Evaluation of the genotoxic, mutagenic and oxidant stress potentials of municipal solid waste incinerator bottom ash leachates

Radetski, Claudemir M.; Ferrari, B.; Cotelle, Sylvie; Masfaraud, Jean-François; Férard, Jean-François

doi:10.1016/j.scitotenv.2004.05.015

Cited by 62 publications

(32 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Li et al [54] and Bakare et al [55] reported that the possible mechanism of municipal landfill and sludge leachates induced genotoxicity and toxicity in mice was by oxidative damage. Similarly, oxidative stress was implicated in incinerated bottom ash and municipal landfill leachates induced toxicity and genotoxicity in plant test systems [56][57][58]. These are in concert with our findings that e-waste leachate and contaminated well water induced elevated levels of lipid peroxidation and alterations in oxidative stress enzymes in liver of treated mice.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

In Vivo Cytogenotoxicity and Oxidative Stress Induced by Electronic Waste Leachate and Contaminated Well Water

et al. 2013

View full text Add to dashboard Cite

Environmental, plant and animal exposure to hazardous substances from electronic wastes (e-wastes) in Nigeria is increasing. In this study, the potential cytogenotoxicity of e-wastes leachate and contaminated well water samples obtained from Alaba International Electronic Market in Lagos, Nigeria, using induction of chromosome and root growth anomalies in Allium cepa, and micronucleus (MN) in peripheral erythrocytes of Clarias gariepinus, was evaluated. The possible cause of DNA damage via the assessments of liver malondialdehyde (MDA), catalase (CAT), reduced glutathione (GSH) and superoxide dismutase (SOD) as indicators of oxidative stress in mice was also investigated. There was significant (p < 0.05) inhibition of root growth and mitosis in A. cepa. Cytological aberrations such as spindle disturbance, C-mitosis and binucleated cells, and morphological alterations like tumor and twisting roots were also induced. There was concentration-dependent, significant (p < 0.05) induction of micronucleated erythrocytes and nuclear abnormalities such as blebbed nuclei and binucleated erythrocytes in C. gariepinus. A significant increase (p < 0.001) in CAT, GSH and MDA with concomitant decrease in SOD concentrations were observed in the treated mice. Pb, As, Cu, Cr, and Cd analyzed in the tested samples contributed significantly to these observations. This shows that the well water samples and leachate contained substances capable of inducing somatic OPEN ACCESSChallenges 2013, 4 170 mutation and oxidative stress in living cells; and this is of health importance in countries with risk of e-wastes exposure.

show abstract

Section: Discussionsupporting

confidence: 88%

“…The heavy metals and organic compounds present in the well water samples and e-waste leachate [10] are known to generate ROS that caused DNA, protein and lipid damage in eukaryotic cells [57]. These chemicals mostly heavy metals can bind to phosphate and base residues of DNA, to alter its primary and secondary structures [68].…”

Section: Discussionmentioning

confidence: 99%

In Vivo Cytogenotoxicity and Oxidative Stress Induced by Electronic Waste Leachate and Contaminated Well Water

et al. 2013

View full text Add to dashboard Cite

show abstract

“…These free radicals could attack nucleic acids, result in base substitution and breakage of DNA, and eventually induce mutation . In this regard, it would be noteworthy to state that Cd, Cu, and Fe (Cd and Fe were found at high concentrations in the test leachates) have been reported to induce reactive oxygen species in eukaryotic systems [Ghio et al, 2002;Radetski et al, 2004].…”

Section: Discussionmentioning

confidence: 94%

DNA damage induced in human peripheral blood lymphocytes by industrial solid waste and municipal sludge leachates

