Evaluation of the immunomodulatory effects of five herbal plants

Amirghofran, Zahra; Azadbakht, Mohammed; Karimi, Mojtaba

doi:10.1016/s0378-8741(00)00234-8

Cited by 138 publications

(89 citation statements)

References 9 publications

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“…In traditional medicine, D. kotschyi is used for stomach and liver disorders because of its antispasmodic and analgesic properties (Jahaniani et al 2005). It is also used for its antihyperlipidermic effects and immune modulatory effects (on rheumatoid arthritis) (Amirghofran et al 2000). This plant inhibits the multiplication of tumor cells; thus it has been used in the development of drugs effective against cancer (Cordell et al 1991).…”

Section: Introductionmentioning

confidence: 99%

Hairy root induction and plant regeneration of medicinal plant Dracocephalum kotschyi

Sharafi

Sohi

Azadi

et al. 2014

Physiol Mol Biol Plants

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An efficient hairy root induction system for an important endangered medicinal plant, Dracocephalum kotschyi, was developed through Agrobacterium rhizogenesmediated transformation by modifying the co-cultivation medium using five bacterial strains, A4, ATCC15834, LBA9402, MSU440, and A13 (MAFF-02-10266). A drastic increase in transformation frequency was observed when a Murashige and Skoog medium lacking NH 4 NO 3 KH 2 PO 4, KNO 3 and CaCl 2 was used, resulting in hairy root induction frequencies of 52.3 %, 69.6 %, 48.6 %, 89.0 %, and 80.0 % by A4, A13, LBA9402, MSU440, and ATCC15834 strains, respectively. For shoot induction, hairy roots and unorganized tumors induced by strain ATCC15834 were placed on an MS media supplemented with 0.1, 0.25, 0.5, and 1 mg/l BA plus 0.1 mg/l NAA. The high frequency of shoot regeneration and number of shoot were obtained in the medium containing 0.25 mg/l BA and 0.1 mg/l NAA. Root induction occurred from the base of regenerated shoots on the MS medium supplemented with 0.5 mg/l IBA after 10 days.

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Section: Introductionmentioning

confidence: 99%

Hairy root induction and plant regeneration of medicinal plant Dracocephalum kotschyi

Sharafi

Sohi

Azadi

et al. 2014

Physiol Mol Biol Plants

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“…Silymarin has also promotes hepatic tissue regeneration through increasing hepatocyte protein synthesis [33]. Recent studies showed that silybin can also slow or even reverse fibrosis [34,35] and has immunomodulatory effects on diseased liver [36,37].…”

Section: Resultsmentioning

confidence: 99%

Total Polyphenolic Content and Antioxidant Activity of Silybum Marianum Cultures Grown on Different Growth Regulators

Mekky

Sohafy

El-khair

et al. 2017

Int J Pharm Pharm Sci

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Objective: The present study was designed to study the effect of supplementing Silybum marianum cultures with different combinations and concentrations of growth regulators on the total phenolic content and the antioxidant activity of the produced cultures. Methods:The total polyphenolic content of 23 extracts of calli was calculated as µg of gallic acid/mg of dry weight extract (DWE) using FolinCiocalteu reagent. The antioxidant activity was calculated as trolox equivalent antioxidant capacity using 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) assay for extracts containing more than 10 µg gallic acid/mg DWE.Results: Most of the combinations showed an increase in the total polyphenolic concentration compared to the wild plant. However, cultures grown on media supplemented with combinations of benzyl aminopurine (BAP) and gebberellic acid (Gb), adenine (Ad) and kinetin (Kin), BAP and indole acetic acid (IAA) possessed the highest total polyphenolic contents 20.5, 13.09 and 12.15 µg gallic acid/mg DWE, respectively. However, only (BAP+Gb), (BAP+1-Naphthaleneacetic acid (NAA), IAA, kin and (BAP+Ad) showed a significant increase in the antioxidant activity calculated as trolox equivalent with 2.65, 1.56, 1.56, 1.35 and 1.22 folds increase over the wild plant, respectively. Conclusion:The results obtained clearly indicated that changing the growth regulator system of Silybum marianum cultures serves as an easy and reliable method for increasing the total phenolic content and the antioxidant activity of cultures.

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“…In the Flora of Syria, this genus is represented by 8 species [1]. Previous studies demonstrated therapeutic potentialities of Calendula officinalis L. such as anti-inflammatory activity [2][3][4][5], immunomodulatory [6][7], Hepatoprotective [8], wound-healing [9], antioxidant [10][11][12], antibacterial and antiparasitic activity [13][14][15][16]. The essential oil from C. officinalis has been also investigated [17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

A Novel Eudesmane Glycosides Sesquiterpene from <i>Calendula</i> <i>officinalis</i> L.

Sadaka¹

2016

IJPPE

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Abstract. The chromatographic separation of aqueous methanolic extract of Calendula officinalis led to the isolation of a new eudesmane sesquiterpene glycoside (1), together with tow known compounds, a lupane ester (2) and flavonoide gulcoside (3). Their structures were characterized to be 1β,3β,6α,8α,tetrahydroxyeudesm-4-ene 11-O-β-D-glucopyrnoside (1), 3β-E-caffoeyl lupeol (2), kaempferol-3-O-gulcoside (3) by spectroscopic means.

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Evaluation of the immunomodulatory effects of five herbal plants

Cited by 138 publications

References 9 publications

Hairy root induction and plant regeneration of medicinal plant Dracocephalum kotschyi

Hairy root induction and plant regeneration of medicinal plant Dracocephalum kotschyi

Total Polyphenolic Content and Antioxidant Activity of Silybum Marianum Cultures Grown on Different Growth Regulators

A Novel Eudesmane Glycosides Sesquiterpene from <i>Calendula</i> <i>officinalis</i> L.

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