Evaluation of the genotoxic and antigenotoxic potential of Melissa officinalis in mice

Carvalho, Natália C.; Corrêa-Angeloni, Maria Júlia Frydberg; Leffa, Daniela Dimer; Moreira, Jeverson; Nicolau, Vanessa; Amaral, Patrícia de Aguiar; Rossatto, Ângela Erna; Andrade, Vanessa Moraes de

doi:10.1590/s1415-47572011000200021

Cited by 39 publications

(30 citation statements)

References 42 publications

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“…Recently, De CarvalhoI et al, 47 have demonstrated that M. officinalis exhibits antigenotoxic/ antimutagenic properties in mice. So in our work the effect of melissa extract as a main source of antioxidants against malathion hazard in rat testes was studied and found that the M. officinalis extract has antioxidant activity agent and could improve the biochemical and histochemical picture of rat testes against toxicity of malathion.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

El-Raheem¹

2015

MOJT

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It has been confirmed that organophosphorus compounds OP altered glucose homeostasis. Considerable experimental and clinical evidences have contributed the beneficial effects of antioxidant compounds in plant extract on hepatorenal toxicity. The aim of this study was to evaluate whether Melissa officinalis extract, was able to ameliorative hepatorenal injury induced by organophosphorus Malathion. Malathion at 27mg/kg bw was administered to rats alone or in combination with Melissa officinalis extract at 200mg/kg bw. Malathion decreases feed intake and body weight as well as liver and kidneys weight. Moreover, Malathion increases the levels of various serum marker enzymes AST, ALT and ALP. A significant increase in the level of serum urea, uric acid and creatinine in response to ML treatment. As well as ML induced increase in MDA in liver and kidneys while induced decreases in the activities of SOD, GPx and CAT. Co-administration of malathion with Melissa officinalis extract resulted in restoration of all tested parameter. These results may be due to the significant increase recorded in acetylcholine esterase (Ach E) activity invivo after co administration of malathion and Melissa officinalis extract. In histological study of liver and kidney, Malathion induced damage in liver and kidneys. However, MO administration to ML-treated animals resulted in overall improvement in liver and kidneys damage, emphasizing its antioxidant role. In light of the available data, it can deduce that ML-induced lipid peroxidation, oxidative stress, liver and kidneys damage rats, and conjoint supplementation of MO has resulted in pronounced ameliorating effect in all tested parameter and histological picture of liver and kidney. MOJ Toxicology Research ArticleOpen Access Ameliorative role of melissa officinalis against hepatorenal toxicities of organophosphorus malathion in male rats 104Copyright: ©2015 Sief et al. Citation:Sief MM, Khalil FA, Abou-Arab AA, et al. Ameliorative role of melissa officinalis against hepatorenal toxicities of organophosphorus malathion in male rats.

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Section: Discussionmentioning

confidence: 99%

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

El-Raheem¹

2015

MOJT

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“…For cytotoxicity assays, the 50% inhibition concentration (IC 50 ), expressed as the concentration of sample that caused a 50% inhibition of enzyme activity in the cells, was applied. To calculate the IC 50 , the absorbance value of the blank was subtracted from the absorbance values of each sample, and the results were compared with the absorbance values of the solvent controls.…”

