Evaluation of the glioblastoma multiforme treatment with hyperthermia using the finite element method

Sağıroğlu, Ayşe; Karagöz, İlke; Özcan, Öznur Özge; Ergüzel, Türker Tekin; Karahan, Mesut; Tarhan, Nevzat

doi:10.1080/10407782.2022.2102404

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…The FVM is one of the most popular numerical simulation methods. − Its basic idea is as follows: The calculation area is first divided into a series of unrepeated grids and elements, and the control area is circled at each grid point. Then, the differential equation is integrated in each control area, and the integral is discretized.…”

Section: Mathematical Modelmentioning

confidence: 99%

Gas Dispersion Coefficient Test System and Dimensionless Inversion Method for Porous Media

Qin,

Guo,

Zhang

et al. 2023

ACS Omega

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Due to the complex porous media structure of the longwall gob area, it has been difficult to determine the gas dispersion coefficient of oxygen when studying spontaneous coal combustion in the gob area. In this work, we first designed an experimental device for testing the gas diffusion coefficient of porous media. Then, the distribution law of gas concentration in porous media under different particle size conditions was obtained by experiments. Subsequently, we established a dimensionless mathematical model of gas dispersion in porous media and developed a corresponding numerical simulator based on the finite volume method (FVM). The influence of the dimensionless gas dispersion coefficient on the gas concentration distribution was analyzed, and then a dimensionless inversion method of the gas dispersion coefficient was summarized and put forward. Finally, we obtained the values of the gas dispersion coefficient in the experimental device under different particle size conditions by inversion and discussed its effect on the gas dispersion behavior in porous media. The results show that (1) the distribution of gas concentration obtained from the experimental test and numerical simulation is consistent, which verifies the reliability of our work; (2) the dimensionless gas concentration is the highest near the injection point and gradually decreases along the depth and both sides of the test container; (3) with the increase of the dimensionless gas dispersion coefficient, the distance required for uniform gas mixing in the test container is gradually shortened and the gas dispersion coverage is wider; and (4) the larger pore space facilitates the dispersion behavior of the gas, and the gas dispersion coefficient shows a parabolic trend with the increase of porous medium particle size.

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Section: Mathematical Modelmentioning

confidence: 99%

Gas Dispersion Coefficient Test System and Dimensionless Inversion Method for Porous Media

Qin,

Guo,

Zhang

et al. 2023

ACS Omega

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“…Safe parameters for power, frequency, time interval, and antenna catheter properties were determined for the treatment of GBM in the brain. The application duration was approximately 10 min, power ranged from 5 to 10 W, frequency varied between 0.915 GHz and 2.45 GHz, and the antenna geometry required a length of 70 mm and a width of 30 mm to suit the tissue [81].…”

Section: Hyperthermia and Phototherapymentioning

confidence: 99%

Recent advancements and theranostics strategies in glioblastoma therapy

Baddam,

Kalagara,

Kuna

et al. 2023

Biomed. Mater.

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Glioblastoma (GBM) is the most aggressive and lethal malignant brain tumour, and it is challenging to cure with surgery and treatment. The prevention of permanent brain damage and tumour invasion, which is the ultimate cause of recurrence, are major obstacles in GBM treatment. Besides, emerging treatment modalities and newer genetic findings are helping to understand and manage GBM in patients. Accordingly, researchers are focusing on advanced nanomaterials-based strategies for tackling the various problems associated with GBM. In this context, researchers explored novel strategies with various alternative treatment approaches such as early detection techniques and theranostics approaches. In this review, we have emphasized the recent advancement of GBM cellular models and their roles in designing GBM therapeutics. We have added a special emphasis on the novel genetic and drug target findings as well as strategies for early detection. Besides, we have discussed various theranostic approaches such as hyperthermia therapy, phototherapy and image-guided therapy. Approaches utilized for targeted drug delivery to the GBM were also discussed. This article also describes the recent in vivo, in vitro and ex vivo advances using innovative theranostic approaches.

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Evaluation of the glioblastoma multiforme treatment with hyperthermia using the finite element method

Cited by 2 publications

References 15 publications

Gas Dispersion Coefficient Test System and Dimensionless Inversion Method for Porous Media

Gas Dispersion Coefficient Test System and Dimensionless Inversion Method for Porous Media

Recent advancements and theranostics strategies in glioblastoma therapy

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