Evaluation of the ImmuView RSV Test for Rapid Detection of Respiratory Syncytial Virus in Adult Patients with Influenza-Like Symptoms

Larsson, Eric; Johansson, Sofia; Fröbert, Ole; Nordenskjöld, Anna M.; Athlin, Simon

doi:10.1128/spectrum.00937-21

Cited by 6 publications

(4 citation statements)

References 23 publications

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“…While reverse transcription-polymerase chain reaction (RT-PCR) is the gold standard for RSV diagnosis, its widespread use in Latin America is hindered by its cost, limited availability, and need for specialized equipment and expertise [ 46 , 47 ]. Over recent years, rapid antigen detection test (RADT) options have been made available for RSV; although RADTs have modest sensitivity compared with RT-PCR, they are easy and quick to perform, making them valuable diagnostic tools (particularly in children) where access to RT-PCR may be limited [ 47 , 48 ]. Early use of RADTs is important, as prolonged symptoms are associated with false-negative test results [ 49 ]; however, the cost and necessity of RADTs should also be evaluated.…”

Section: Underdiagnosis Of Rsvmentioning

confidence: 99%

Understanding the Burden of Respiratory Syncytial Virus in Older Adults in Latin America: An Expert Perspective on Knowledge Gaps

Correa,

Arancibia,

De Ávila Kfouri

et al. 2024

Pulm Ther

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Respiratory syncytial virus (RSV) is a significant global health concern and major cause of hospitalization, particularly among infants and older adults. The clinical impact of RSV is well characterized in infants; however, in many countries, the burden and risk of RSV in older populations are overlooked. In Latin America, there are limited data on RSV epidemiology and disease management in older adults. Therefore, the impact of RSV in this region needs to be addressed. Here, current insights on RSV infections in older populations in Latin America, including those with underlying health conditions, are discussed. We also outline the key challenges limiting our understanding of the burden of RSV in Latin America in a worldwide context and propose an expert consensus to improve our understanding of the burden of RSV in the region. By so doing, we aim to ultimately improve disease management and outcomes of those at risk and to alleviate the impact on healthcare systems. A graphical plain language summary is available with this article. Graphical Plain Language Summary

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Section: Underdiagnosis Of Rsvmentioning

confidence: 99%

Understanding the Burden of Respiratory Syncytial Virus in Older Adults in Latin America: An Expert Perspective on Knowledge Gaps

Correa,

Arancibia,

De Ávila Kfouri

et al. 2024

Pulm Ther

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“…The most popular and accurate method to identify hMPV is reverse transcriptase PCR assays, which amplify the viral RNA. Targets commonly used include F, N, G, L, and M. The F and N genes are considered more specific and conserved for identifying hMPV [59,60].…”

Section: Diagnosis Of Hmpvmentioning

confidence: 99%

A Review on Human Metapneumovirus and Human Bocavirus Associated with Acute Respiratory Tract Infections

Narayanan

Nandagopal²,

Ramamurthy³

et al. 2023

AJRID

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One of the significant causes of morbidity and mortality among young children in developing nations is acute respiratory tract infections (ARTIs). It is also highly contagious, widely prevalent, and transmissible from person to person. It risks young children, the elderly, and those with immune system disorders. Acute respiratory infections are thought to cause 2.6 million child deaths annually worldwide, according to the World Health Organization (WHO) [1]. Infections in children with human metapneumovirus (hMPV) and bocavirus (HBoV) are linked to a high prevalence of ARTIs. It has been determined that hMPV is the second-leading cause of infant bronchiolitis, after the respiratory syncytial virus (RSV), of upper and lower respiratory tract infections. Although HBoV was first discovered in children's airways, the high detection rates of other viral pathogens and the discovery of HBoV in stool raise doubts about the virus's significance in respiratory tract infections. According to the published literature, only a few studies have identified ARTIs or demonstrated the importance of early diagnosis and treatment of ARTIs. This review article aims to thoroughly explain the aetiology, epidemiology, clinical characteristics, diagnostic approaches, and management of hMPV and HBoV.

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“…The study is limited by the lack of multicentre analysis, which makes these findings less generalisable, despite the relatively large number of patients included. Secondly, we did not perform molecular studies in each patient, and a classification into RSV versus non-RSV group based only on a negative rapid antigen test result is questionable; antigen tests are characterised by high specificity (above 90%) but lower sensitivity, reaching about 70%, although there are studies showing both much higher and much lower sensitivities (41)(42)(43)(44) . The lack of identification of other aetiological factors is, in our opinion, the most important shortcoming of the study, as it would not only reduce the risk of false negative RSV test results, but also the differentiation between certain agents (generally classified as non-RSV) may play a crucial role in the future.…”

Section: Multivariate Regression Modelmentioning

confidence: 99%

Clinical course and complications of RSV versus non-RSV bronchiolitis in hospitalised children

Kobiałka,

Jackowska,

Wrotek

2023

Pediatr Med Rodz

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Introduction and objective: Bronchiolitis in young children often requires hospitalisation. It is mostly caused by respiratory syncytial virus (RSV) and aetiological factors may be associated with clinical presentation and prognosis. We aimed to compare the epidemiology, clinical features, severity and management of RSV and non-RSV bronchiolitis. Materials and methods: This cross-sectional retrospective study included hospitalised children under 2 years of age. Children with a positive rapid antigen diagnostic test and/or molecular study were included in the RSV group, while those with a negative result were classified as non-RSV bronchiolitis. We compared patient history, clinical presentation, disease severity including passive oxygen therapy, intensive care unit transfer, death, length of hospital stay, presence of complications, oxygen saturation <92%, acidosis, hypercapnia and treatment used. Results: The study included 524 patients (median age 2 months): 462 (88%) RSV and 62 (12%) non-RSV cases. A 7-fold increase in the number of cases was observed between 2010–2011 and 2017–2018. A univariate regression model showed lower odds of family history of atopy (odds ratio, OR = 0.46), higher odds of cough (OR = 4.74), apathy (OR = 2.61), feeding difficulties (OR = 2.03) and vomiting (OR = 3.34) in the RSV group. RSV patients required oxygen therapy (OR = 3.78) and antibiotics (OR = 2.82) more frequently, received inhaled steroid therapy for longer (9 vs. 8 days) and had a higher likelihood of complications (OR = 4.24). A multivariate model showed statistical significance for cough (OR = 6.22), oxygen therapy (OR = 4.43) and complications (OR = 15.95). Conclusions: We observed an increasing trend in bronchiolitis hospitalisations, including RSV bronchiolitis, which was associated with a more severe disease course. No significant clinical features were identified to replace laboratory tests.

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Evaluation of the ImmuView RSV Test for Rapid Detection of Respiratory Syncytial Virus in Adult Patients with Influenza-Like Symptoms

Cited by 6 publications

References 23 publications

Understanding the Burden of Respiratory Syncytial Virus in Older Adults in Latin America: An Expert Perspective on Knowledge Gaps

Understanding the Burden of Respiratory Syncytial Virus in Older Adults in Latin America: An Expert Perspective on Knowledge Gaps

A Review on Human Metapneumovirus and Human Bocavirus Associated with Acute Respiratory Tract Infections

Clinical course and complications of RSV versus non-RSV bronchiolitis in hospitalised children

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