Changes in post-stroke physical condition have an impact on the emergence of psychological disorders in patients. Psychospiritual therapy helps patients with coping mechanisms against changes in health status experienced. This study aims to examine the pattern of transcultural-based psychospiritual therapy through the neurolinguistic programming (NLP) approach that can be used for post-stroke patients. This research is qualitative research with an ethnographic approach. The research was conducted on the Bugis community by involving stroke patients, patient's families, nurses, community leaders, and clergy. The study results show that post-stroke patients experience stress to depression related to changes in their physical condition. Psychospiritual treatment has been carried out in health facilities and community environments. The pattern of psychospiritual therapy based on transcultural nursing through the NLP approach can be made by (1) selecting the patient's habits, (2) giving positive suggestions about the patient's ability to get through all the trials that exist, and (3) giving the patient education and being involved in worship activities. Thus, psychospiritual therapy based on transcultural nursing with an NLP approach can be done by combining health facility services and local cultures that are not contradictory.