Evaluation of the human serum albumin column as a discovery screening tool for plasma protein binding

Plasma protein binding of polyphenols from maritime pine bark extract (USP)

“…This method requires a calibration using reference drugs with known protein binding values. The validity of obtained results is high when chemically similar molecules are used as reference and test compounds [27]. We therefore chose reference drugs with aromatic structure and an acidic functional group.…”

Location of High and Low Affinity Fatty Acid Binding Sites on Human Serum Albumin Revealed by NMR Drug-competition Analysis

“…[11][12][13][14][15] Binding of drugs to albumin alters the pattern and volume of distribution, lowers the rate of clearance, and increases the plasma half-life of the drug. [16][17][18][19] Although drugs can bind to other plasma proteins, albumin is the primary binding protein for lipophilic drugs with anionic or electronegative features.…”

Study on the competitive reaction between bovine serum albumin and neomycin with ponceau S as fluorescence probe

“…Albumin also binds a variety of drug molecules; a property that can have profound effects on their pharmacokinetics and pharmacodynamics has long been of interest to the pharmaceutical industry [3][4][5][6][7]. Binding to albumin controls the free, active concentration of a drug, provides a reservoir for a long duration of action, and ultimately affects drug absorption, metabolism, distribution and excretion.…”