Evaluation of the HIV-1 reverse transcriptase inhibitory properties of extracts from some medicinal plants in Kenya

Kofi-Tsekpo, Mawuli W.; Kurokawa, Mineo; Kageyama, Seiji; Mungai, G.M.; Muli, John M; Tolo, Festus; Kibaya, Rukia; Muthaura, C.N.; Kanyara, J.N.; Tukei, P.M.; Shiraki, Kimíyasu

doi:10.4314/ajhs.v9i1.30758

Cited by 15 publications

(11 citation statements)

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“…People in sub-Saharan Africa, particularly the poor are still dependent on medicinal plants for the treatment of basic human ailments like backache, cold, cough, diarrhea, fever, headache, skin infections and wounds [14,17,24,44]. Therefore, traditional medicines remain the main source of primary health care available and accessible to all people in sub-Saharan Africa.…”

Section: Discussionmentioning

confidence: 99%

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Alternative Medicines for HIV/AIDS in Resource-Poor Settings: Insight from Traditional Medicines Use in Sub- Saharan Africa

Maroyi¹

2014

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

“…Tree Bark/fruits Herpes simplex (Namibia, Tanzania) [1,3,4], diarrhea (Namibia) [3], skin rash (Uganda) [12] Inhibits HIV-1 reverse transcriptase [24] Brassicaceae Raphanus sativus L. …”

Section: Shrub Leaves/roo Tsmentioning

confidence: 99%

Alternative Medicines for HIV/AIDS in Resource-Poor Settings: Insight from Traditional Medicines Use in Sub- Saharan Africa

Maroyi¹

2014

Trop. J. Pharm Res

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“…Natural products of plant origin have been found to contain antiviral properties worldwide [12,13,14,18]. Therefore there are possibilities of future antivirals being derived from plants or their constituents.…”

Section: Discussionmentioning

confidence: 99%

“…Natural products of plant origin are proving to be a valuable source for anti-viral agents [12,13,14]. We hereby report on extracts from three medicinal plants that grow in Kenya which have shown significant activity against HCMV in vitro.…”

Section: Introductionmentioning

confidence: 99%

In vitro anti-viral activity of aqueous extracts of Kenyan <i>Carissa edulis Prunus africana</i> and <i>Melia azedarach against human cytomegalovirus.</i>

Tolo¹,

Muli²,

Ochora³

et al. 2008

African Journal of Health Sciences

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“…Prunus Africana (Rosaceae) Anti-HIV-1 (Rukunga et al, 2002) antifungal, antibacterial (Bii et al, 2010) hypoglycemic activity . Has less acute toxic effect (Nabende 2015).…”

Section: Dovyalis Abyssinica (Flacourtiaceae)mentioning

confidence: 99%

Medicinal plants used in the management of diabetes by traditional healers of Narok County, Kenya

Kamau¹,

Mbaabu²,

Karuri³

et al. 2017

TANG [HUMANITAS MEDICINE]

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The Maasai community from Kenya is highly esteemed for their strong adherence to traditional cultures and ethno medicine. This is attributed to their age-old traditional mechanisms of passing down knowledge to the younger generation. Adoption to new socio-economic lifestyle and urbanization has been associated with development of diabetes, which has been reported among some indigenous pastoral communities in Kenya. Documentation of traditional methods of treatment and management of diabetes by the Maasai has not yet been reported, yet it is noteworthy. Thirty traditional healers from Narok County were purposively selected and interviewed about traditional knowledge of antidiabetic medicinal plants, parts used, preparation dosage and administration. A total of 14 antidiabetic plant species distributed within 13 genera and 12 families were identified and documented as herbal medicine used in the management of diabetes. The most highly cited plant species was Dovyalis abyssinica (20%), the plant family Flacourtiaceae and Rhamnaceae (2 plant species each) recorded the highest number of plant species while the most frequently used plant part was the roots (46%). Literature review revealed that some of the cited plants have known phytochemicals with antidiabetic activity; the study recommends further scientific investigation to validate their efficacy and safety.

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Evaluation of the HIV-1 reverse transcriptase inhibitory properties of extracts from some medicinal plants in Kenya

Cited by 15 publications

References 0 publications

Alternative Medicines for HIV/AIDS in Resource-Poor Settings: Insight from Traditional Medicines Use in Sub- Saharan Africa

Alternative Medicines for HIV/AIDS in Resource-Poor Settings: Insight from Traditional Medicines Use in Sub- Saharan Africa

In vitro anti-viral activity of aqueous extracts of Kenyan <i>Carissa edulis Prunus africana</i> and <i>Melia azedarach against human cytomegalovirus.</i>

Medicinal plants used in the management of diabetes by traditional healers of Narok County, Kenya

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