Evaluation of the ganglion cell layer thickness in children with attention deficit hyperactivity disorder and comorbid oppositional defiant disorder (eng)

Abstract

Evaluation of the ganglion cell layer thickness in children with attention deficit hyperactivity disorder and comorbid oppositional defiant disorder Gangliyon hücre tabakasý kalýnlýðýnýn dikkat eksikliði hiperaktivite bozukluðu ve komorbid karþýt olma karþý gelme bozukluðu olan çocuklarda deðerlendirilmesi

Assessment of intraocular pressure, macular thickness, retinal nerve fiber layer, and ganglion cell layer thicknesses: ocular parameters and optical coherence tomography findings in attention-deficit/hyperactivity disorder

“…5 In another study, Bodur et al compared RNFL thickness, ganglion cell layer (GCL), and optic nerve thickness in patients with ADHD, ADHD plus oppositional defiant disorder (ODD), and controls. 15 The authors found no difference in RNFL thickness between the groups, but significantly lower GCL and optic nerve thickness in the patient groups than in controls. 15 The abovementioned studies examining the relationship between OCT and ADHD only included ADHD and control groups; to date, no studies have compared drugtreated ADHD patients, drug-naive ADHD patients, and healthy controls.…”

“…10,11 For centuries, the retina has been known to provide insight into the status of the brain, suggesting the suitability of retinal research to explore bipolar disorder, schizophrenia, major depressive disorder, and ADHD. 5,[12][13][14][15] Optical coherence tomography (OCT) is a comparatively new, noninvasive, and contactless imaging technique that was first used in the field of ophthalmology. 16 The use of OCT to study axonal structural abnormalities has increased in recent years.…”

“…Notably, OCT has been used in a few studies to evaluate patients with ADHD. 2,5,15 Hergüner et al investigated macular thickness, macular volume, and RNFL thickness in children with ADHD and a control group. 5 They found lower RNFL thickness only in the nasal quadrant in a patient with ADHD compared to the control group; in the other quadrants, RNFL thickness was not significantly different.…”

Retinal nerve fiber layer, macular thickness and anterior segment measurements in attention deficit and hyperactivity disorder

“…In parallel with the previous result, we found RNFL thickness was lower in the ADHD group than in the control group, but this difference was not statistically significant. In the other study, children and adolescents with ADHD and Oppositional Defiant Disorder (ODD) accompanying ADHD compared to healthy controls, no significant difference was found in terms of RNFL but the ganglion cell layer of the retina was found to be thinner in ADHD and ADHD + ODD groups [21].…”

“…Hergüner et al found that the ADHD group's macular thickness did not differ from age-matched controls, but the RNFL thickness is reduced in the ADHD group [20]. In another study, children and adolescents with ADHD and Oppositional Defiant Disorder (ODD) accompanying ADHD compared to healthy controls, no significant difference was found in terms of RNFL but the ganglion cell layer of the retina was found to be thinner in ADHD and ADHD + ODD groups [21].…”