Evaluation of the Hemodynamic Effects of AC Magnetic Field Exposure by Measurement of an FMD and a Microscope

Kondo, Tsukasa; Okano, Hideyuki; Ishiwatari, Hiromi; Watanuki, Keiichi

doi:10.1007/978-3-319-94373-2_8

Cited by 5 publications

(11 citation statements)

References 31 publications

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“…In addition, from the results of FMD test, the MF exposure significantly increased FMD values compared to the baseline value as well as compared to the sham exposure. The results were consistent with our previous findings investigated with smaller sample sizes [ 51 ]. As FMD is an indicator of vascular endothelial function and shear stress-induced nitric oxide (NO) production [ 62 – 64 ], the MF-induced increase of FMD values is largely related to enhancement of NO production [ 51 ].…”

Section: Discussionsupporting

confidence: 94%

“…Therefore, MF-induced increase in FMD values largely indicates enhancement of NO production and NO-mediated vasodilator response. The FMD values were evaluated before (baseline) and after 30-min exposure to MFs as described previously [ 51 ]. The CV values for the baseline FMD values in the same individual were within 30% across the four testing session: 15.1% ± 9.1% (mean ± SD), range 4.1–29.9%, n = 16.…”

Section: Resultsmentioning

confidence: 99%

“…We conducted the preliminary trial protocol of FMD measurement of the left brachial artery under the left upper arm exposure to a 50 Hz MF and the protocol was described previously [ 51 ]. FMD measurement was performed as shown in Fig D in S4 File .…”

Section: Methodsmentioning

confidence: 99%

“…Randomization was performed according to our preliminary trial protocol [ 50 , 51 ]. Briefly, all participants were divided evenly into two conditions, a real MF (A) and a sham (B) exposures, with an allocation ratio of 1:1 after block randomization with a permuted block size of 2 according to computer-generated random numbers by an administrative controller/investigator (H.O.)…”

Section: Methodsmentioning

confidence: 99%

“…Many experimental and epidemiological studies for exploring biological and health effects on extremely low-frequency magnetic fields (ELF-MFs) ranging 1–300 Hz have been carried out and reviewed [ 1 – 51 ]. Aside from potential health concerns, medical applications of ELF-MFs are promising research areas to be explored using a ubiquitous sinusoidal frequency.…”

Section: Introductionmentioning

confidence: 99%

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A 50 Hz magnetic field affects hemodynamics, ECG and vascular endothelial function in healthy adults: A pilot randomized controlled trial

et al. 2021

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Application of exposure to 50/60 Hz magnetic fields (MFs) has been conducted in the treatment of muscle pain and fatigue mainly in Japan. However, whether MFs could increase blood flow leading to muscle fatigue recovery has not been sufficiently tested. We investigated the acute effects of a 50 Hz sinusoidal MF at Bmax 180 mT on hemodynamics, electrocardiogram, and vascular endothelial function in healthy young men. Three types of regional exposures to a 50 Hz MF, i.e., forearm, upper arm, or neck exposure to MF were performed. Participants who received three types of real MF exposures had significantly increased ulnar arterial blood flow velocity compared to the sham exposures. Furthermore, after muscle loading exercise, MF exposure recovered hemoglobin oxygenation index values faster and higher than sham exposure from the loading condition. Moreover, participants who received real MF exposure in the neck region had significantly increased parasympathetic high-frequency activity relative to the sham exposure. The MF exposure in the upper arm region significantly increased the brachial artery flow-mediated dilation compared to the sham exposure. Computer simulations of induced in situ electric fields indicated that the order-of-magnitude estimates of the peak values were 100–500 mV/m, depending on the exposure conditions. This study provides the first evidence that a 50 Hz MF can activate parasympathetic activity and thereby lead to increase vasodilation and blood flow via a nitric oxide-dependent mechanism. Trial registration: UMIN Clinical Trial Registry (CTR) UMIN000038834. The authors confirm that all ongoing and related trials for this drug/intervention are registered.

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Section: Discussionsupporting

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A 50 Hz magnetic field affects hemodynamics, ECG and vascular endothelial function in healthy adults: A pilot randomized controlled trial

et al. 2021

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Goshajinkigan increases peripheral capillary diameter in non‐diabetic and diabetic mice

Inagaki

Furuta

Asada

et al. 2020

Traditional & Kampo Medicine

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Aim Goshajinkigan (GJG) improves hyperesthesia and hypoesthesia in diabetic peripheral neuropathy (DPN) by increasing nitric oxide (NO) production. In this study, we investigated the involvement of NO in the vasodilatory effect of GJG in peripheral capillaries to clarify the mechanism related to DPN symptom improvement. Methods GJG was orally administered to non‐diabetic and streptozotocin (STZ)‐induced diabetic male mice. Auricular venule and arteriole diameters were measured by video capillaroscopy. The mice were pretreated with NG‐nitro‐L‐arginine methyl ester (L‐NAME) to assess NO involvement. Results GJG increased venule and arteriole diameters in both non‐diabetic and diabetic mice. L‐NAME pretreatment inhibited GJG‐induced increases in capillary diameter. Conclusion The direct vasodilatory effect of GJG in peripheral arterioles and venules involved increased NO production.

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Production and characterization of magnetic textiles

Başyiğit

Beden²,

Coşkun³

2022

The Journal of The Textile Institute

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Evaluation of the Hemodynamic Effects of AC Magnetic Field Exposure by Measurement of an FMD and a Microscope

Cited by 5 publications

References 31 publications

A 50 Hz magnetic field affects hemodynamics, ECG and vascular endothelial function in healthy adults: A pilot randomized controlled trial

A 50 Hz magnetic field affects hemodynamics, ECG and vascular endothelial function in healthy adults: A pilot randomized controlled trial

Goshajinkigan increases peripheral capillary diameter in non‐diabetic and diabetic mice

Production and characterization of magnetic textiles

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