2024
DOI: 10.3390/cancers16010209
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Evaluation of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer

Christos Damaskos,
Iason Psilopatis,
Anna Garmpi
et al.

Abstract: Background/Aim: Triple negative breast cancer belongs to the most aggressive breast cancer forms. Histone deacetylases (HDACs) constitute a class of enzymes that exhibit a significant role in breast cancer genesis and progression. In this study, we aimed at assessing the clinical importance of HDAC-2 in triple negative breast cancer. Materials and Methods: A total of 138 breast cancer specimens were examined on an immunohistochemical basis. A statistical analysis was performed in order to examine the associati… Show more

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“…This process leads to histone deacetylation via a charge relay mechanism [ 13 ]. HDAC1, HDAC2, and HDAC3 exhibit not just nuclear localization but also wide expression, implying a potentially key involvement in carcinogenesis [ 14 , 15 , 16 ]. Inhibitors of HDAC were identified as an emerging category of chemotherapeutic agents.…”
Section: Introductionmentioning
confidence: 99%
“…This process leads to histone deacetylation via a charge relay mechanism [ 13 ]. HDAC1, HDAC2, and HDAC3 exhibit not just nuclear localization but also wide expression, implying a potentially key involvement in carcinogenesis [ 14 , 15 , 16 ]. Inhibitors of HDAC were identified as an emerging category of chemotherapeutic agents.…”
Section: Introductionmentioning
confidence: 99%