Evaluation of the Hepatic and Renal-protective Effects of Ganoderma lucidum in Mice

Abstract

The antioxidative effect of hot water extract of the mushroom Ganoderma lucidum on ethanol-induced free radical generation had been studied. In order to further investigate the hepatic and renal protective mechanism of Ganoderma lucidum, rates of lipid peroxidation were determined. The hot water extract of Ganoderma lucidum dose-dependently exhibited antioxidative effect on mouse liver and kidney lipid peroxidation; our results indicated that hepatic and renal homogenates have a higher malonic dialdehyde level in an ethanol administered group than in the Ganoderma lucidum treated group. It was concluded that the hepatic and renal protective mechanism of Ganoderma lucidum, might be due at least in part to its prominent superoxide scavenging effect. Ganoderma extract could protect the liver and kidney from superoxide induced hepatic and renal damages.

Hepatoprotective Effects of Mushrooms

“…The effects of total triterpenoids extracts from G. lucidum on two different experimental liver injury models induced by carbon tetrachloride and D-galactosamine were extensively studied in mice [35,40,108,109]. Administration of the extract (80 mg/kg) significantly inhibited the increase of serum ALT and liver triglyceride levels in the models, effects similar to those of malotilate, a known reference substance for this kind of protective effects [110].…”

“…Nevertheless, chemical toxins (including acetaminophen, carbon tetrachloride, thioacetamide, ethanol, D-galactosamine, diethylnitrosamine and dimethylnitrosamine) are often used as the model substances causing experimental hepatocyte injury under both in vivo and in vitro conditions [10,[34][35][36][37][38][39][40][41][42][43][44][45][46][47].…”

“…[ 35,38,[98][99][100][101] Ganoderma tsugae CCl 4 Extracts present anti-fibrotic actions and diminish the levels of ALT and AST; the extract significantly decreases the prothrombine time.…”

Cordyceps Mushroom: A Potent Anticancer Nutraceutical

“…Ganoderma lucidum has been proved to have anti microbial and anti-HIV effects [7,8]. The hepatic and renal protective effects of G. lucidum in mice were also evaluated [9]. The beta-glucan polysaccharide of this mushroom has potential application in immune surveillance and chemoprevention of cancer [2].…”

NMR metabolic profiling of the liver following administrationof alcohol andthemushroom Ganoderma lucidum in rats

“…Тритерпеноиды обладают антиок-сидантной активностью и способны связывать свободные радикалы (�ang et al, 2000;Shi et al, 2008), а полисаха-риды эффективно ингибируют развитие окислительного стресса в мозге при гипоксии и реоксигенации (�hao et al, 2004). Терапевтическая эффективность Рейши была также продемонстрирована на моделях гепатостеатоза (Shieh et al, 2001) и экспериментально индуцированного фиброза печени (�u et al, 2010).…”