Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography

Kanamori, Akira; Nakamura, Makoto; Escaño, M.F.; Seya, Ryu; Maeda, Hidetaka; Negi, Akira

doi:10.1016/s0002-9394(02)02003-2

Cited by 321 publications

(222 citation statements)

References 28 publications

Supporting

Mentioning

187

Contrasting

Unclassified

Order By: Relevance

“…[9][10][11][12][13]19,20 Recently, we and Monteiro et al also reported that OCT could detect RNFL thickness reduction corresponding to band atrophy in eyes with compressive lesions at the chiasmal region. 14,21 In this study, peripapillary RNFL thickness of optic atrophy showed global reduction in all quadrantic sections consistent with previous reports on compressive optic neuropathy and traumatic optic neuropathy.…”

Section: Discussionmentioning

confidence: 73%

“…Macular thickness and RNFL thickness around the optic disc were measured by OCT (OCT1, Zeiss-Humphrey, Dublin, California), as reported previously. 13,22 In brief, retinal thickness was calculated using OCT retinal mapping software (version 6.1a), which measured thickness of nine divided macular regions (A0-A8) after six scans with 6 mm long under pupillary dilation and expressed as a colour-coded map. RNFL thickness was measured by 3.4-mm-diameter circle scans centred on the optic disc.…”

Section: Methodsmentioning

confidence: 99%

“…3,4 OCT has been mainly used for evaluating various types of retinal diseases, glaucoma, and optic nerve diseases. [5][6][7][8][9][10][11][12][13][14] In eyes with macular disease such as occult macular dystrophy, and various types of macular oedema, foveal thickness have shown a correlation with visual acuity, and alterations of macular thickness have been adopted in assessing progress of disease. [15][16][17][18] On the other hand, some studies remarked and demonstrated the decrease in peripapillary RNFL thickness in eyes with glaucoma, traumatic optic neuropathy, and compression optic neuropathy using OCT. [9][10][11][12][13][14]19,20 Although it has been reported that peripapillary RNFL thickness represents the severity of visual field loss and would be of clinical use, 14,21 little attention have been paid to the relationship between visual function and macular thickness in eyes with optic nerve disease.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

Kusuhara

Nakamura

Nagai-Kusuhara

et al. 2005

Eye

View full text Add to dashboard Cite

Aims To assess the changes in macular and peripapillary retinal nerve fibre layer (RNFL) thickness in eyes with unilateral optic atrophy and to evaluate the relationship between retinal thickness and visual function. Methods Enrolled were 22 patients with unilateral optic atrophy. Macular thickness at the divided nine areas and peripapillary RNFL thickness in quadrantic sections were measured by optical coherence tomography. Thickness values in the affected eyes were compared with those in the contralateral unaffected eyes. The correlation of foveal thickness with best-corrected visual acuity (BCVA) was evaluated. The correlation between retinal thickness and the remaining visual field area circumscribed with I-4-e isopter in superior and inferior hemifield was assessed.Results Macular thinning was observed in all areas (Po0.001 in each area) other than the fovea (P ¼ 0.068). Peripapillary RNFL thickness decreased in all quadrantic sections (Po0.001 in each section). The affected to unaffected eye ratio of retinal thickness was more than 0.6 in each area. BCVA did not correlate with foveal thickness (correlation coefficient ¼ 0.094, P ¼ 0.668). Although not statistically significant (P ¼ 0.281, superior hemifield; P ¼ 0.053, inferior hemifield), there was a tendency that eyes with severe visual field loss show more marked retinal thinning. Conclusions Macular thinning with the preserved foveal thickness is a hallmark of eyes with optic atrophy. Together with no correlation between foveal thickness and BCVA, this finding would help in differential diagnosis of macular and optic nerve diseases.

show abstract

Section: Discussionmentioning

confidence: 73%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

Kusuhara

Nakamura

Nagai-Kusuhara

et al. 2005

Eye

View full text Add to dashboard Cite

show abstract

“…Higher correlations were also observed in NFI/average thickness OCT and superior average in earlier studies. 18,22 NFI is a special retardation parameter in GDx-VCC that indicates the likelihood that glaucoma is present. It has a close relationship with RNFL thickness and VF status in glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Relationship between GDx VCC and Stratus OCT in juvenile glaucoma

Zareii

Soleimani

Moghimi

et al. 2009

Eye

View full text Add to dashboard Cite

Purpose To compare the ability of scanning laser polarimetry (GDx VCC) and optical coherence tomography (OCT) to discriminate eyes with juvenile glaucoma from normal eyes and to assess the relationship between their parameters. Methods A total of 24 glaucomatous eyes of 24 patients and 24 normal eyes were enrolled. The age range of the patient was 11-40 years with a mean age of 25.1 ± 8.2 years. Contol groups consisted 24 eyes of 24 individuals without glaucoma with a mean age of 33.2 ± 8.2 years. All subjects underwent a full ophthalmic examination, automated perimetry, GDx VCC, and OCT. Correlation coefficients between the parameters of OCT and GDx VCC were calculated. We calculated the area under the receiver operating characteristic curve (AROC) for the main parameters of GDx VCC and OCT.

show abstract

“…15,18,19 One of the most significant improvements of the OCT-3 version is its shorter acquisition time, especially in the FAST version used in the present study. In the OCT-1 version, images are produced from 100 A-scans performed during 1 s. 6,20 On the other hand, when using the FAST protocol with OCT-3, images are produced from 256 A-scans performed during a four-times shorter acquisition time. 15 Thus, three images are captured from which the software automatically calculates the mean.…”

Section: Discussionmentioning

confidence: 99%

Comparison of retinal nerve fibre layer measurements using optical coherence tomography versions 1 and 3 in eyes with band atrophy of the optic nerve and normal controls

Monteiro

Leal

Moura

et al. 2005

Eye

View full text Add to dashboard Cite

Aims To compare retinal nerve fibre layer (RNFL) measurements were carried out with two different versions of an optical coherence tomography device in patients with band atrophy (BA) of the optic nerve and in normal controls. Methods The RNFL of 36 eyes (18 with BA and 18 normals) was measured using an earlier version of an optical coherence tomography device (OCT-1). The measurements were repeated using a later version of the same equipment (OCT-3), and the two sets of measurements were compared. Results Using OCT-1, the peripapillary RNFL thickness (mean7SD, in lm) in eyes with BA measured 80.4276.94, 99.81714.00, 61.69713.02, 101.70712.54, and 57.36716.52 corresponding to the total RNFL average, superior, temporal, inferior, and nasal quadrants, respectively. Using OCT-3, the corresponding measurements were 63.1176.76, 81.22713.34, 39.5078.27, 86.72715.16, and 45.0578.03. Each of these measurements was significantly smaller with OCT-3 than with OCT-1. In normal eyes, RNFL average and temporal quadrant OCT-3 values were significantly smaller than OCT-1 values, but there was no significant difference in measurements from the superior, inferior, and nasal quadrant.Conclusions RNFL measurements were smaller with OCT-3 than with OCT-1 for almost all parameters in eyes with BA and in the global average and temporal quadrant measurements in normal eyes. Investigators should be aware of this fact when comparing old RNFL measurement with values obtained with later versions of the equipment.

show abstract

Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography

Cited by 321 publications

References 28 publications

Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

Relationship between GDx VCC and Stratus OCT in juvenile glaucoma

Comparison of retinal nerve fibre layer measurements using optical coherence tomography versions 1 and 3 in eyes with band atrophy of the optic nerve and normal controls

Contact Info

Product

Resources

About