Section: Cytotoxicity Test (Mtt Test)mentioning

confidence: 99%

Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey

Asadi¹,

Nath²,

Özhan³

2015

Turk J Med Sci

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IntroductionSince ancient times, herbs have played an important role in the treatment of different diseases in many regions of world, largely for their expectorant, aphrodisiac, diuretic, diaphoretic, antispasmodic, stomachic, and sedative properties (1). The World Health Organization reported that 70%-80% of the global population relies on herbs for primary health care. In addition, because they are natural products, it is generally believed that herbs are essentially safe and free from side effects. Consequently, the consumption of nonprescription herbs has steadily increased over the past few decades (2).Despite the therapeutic advantages of herbs, reports have indicated the potential toxicity of some herbal components. Herbs contain a variety of chemical substances that act upon the body. In addition, the quality of herbs can be affected by toxic contaminants originating from industry, agriculture, and private households, including toxins that can cause mutagenic and carcinogenic effects from long-term and widespread use (3-6). Moreover, herbal medicines are generally a mixture of a number of herbs in a single preparation and contain several active ingredients that induce various pharmacological effects (7,8). To date, there are few scientific studies on the safety and potential toxicity of herbs, despite growing concerns over the lack of both scientific evidence and quality control data regarding the safety and efficacy of herbs (9,10).Sexual dysfunction is a condition that affects 15-30 million men worldwide, and it occurs in 10%-52% of men and 25%-63% of women (11,12). Many believe that sexual dysfunction is associated with the modern lifestyle. As a result, individuals turn to natural products, such as traditional herbs, that produce aphrodisiac effects for sexual enhancement. Aphrodisiac herbs are used to treat sexual dysfunction because they alter specific neurotransmitters or sex hormones. Specifically, herbs with aphrodisiac properties can induce vasodilatation that results in a sustained erection, and can cause irritation of genital mucosa that enhances sensory experience during coitus (13).Background/aim: Sexual dysfunction is a serious problem worldwide. In Turkey, herbal products are used by some people suffering from sexual dysfunction. Despite their therapeutic advantages, some constituents of herbs are potentially toxic and pose health risks because they can be bought from the market without a prescription. Therefore, we aimed to determine the safety of herbs possessing aphrodisiac effects, chosen on the basis of their frequency of medicinal use and commercial importance in Turkey. Materials and methods:Ten herbs (Anethum graveolens, Carthamus tinctorius, Citrus aurantium, Cocos nucifera, Glycyrrhiza glabra, Melissa officinalis, Nigella arvensis, Pinus pinea, Prunus mahaleb, and Zingiber officinale) were extracted with water, methanol, and chloroform. The cyto-and genotoxic potentials of the extracts were assessed using an MTT test on a rat kidney cell line and an Ames assay in Salmonella typhi...

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“…Medicinal plants are important antimutagenic and chemopreventive agents capable of preventing and/or repairing genomic changes (Malini et al, 2010;de Carvalho et al, 2011). It is estimated that 60% of anticancer drugs are derived directly or indirectly from medicinal plants ( WHO, 2011), which explains the large amount of research that aims to evaluate biological activities that demonstrate the balance and equilibrium of natural defenses through the action of antioxidants in modulating genomic repair (de Mesquita et al, 2009;Malini et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Antigenotoxic and antimutagenic effects of Schinus terebinthifolius Raddi in Allium cepa and Swiss mice: A comparative study

Fedel-Miyasato¹,

Formagio²,

Auharek³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. It is estimated that 60% of anticancer drugs are derived directly or indirectly from medicinal plants. Schinus terebinthifolius Raddi (Anacardiaceae) is traditionally used in Brazilian medicine to treat inflammation, ulcers, and tumors. Because of the need to identify new antimutagenic agents and to determine their mechanism of action, this study evaluated the chemopreventive activity of the methanolic extract from leaves of S. terebinthifolius (MEST) in Allium cepa cells and in Swiss mice analyzing different protocols of MEST in association with DNA-damaging agents. The antigenotoxic and antimutagenic aspects in peripheral blood were evaluated using the comet and micronucleus assays, respectively. The percentage of damage reduction was used to compare the A. cepa and mice results. Our results showed for the first time that MEST can act as a chemopreventive compound that promotes cellular genome integrity by desmutagenic and bioantimutagenic activities in vegetal and animal models. This finding may therefore have therapeutic applications that can indirectly correlate to the prevention and/or treatment of the degenerative diseases such as cancer.

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Evaluation of the genotoxic and antigenotoxic potential of Melissa officinalis in mice

Cited by 39 publications

References 42 publications

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

Ameliorative Role of Melissa officinalis against Hepatorenal Toxicities of Organophosphorus Malathion in Male Rats

Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey

Antigenotoxic and antimutagenic effects of Schinus terebinthifolius Raddi in Allium cepa and Swiss mice: A comparative study

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