Evaluation of the impact of tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives on lepodova effects in the test of suspension by the tail

Abstract

A series of 1,3,5-thiadiazine derivatives exhibited high antidepressant and adaptogenical activity. We decided to unite two techniques for further research: evaluation of the impact of compounds with antidepressant activity on levodopa effects and the test of suspension by the tail. For comparison we chose: caffeine-sodium benzoate, amitriptyline and fluoxetine. Evaluation of the impact of 1,3,5thiadiazine derivatives on levodopa effects was chosen for more detailed analysis effects of studied substances on dopamine metabolism.