speed of 8.8 m/s with the maximum second-order orientation parameter of 0.869. Electrochemical spectroscopy analysis showed that the aligning of proton conductive nanofibers improved inplane proton conductivity about 67%. POLYM. ENG. SCI., 58:619-631,

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“…Resulting from their unique properties, such as their easy moldability, light weight, and relative inexpensiveness, polymeric materials play a significant role in our daily lives [1][2][3][4]. They have been employed in different fields, including drug delivery, catalysis, healthcare, and construction; hence, it is not possible to picture life without them.…”

Section: Introductionmentioning

confidence: 99%

“…They have been employed in different fields, including drug delivery, catalysis, healthcare, and construction; hence, it is not possible to picture life without them. There is a welcome paradigm shift toward the use of polymeric materials that hold "green credentials", regarding their distinctive properties, such as biodegradability, biocompatibility, renewability, and abundant availability [3,4]. The driving forces behind are associated with the rate at which our oil reserves are being depleted as well as the importance of reducing our carbon footprint.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Alginate Nanofibers Toward Various Applications: A Review

et al. 2020

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Alginate has been a material of choice for a spectrum of applications, ranging from metal adsorption to wound dressing. Electrospinning has added a new dimension to polymeric materials, including alginate, which can be processed to their nanosize levels in order to afford unique nanostructured materials with fascinating properties. The resulting nanostructured materials often feature high porosity, stability, permeability, and a large surface-to-volume ratio. In the present review, recent trends on electrospun alginate nanofibers from over the past 10 years toward advanced applications are discussed. The application of electrospun alginate nanofibers in various fields such as bioremediation, scaffolds for skin tissue engineering, drug delivery, and sensors are also elucidated.

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Evaluation of the factors influencing the resultant diameter of the electrospun gelatin/sodium alginate nanofibers via Box–Behnken design

Cited by 36 publications

References 58 publications

Optimization of biodegradable PEG/PLGA nanofiber mats electrospinning process for anti‐adhesion application

Optimization of biodegradable PEG/PLGA nanofiber mats electrospinning process for anti‐adhesion application

Modeling and optimization of sulfonated poly (ether ether ketone) nanofibrous proton exchange membranes with response surface methodology

Electrospun Alginate Nanofibers Toward Various Applications: A Review

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