Evaluation of the Granulation of a Hydrophilic Matrix Sustained Release Tablet

Abstract

W e t g r a n u l a t i o n of a hydrophilic s u s t a i n e d release matrix t a b l e t formulation has been s t u d i e d .

Formulation and release kinetics of ibuprofen–bentonite tablets

“…Similarly, Alkrad et al (2017) used a 50% mixture of bentonite with different drugs to study the release behavior from prepared tablets by direct compression (Alkrad et al, 2017). The produced blends had poor flowability, which was considered the main limitation of the direct compression method (Aulton & Taylor, 2013;Franc et al, 2018;Timmins et al, 1991). Hence, the current investigation was designed to granulate bentonite before compression to improve flowability and enable large-scale production of IBbentonite tablets.…”