Evaluation of the high affinity [18F]fluoropyridine-candesartan in rats for PET imaging of renal AT1 receptors

Diaz, Aida M. Abreu; Drumeva, Gergana O.; Laporte, Philippe; Martínez, Luis; Petrenyov, D. R.; Carrier, Jean‐François; DaSilva, Jean N.

doi:10.1016/j.nucmedbio.2021.03.003

Nuclear Medicine and Biology

2021

DOI: 10.1016/j.nucmedbio.2021.03.003

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Evaluation of the high affinity [18F]fluoropyridine-candesartan in rats for PET imaging of renal AT1 receptors

Aida M. Abreu Diaz

Gergana O. Drumeva

Philippe Laporte

et al.

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2024

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Medicinal (Radio) Chemistry: Building Radiopharmaceuticals for the Future

Pijeira,

Nunes,

Chaviano

et al. 2024

CMC

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Radiopharmaceuticals are increasingly playing a leading role in diagnosing, monitoring, and treating disease. In comparison with conventional pharmaceuticals, the development of radiopharmaceuticals does follow the principles of medicinal chemistry in the context of imaging-altered physiological processes. The design of a novel radiopharmaceutical has several steps similar to conventional drug discovery and some particularity. In the present work, we revisited the insights of medicinal chemistry in the current radiopharmaceutical development giving examples in oncology, neurology, and cardiology. In this regard, we overviewed the literature on radiopharmaceutical development to study overexpressed targets such as prostate-specific membrane antigen and fibroblast activation protein in cancer; β-amyloid plaques and tau protein in brain disorders; and angiotensin II type 1 receptor in cardiac disease. The work addresses concepts in the field of radiopharmacy with a special focus on the potential use of radiopharmaceuticals for nuclear imaging and theranostics.

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Medicinal (Radio) Chemistry: Building Radiopharmaceuticals for the Future

Pijeira,

Nunes,

Chaviano

et al. 2024

CMC

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show abstract

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Evaluation of the high affinity [18F]fluoropyridine-candesartan in rats for PET imaging of renal AT1 receptors

Cited by 1 publication

References 46 publications

Medicinal (Radio) Chemistry: Building Radiopharmaceuticals for the Future

Medicinal (Radio) Chemistry: Building Radiopharmaceuticals for the Future

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