Evaluation of the Grafted Fascia in the Vocal Fold of Dogs: A Histologic Study

Carvalho, Eduardo George Batista de; Pauna, Henrique Furlan; Júnior, Almiro José Machado; Nicola, Ester Maria Danielli; Altemani, Albina; Crespo, Agrício Nubiato

doi:10.1016/j.jvoice.2016.12.022

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…Autologous fascial graft, according to Carvalho et al seems not to cause inflammatory reaction response in the histologic evaluation on grafted fascia in vocal fold of dog harvested two months from its implantation [12].…”

Section: Discussionmentioning

confidence: 98%

Autologous fascial slings remain viable at long-term follow-up: a post cystectomy case report

et al. 2021

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Background Autologous fascial slings (AFS) have been used for a very long time in the treatment of female stress urinary incontinence, but the introduction of synthetic mesh slings placed either retropubicallyor trans-obturator has decreased the need to harvest the autologous rectus muscle fascia, thus reducing invasiveness and operative time. However AFS are still indicated in complicated cases and re-interventions, and the FDA has underlined safety concerns over the use of surgical meshes for the transvaginal repair of prolapsed pelvic organs. Case presentation A 76-year-old woman with muscle-invasivebladder cancer underwent radical cystectomy 16 years after retropubic positioning of an autologous rectus muscle fascial sling for SUI, with complete symptom resolution. The sling was easily identified and removed en bloc with the bladder and urethra, providing an opportunity to histologicallyevaluate the autologous fascial graft after its long permanence in the new position. Histopathological examination demonstrated increased fibroblastic proliferation and formation of capillaries. A slight separation and an increased waviness of the connective fibers were both evident. An increased vascularity was also apparent, including transverse vessels, with clusters of vessels. A relative inflammatory reaction was present in over 300 cells/10 HPF. All these characteristics indicated viable connective tissue. Conclusions AFS remain a valuable surgical option for both primary and recurrent SUI in women, showing high cure rates and low complications in the long-term. The present case, to the best of our knowledge, presents the longest follow-up period of an autologous rectus muscle fascia placed retropubically and its histological evaluation documents characteristics which support its mechanical strength and viability.

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Section: Discussionmentioning

confidence: 98%

Autologous fascial slings remain viable at long-term follow-up: a post cystectomy case report

et al. 2021

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“…The extracellular matrix of the lamina propria is rich in type-III collagen, elastin, hyaluronic acid, fibronectin, and fibroblasts [1,2]. The ultrastructure of the lamina propria and the basal membrane region contains sparse cellular material interposed to an extracellular matrix (allegedly responsible for the vocal fold's vibratory feature) [1, 3,4]. The basal membrane visualized in electron microscopy studies was divided into lamina lucida (electron-lucent), lamina densa (electrondense), and lamina fibro-reticularis (electronlucent) [1,3].…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Analysis of Laryngeal Lesions and Clinical-Laryngoscopic Correlation

Rimoli¹,

Hamerschmidt²,

Dutra³

et al. 2022

Arch Otolaryngol Head Neck Surg

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Introduction: The vocal fold is vulnerable to several types of lesions. Immunohistochemistry is a technique aimed to complement the routine histopathological investigation, showing the presence of different antigens in the tissue or cell by means of specific antibodies, thus allowing the assessment of the potential proliferation of neoplastic cells. Objective: Detailed review of the results of vocal fold biopsies and correlation between histopathological data and clinical course among patients. Methods: A descriptive retrospective study based on the analysis of medical records of patients undergoing laryngeal microsurgery due to benign diseases (polyps and nodules), whose biopsies required additional investigation using immunohistochemistry techniques. All biopsies were carried out by the same specialist, from January 2018 to December 2019 at the Hospital Paranaense de Otorrinolaringologia. Results: Seven out of the 29 patients included in this study (26 male and 3 female patients) claimed to be tobacco users. All the 18 patients investigated for high-risk HPV scored negative in diagnostic immunohistochemistry. Three of the 19 patients with suspected laryngeal papillomatosis resulted in squamous cell carcinoma in the anatomopathological examination. Conclusion: Due to similar histopathological aspects between the different types of vocal fold lesions, there is considerable doubt regarding the gold standard in histopathological examination. To determine the difference between benign lesions of the larynx, this paper reinforce the major role of performing immunohistochemistry examinations in the diagnosis of apparently benign lesions regarding early diagnosis and treatment.

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Evaluation of the Grafted Fascia in the Vocal Fold of Dogs: A Histologic Study

Cited by 2 publications

References 28 publications

Autologous fascial slings remain viable at long-term follow-up: a post cystectomy case report

Autologous fascial slings remain viable at long-term follow-up: a post cystectomy case report

Immunohistochemical Analysis of Laryngeal Lesions and Clinical-Laryngoscopic Correlation

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