Bakare

Pandey

Bajpayee

et al. 2006

Environ and Mol Mutagen

View full text Add to dashboard Cite

Exposure of humans to toxic compounds occurs mostly in the form of complex mixtures. Leachates, consisting of mixtures of many chemicals, are a potential risk to human health. In the present study, leachates of solid wastes from a polyfiber factory (PFL), an aeronautical plant (AEL), and a municipal sludge leachate (MSL) were assessed for their ability to induce DNA damage in human peripheral blood lymphocytes using the alkaline Comet assay. The leachates also were examined for their physical and chemical properties. Lymphocytes were incubated with 0.5-15.0% concentrations (pH range 7.1-7.4) of the test leachates for 3 hr at 37 degrees C, and treatment with 1 mM ethyl methanesulfonate served as a positive control. All three leachates induced significant (P < 0.05), concentration-dependent increases in DNA damage compared with the negative control, as measured by increases in Olive tail moment (arbitrary units), tail DNA (%), and tail length (mum). A comparison of these variables among the treatment groups indicated that the MSL induced the most DNA damage. Inductively coupled plasma emission spectrometry analysis of the leachates indicated that they contained high concentrations of heavy metals, viz. iron, manganese, nickel, zinc, cadmium, chromium, and lead. The individual, synergistic, or antagonistic effects of these chemicals in the leachates may be responsible for the DNA damage. Our data indicate that the ever-increasing amounts of leachates from waste landfill sites have the potential to induce DNA damage and suggest that the exposure of human populations to these leachates may lead to adverse health effects.

show abstract

“…In plants, some metal compounds are known to be responsible for genotoxic effects (Radetski et al 2004). The involved mechanism is unclear.…”

Section: Introductionmentioning

confidence: 99%

“…The involved mechanism is unclear. In plants, there are insufficient data about the possible involvement of a putative reactive oxygen species (ROS)-mediated mechanism in the genotoxicity of metals (Radetski et al 2004;Kasai et al 1992). Cd 2+ induces genotoxicity and programmed cell death (Behboodi and Samadi 2004;Garnier et al 2006;Ünyayar et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Micronucleus frequency and lipid peroxidation in Allium sativum root tip cells treated with gibberellic acid and cadmium

et al. 2007

View full text Add to dashboard Cite

Gibberellic acid (GA(3)) is a very potent hormone whose natural occurrence in plants controls their development. Cadmium is a particularly dangerous pollutant due to its high toxicity and great solubility in water. In this study, the effect of GA(3) on Allium sativum root tip cells was investigated in the presence of cadmium. A. sativum root tip cells were exposed to CdNO(3) (50, 100, 200 microM), GA(3) (10-3 M), both CdNO(3) and GA(3). Cytogenetic analyses were performed as micronucleus (MN) assay and mitotic index (MI). Lipid peroxidation analysis was also performed in A. sativum root tip cells for determination of membrane damage. MN exhibited a dose-dependent increase in Cd treatments in A. sativum. GA(3) significantly reduced the effect of Cd on the MN frequency. MN was observed in GA(3) and GA(3) + 50 mum Cd treatments at very low frequency. MI slightly decreased in GA(3) and GA(3) + Cd treatments. MI decreased more in high concentrations of Cd than combined GA(3) + Cd treatments. The high concentrations of cadmium induce MN, lipid peroxidation and lead to genotoxicity in A. sativum. Current work reveals that the effect of Cd on genotoxicity can be partially restored with GA(3) application.

show abstract

Evaluation of the genotoxic, mutagenic and oxidant stress potentials of municipal solid waste incinerator bottom ash leachates

Cited by 62 publications

References 33 publications

In Vivo Cytogenotoxicity and Oxidative Stress Induced by Electronic Waste Leachate and Contaminated Well Water

In Vivo Cytogenotoxicity and Oxidative Stress Induced by Electronic Waste Leachate and Contaminated Well Water

DNA damage induced in human peripheral blood lymphocytes by industrial solid waste and municipal sludge leachates

Micronucleus frequency and lipid peroxidation in Allium sativum root tip cells treated with gibberellic acid and cadmium

Contact Info

Product

Resources

About